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Microneedles: A New Generation Vaccine Delivery System

Micromachines, 2021
Transdermal vaccination route using biodegradable microneedles is a rapidly progressing field of research and applications. The fear of painful needles is one of the primary reasons most people avoid getting vaccinated.
Susu Zughaier, Rikhav Praful Gala, Priyal Bagwe   +2 more
exaly   +3 more sources

The role and prospects of extracellular vesicles in advanced drug and vaccine delivery [PDF]

Frontiers in Immunology
Extracellular vesicles (EVs) have emerged as natural nanoscale carriers with exceptional biocompatibility, target specificity, and drug-loading capabilities, positioning them as promising tools in the field of drug and vaccine delivery.
Defa Huang, Haibin Shen, Qing Jin, Tao Chen, Yuhuan Xie, Dingyu Rao, Meijin Liu   +6 more
doaj   +2 more sources

Assessing the Feasibility of Drone‐Mediated Vaccine Delivery: An Exploratory Study [PDF]

Health Science Reports
Background and Aims In the past decade, unmanned aerial systems (UASs), commonly known as drones, have found applications not only in military and agriculture but also in the transportation of medical supplies.
Sumit Aggarwal, Prakamya Gupta, Sivaraman Balaji, Saurabh Sharma, Ajoy Kanti Ghosh, Simmy, Balram Bhargava, Samiran Panda   +7 more
doaj   +2 more sources

Beyond Needles: Immunomodulatory Hydrogel-Guided Vaccine Delivery Systems [PDF]

Gels
Vaccines are critical for combating infectious diseases, saving millions of lives worldwide each year. Effective immunization requires precise vaccine delivery to ensure proper antigen transport and robust immune activation.
Md Mohosin Rana, Cigdem Demirkaya, Hector De la Hoz Siegler   +2 more
doaj   +2 more sources

Microneedle Delivery of an Adjuvanted Microparticulate Vaccine Induces High Antibody Levels in Mice Vaccinated against Coronavirus

Vaccines, 2022
This ‘proof-of-concept’ study aimed to test the microparticulate vaccine delivery system and a transdermal vaccine administration strategy using dissolving microneedles (MN).
Sharon Vijayanand, Smital Patil, Devyani Joshi, Ipshita Menon, Keegan Braz Gomes, Akanksha Kale, Priyal Bagwe, Shadi Yacoub, Mohammad N. Uddin, Martin J. D’Souza   +9 more
doaj   +1 more source

Adjuvanted-SARS-CoV-2 Spike Protein-Based Microparticulate Vaccine Delivered by Dissolving Microneedles Induces Humoral, Mucosal, and Cellular Immune Responses in Mice

Pharmaceuticals, 2023
COVID-19 continues to cause an increase in the number of cases and deaths worldwide. Due to the ever-mutating nature of the virus, frequent vaccination against COVID-19 is anticipated.
Smital Patil, Sharon Vijayanand, Ipshita Menon, Keegan Braz Gomes, Akanksha Kale, Priyal Bagwe, Shadi Yacoub, Mohammad N. Uddin, Martin J. D’Souza   +8 more
doaj   +1 more source

Zika Vaccine Microparticles (MPs)-Loaded Dissolving Microneedles (MNs) Elicit a Significant Immune Response in a Pre-Clinical Murine Model

Vaccines, 2023
Although the global Zika epidemic in 2015–16 fueled vaccine development efforts, there is no approved Zika vaccine or treatment available to date. Current vaccine platforms in clinical trials are administered via either subcutaneous or intramuscular ...
Akanksha Kale, Devyani Joshi, Ipshita Menon, Priyal Bagwe, Smital Patil, Sharon Vijayanand, Keegan Braz Gomes, Mohammad N. Uddin, Martin J. D’Souza   +8 more
doaj   +1 more source

Dissolving Microneedles Loaded with Nanoparticle Formulation of Respiratory Syncytial Virus Fusion Protein Virus-like Particles (F-VLPs) Elicits Cellular and Humoral Immune Responses

Vaccines, 2023
Respiratory syncytial virus (RSV) is one of the leading causes of bronchiolitis and pneumonia in children ages five years and below. Recent outbreaks of the virus have proven that RSV remains a severe burden on healthcare services.
Ipshita Menon, Smital Patil, Priyal Bagwe, Sharon Vijayanand, Akanksha Kale, Keegan Braz Gomes, Sang Moo Kang, Martin D’Souza   +7 more
doaj   +1 more source

Transdermal Immunization with Microparticulate RSV-F Virus-like Particles Elicits Robust Immunity

Vaccines, 2022
No approved vaccines against respiratory syncytial virus (RSV) infections exist to date, due to challenges arising during vaccine development. There is an unmet need to explore novel approaches and a universal strategy to prevent RSV infections. Previous
Sucheta D’Sa, Kimberly Braz Gomes, Grace Lovia Allotey-Babington, Cemil Boyoglu, Sang-Moo Kang, Martin J. D’Souza   +5 more
doaj   +1 more source

An Adjuvanted Inactivated SARS-CoV-2 Microparticulate Vaccine Delivered Using Microneedles Induces a Robust Immune Response in Vaccinated Mice

Pharmaceutics, 2023
SARS-CoV-2, the causal agent of COVID-19, is a contagious respiratory virus that frequently mutates, giving rise to variant strains and leading to reduced vaccine efficacy against the variants.
Sharon Vijayanand, Smital Patil, Ipshita Menon, Keegan Braz Gomes, Akanksha Kale, Priyal Bagwe, Mohammad N. Uddin, Susu M. Zughaier, Martin J. D’Souza   +8 more
doaj   +1 more source