Recombinant Vaccine–Derived Poliovirus in Madagascar [PDF]
Emerging Infectious Diseases, 2003 To the Editor: Between October 2001 and April 2002, five cases of acute flaccid paralysis associated with vaccine-derived poliovirus (VDPV) type 2 isolates were reported in the southern province of the Republic of Madagascar. The first patient, an 11-year-old child from the urban district of Toliara, first experienced paralysis on October 29, 2001 ...
Dominique Rousset +7 more
doaj +5 more sources
Evolution of Circulating Wild Poliovirus and of Vaccine-Derived Poliovirus in an Immunodeficient Patient: a Unifying Model [PDF]
Journal of Virology, 2000 ABSTRACT We determined nucleotide sequences of the VP1 and 2AB genes and portions of the 2C and 3D genes of two evolving poliovirus lineages: circulating wild viruses of T geotype and Sabin vaccine-derived isolates from an immunodeficient patient.
Gene V. Gavrilin +4 more
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Excretion of Wild-Type and Vaccine-Derived Poliovirus in the Feces of Poliovirus Receptor-Transgenic Mice [PDF]
Journal of Virology, 2003 ABSTRACT The emergence of circulating vaccine-derived poliovirus (cVDPV) strains in suboptimally vaccinated populations is a serious threat to the global poliovirus eradication. The genetic determinants for the transmissibility phenotype of polioviruses, and in particularly of cVDPV strains, are currently unknown.
Hein J. Boot +3 more
openalex +5 more sources
Implications of a Circulating Vaccine-Derived Poliovirus in Nigeria [PDF]
New England Journal of Medicine, 2010 The largest recorded outbreak of a circulating vaccine-derived poliovirus (cVDPV), detected in Nigeria, provides a unique opportunity to analyze the pathogenicity of the virus, the clinical severity of the disease, and the effectiveness of control measures for cVDPVs as compared with wild-type poliovirus (WPV).We identified cases of acute flaccid ...
Helen E. Jenkins +12 more
openalex +4 more sources
Estimating the Extent of Vaccine-Derived Poliovirus Infection
PLoS ONE, 2008 Eight outbreaks of paralytic polio attributable to circulating vaccine-derived poliovirus (cVDPV) have highlighted the risks associated with oral poliovirus vaccine (OPV) use in areas of low vaccination coverage and poor hygiene. As the Polio Eradication Initiative enters its final stages, it is important to consider the extent to which these viruses ...
Alison Wringe +3 more
openalex +6 more sources
Circulation of Type 1 Vaccine-Derived Poliovirus in the Philippines in 2001 [PDF]
Journal of Virology, 2004 ABSTRACT In 2001, highly evolved type 1 circulating vaccine-derived poliovirus (cVDPV) was isolated from three acute flaccid paralysis patients and one contact from three separate communities in the Philippines. Complete genomic sequencing of these four cVDPV isolates revealed that the capsid region was derived from the Sabin 1 vaccine strain
Hiroyuki Shimizu +15 more
openalex +4 more sources
Achieving High Poliovirus Antibody Seroprevalence in Areas at Risk of Vaccine-Derived Poliovirus Transmission—Niger Experience [PDF]
Open Forum Infectious Diseases, 2021 Abstract Background Outbreaks of vaccine-derived poliovirus type 2 (VDPV2) continue to expand across Africa. We conducted a serological survey of polio antibodies in high–polio risk areas of Niger to assess risk of poliovirus outbreaks. Methods
Sani Ousmane +8 more
openalex +4 more sources
A Large Vaccine‐Derived Poliovirus Outbreak on Madura Island—Indonesia, 2005 [PDF]
The Journal of Infectious Diseases, 2008 Between June and October 2005, 45 laboratory-confirmed type 1 vaccine-derived poliovirus (VDPV) cases were identified on Madura Island in Indonesia. Genetic sequencing data on VDPV isolates were consistent with replication and circulation for up to approximately 2 years.
Concepción F. Estívariz +10 more
openalex +3 more sources
Immunity levels to poliovirus in Lao children and adults before the vaccine-derived poliovirus outbreak: A retrospective study. [PDF]
PLoS ONE, 2018 In 2015, several provinces in Lao People's Democratic Republic (Lao PDR) experienced a vaccine-derived poliovirus outbreak. This survey was conducted (i) to evaluate the vaccination coverage in different settings and cohorts using the seroprevalence of ...
Maude Pauly +11 more
doaj +3 more sources
Importation and Circulation of Vaccine-Derived Poliovirus Serotype 2, Senegal, 2020–2021
Emerging Infectious Diseases, 2022 Environmental surveillance for poliovirus is increasingly used in poliovirus eradication efforts as a supplement to acute flaccid paralysis (AFP) surveillance. Environmental surveillance was officially established in 2017 in Senegal, where no poliovirus
Martin Faye +13 more
doaj +3 more sources