Results 51 to 60 of about 156,233 (327)
Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster [PDF]
, 2016 In vertebrates, TFEB (transcription factor EB) and MITF (microphthalmia-associated transcription factor) family of basic Helix-Loop-Helix (bHLH) transcription factors regulates both lysosomal function and organ development.
Busi, Ilaria +5 more
core +3 more sources
A thermo-physical analysis of the proton pump vacuolar-ATPase: the constructal approach [PDF]
, 2014 Pumping protons across a membrane was a critical step at the origin of life on earth, and it is still performed in all living organisms, including in human cells. Proton pumping is paramount to keep normal cells alive, e.g.
Deisboeck, Thomas S. +2 more
core +2 more sources
Rag GTPases are cardioprotective by regulating lysosomal function. [PDF]
, 2014 The Rag family proteins are Ras-like small GTPases that have a critical role in amino-acid-stimulated mTORC1 activation by recruiting mTORC1 to lysosome.
Guan, Kun-Liang +8 more
core +2 more sources
AMPK:Sensing Glucose as well as Cellular Energy Status [PDF]
, 2018 Mammalian AMPK is known to be activated by falling cellular energy status, signaled by rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs but also discuss new studies suggesting that AMPK is able to sense glucose ...
Hardie, David, Lin, Sheng-Cai
core +2 more sources
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification
Frontiers in Cell and Developmental Biology, 2021 The yeast RAVE (Regulator of H+-ATPase of Vacuolar and Endosomal membranes) complex and Rabconnectin-3 complexes of higher eukaryotes regulate acidification of organelles such as lysosomes and endosomes by catalyzing V-ATPase assembly.
Michael C. Jaskolka +2 more
doaj +1 more source
ADP Inhibition of Myosin V ATPase Activity [PDF]
Biophysical Journal, 2000 The kinetic mechanism of myosin V is of great interest because recent evidence indicates that the two-headed myosin V molecule functions as a processive motor, i.e., myosin V is capable of moving along an actin filament for many catalytic cycles of the motor without dissociating.
De La Cruz, Enrique M. +2 more
openaire +2 more sources
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK [PDF]
, 2019 Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how aldolase transmits lack of occupancy by FBP to AMPK activation remains unclear.
Changchuan Xie +34 more
core +5 more sources
EBioMedicine, 2019 Background: Cancer cells use specific V-ATPase subunits to activate oncogenic pathways. Therefore, we investigated V-ATPase deregulation in aggressive gliomas and associated signaling.
Andrea Terrasi +11 more
doaj +1 more source
The Mechanochemistry of V-ATPase Proton Pumps [PDF]
Biophysical Journal, 2000 The vacuolar H(+)-ATPases (V-ATPases) are a universal class of proton pumps that are structurally similar to the F-ATPases. Both protein families are characterized by a membrane-bound segment (V(o), F(o)) responsible for the translocation of protons, and a soluble portion, (V(1), F(1)), which supplies the energy for translocation by hydrolyzing ATP ...
Grabe, Michael +2 more
openaire +2 more sources
Autophagy Reports, 2022 A significant number of follicular lymphoma patients display recurrent mutations in subunits and regulators of the vacuolar-type H+-translocating ATPase (V-ATPase). Past studies focusing on the role of these mutations highlighted essential functions of macroautophagy/autophagy, amino-acid, and nutrient-sensing pathways in the pathogenesis of this ...
Ying Yang +2 more
openaire +3 more sources