Results 91 to 100 of about 3,030,606 (198)

Outbreak of Poliomyelitis in Hispaniola Associated with Circulating Type 1 Vaccine-Derived Poliovirus [PDF]

Science, 2002
An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000–2001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very low (7 to 40%) rates of coverage with oral ...
Kew, O, Morris-Glasgow, V, Landaverde, M, Burns, C, Shaw, J, Garib, Z, Andre, J, Blackman, E, Freeman, CJ, Jorba, J, Sutter, R, Tambini, G, Venczel, L, Pedreira, C, Laender, F, Shimizu, H, Yoneyama, T, Miyamura, T, van der Avoort, Hrivm, Oberste, MS, Kilpatrick, D, Cochi, S, Pallansch, M, de Quadros, C   +23 more
openaire   +3 more sources

Vaccine [PDF]

Concurrent outbreaks of circulating vaccine-derived poliovirus serotypes 1 and 2 (cVDPV1, cVDPV2) were confirmed in the Republic of the Philippines in September 2019 and were subsequently confirmed in Malaysia by early 2020.

core   +4 more sources

Poliovirus excretion following vaccination with live poliovirus vaccine in patients with primary immunodeficiency disorders: clinicians’ perspectives in the endgame plan for polio eradication

BMC Research Notes, 2018
Objective Primary immunodeficiency (PID) patients are prone to developing viral infections and should not be vaccinated with live vaccines. In such patients, prolonged excretion and viral divergence may occur and they may subsequently act as reservoirs ...
Nermeen M. Galal, Safaa Meshaal, Rabab ElHawary, Eman Nasr, Laila Bassiouni, Humayun Ashghar, Noha H. Farag, Ondrej Mach, Cara Burns, Jane Iber, Qi Chen, Aisha ElMarsafy   +11 more
doaj   +1 more source

Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies

MedComm, Volume 7, Issue 6, June 2026.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge, Liu Yu, Jiahe Lu, Aihetaimujiang Anwaier, Xiyue Xiao, Yonghao Chen, Dingwei Ye, Hailiang Zhang, Wenhao Xu, Wenbin Dai   +9 more
wiley   +1 more source

Decay of Sabin inactivated poliovirus vaccine (IPV)-boosted poliovirus antibodies [PDF]

, 2015
IntroductionWe conducted a follow-on study to a phase I randomized, controlled trial conducted in Cuba, 2012, to assess the persistence of poliovirus antibodies at 21–22months following booster dose of Sabin-IPV compared to Salk-IPV in adults who had ...
Fonseca, Magile, Sein, Carolyn, Resik, Sonia, Tejeda, Alina, Okayasu, Hiromasa, Sutter, Roland W., Hung, Lai Heng, Diaz, Manuel, Martinez, Yenisleidys   +8 more
core   +1 more source

The Tumor Immune Microenvironment in Endometrial Cancer: Composition, Molecular Subtypes, and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Endometrial cancer (EC), a major gynecologic malignancy and a representative “cold tumor”, exhibits a tumor immune microenvironment (TIME) influenced by a broad range of cellular and molecular elements, immunosuppressive signals, and pathways of immune evasion.
Jingxuan Ye, Yashi Shi, Alexander Mustea, Xiaodan Mao, Pengming Sun   +4 more
wiley   +1 more source

Research Progress Towards Poliovirus Virus-like Particle Vaccines: A Review

Vaccines
Poliovirus (PV), a historically significant enterovirus responsible for severe paralytic diseases, has seen its incidence dramatically reduced through widespread vaccination efforts, propelling global eradication initiatives.
Taoli Han, Jinbo Xiao, Shiyao Zhang, Tongyue Su, Yinuo Liu, Yong Zhang   +5 more
doaj   +1 more source

When Public Health Becomes the Weapon: Current and Prospective Consequences of the Genocide in Gaza

World Medical &Health Policy, Volume 18, Issue 2, June 2026.
ABSTRACT Catastrophic humanitarian conditions during the 2023–2025 genocide in Gaza have caused a public health crisis of exceptional magnitude. This article summarizes key short‐ and long‐term health consequences for Gaza's civilian population and outlines priorities for recovery.
Therese Alexandra Evald, Nanna Gram Ahlmark, Clara Barfod Parellada, Andreea Micula, Caroline Klint Johannesen, Dana Bdier, Fayez Mahamid, Hilde Lausund, Jane Brandt Sørensen, Maha Aon, Majd Qannita, Maren Johanne Heilskov Rytter, Nanna Maaløe, Nina Jøranson, Sara Aakre Faradonbeh, Vibeke Brix Christensen, Waseem Alzaanin, Sigurd Lauridsen, Helle Timm, Frederik Schou‐Juul   +19 more
wiley   +1 more source

Emergence of vaccine-derived polioviruses, Democratic Republic of Congo, 2004-2011 [PDF]

, 2013
Polioviruses isolated from 70 acute flaccid paralysis patients from the Democratic Republic of Congo (DRC) during 2004–2011 were characterized and found to be vaccine- derived type 2 polioviruses (VDPV2s).
Mark Pallansch, de Gourville, Esther, Schoub, Barry D., Marietjie Venter, Puren, Adrian, Riziki Yogolelo, Olivia Lentsoane, Yogolelo, Riziki, Adrian Puren, Muyembe-Tamfum, Jean Jacques, Barry D. Schoub, Lentsoane, Olivia, Nicksy Gumede, Burns, Cara C., Cara C. Burns, Venter, Marietjie, Gumede, Nicksy, Pallansch, Mark, Esther de Gourville, Jean Jacques Muyembe-Tamfum   +19 more
core   +1 more source

Role of a Synonymous Mutation at Codon 178 in P1 That Attenuates Potato Virus Y‐Induced Tobacco Vein Necrosis and Its Application for Expressing Human Interferon

Molecular Plant Pathology, Volume 27, Issue 6, June 2026.
A synonymous mutation at P1 K178 attenuates PVY virulence and abolishes tobacco vein necrosis. This attenuated vector serves as a high‐efficiency plant bioreactor for the production and purification of recombinant human interferons. ABSTRACT Plant virus‐based vectors are gaining significant attention as bioreactors for recombinant protein production ...
De‐Guo Liu, Yue‐Yue Wang, Qing Zhu, Xin‐Wei Huang, Xi‐Ying Yan, Meng‐Ao Jia, Yu‐Shuang Guo, Ling‐Gai Cao, Jun Jiang, Xiang‐Dong Li, Xiao‐Lian Zhang, Yan‐Ping Tian   +11 more
wiley   +1 more source