Results 11 to 20 of about 131,172 (214)

Transdermal Vaccination with the Matrix-2 Protein Virus-like Particle (M2e VLP) Induces Immunity in Mice against Influenza A Virus

Vaccines, 2021
In this study, our goal was to utilize the extracellular domain matrix-2 protein virus-like particle (M2e VLP) that has been found to be highly conserved amongst all strains of influenza and could serve as a potential vaccine candidate against influenza.
Kimberly Braz Gomes, Sucheta D’Sa, Grace Lovia Allotey-Babington, Sang-Moo Kang, Martin J. D’Souza   +4 more
doaj   +1 more source

Enhanced Immunogenicity of an Influenza Ectodomain Matrix-2 Protein Virus-like Particle (M2e VLP) Using Polymeric Microparticles for Vaccine Delivery

Viruses, 2022
In this study, we demonstrate how encapsulating a conserved influenza ectodomain matrix-2 protein virus-like particle (M2e5x VLP) into a pre-crosslinked bovine serum albumin (BSA) polymeric matrix enhances in vitro antigen immunogenicity and in vivo ...
Keegan Braz Gomes, Ipshita Menon, Priyal Bagwe, Lotika Bajaj, Sang-Moo Kang, Martin J. D’Souza   +5 more
doaj   +1 more source

Lipid-Based Drug Delivery Systems for Diseases Managements

Biomedicines, 2022
Liposomes are tiny lipid-based vesicles composed of one or more lipid bilayers, which facilitate the encapsulation of hydrophilic, lipophilic, and amphiphilic biological active agents.
Douweh Leyla Gbian, Abdelwahab Omri
doaj   +1 more source

GLOBAL AND REGIONAL BURDEN OF ATTRIBUTABLE AND ASSOCIATED BACTERIAL ANTIMICROBIAL RESISTANCE AVERTABLE BY VACCINATION: MODELLING STUDY

International Journal of Infectious Diseases, 2023
Intro: Antimicrobial resistance (AMR) is a global health threat with 1.27 million deaths attributable to bacterial AMR and 4.95 million deaths associated with bacterial AMR in 2019.
C. Kim, M. Holm, I. Frost, M. Hasso-Agopsowicz, K. Abbas   +4 more
doaj   +1 more source

The Impact of an Efflux Pump Inhibitor on the Activity of Free and Liposomal Antibiotics against Pseudomonas aeruginosa

Pharmaceutics, 2021
The eradication of Pseudomonas aeruginosa in cystic fibrosis patients has become continuously difficult due to its increased resistance to treatments.
Douweh Leyla Gbian, Abdelwahab Omri
doaj   +1 more source

Meningococcal Vaccines: Challenges and Prospects

Vaccines, 2020
Neisseria meningitidis is a gram-negative bacterium that causes a severe acute infection, called the meningococcal disease [...]
Priyal Bagwe, Lotika Bajaj, Rikhav Gala, Susu M. Zughaier, Mohammad N. Uddin, Martin J. D’Souza   +5 more
doaj   +1 more source

Leveraging immunoliposomes as nanocarriers against SARS-CoV-2 and its emerging variants

Asian Journal of Pharmaceutical Sciences, 2023
The global COVID-19 pandemic arising from SARS-CoV-2 has impacted many lives, gaining interest worldwide ever since it was first identified in December 2019. Till 2023, 752 million cumulative cases and 6.8 million deaths were documented globally.
Nur Dini Fatini Mohammad Faizal, Nurul Afina Ramli, Nur Najihah Izzati Mat Rani, Nur Adania Shaibie, Aarti, Pattaporn Poonsawas, Sunil K. Sharma, Mohd Cairul Iqbal Mohd Amin   +7 more
doaj   +1 more source

Assessment of In Vitro Immunostimulatory Activity of an Adjuvanted Whole-Cell Inactivated Neisseria gonorrhoeae Microparticle Vaccine Formulation

Vaccines, 2022
The emergence of drug-resistant gonorrhea infections worldwide combined with the lack of a vaccine is alarming. We prepared a novel microparticulate (MP) vaccine formulation using whole-cell inactivated Neisseria gonorrhoeae as the vaccine antigen, with ...
Priyal Bagwe, Lotika Bajaj, Rikhav P. Gala, Martin J. D‘Souza, Susu M. Zughaier   +4 more
doaj   +1 more source

Delivery of PLGA-Loaded Influenza Vaccine Microparticles Using Dissolving Microneedles Induces a Robust Immune Response

Pharmaceutics
Background: Influenza virus is one of the major respiratory virus infections that is a global health concern. Although there are already approved vaccines, most are administered via the intramuscular route, which is usually painful, leading to vaccine ...
Emmanuel Adediran, Tanisha Arte, Dedeepya Pasupuleti, Sharon Vijayanand, Revanth Singh, Parth Patel, Mahek Gulani, Amarae Ferguson, Mohammad Uddin, Susu M. Zughaier, Martin J. D’Souza   +10 more
doaj   +1 more source

Buccal Administration of a Zika Virus Vaccine Utilizing 3D-Printed Oral Dissolving Films in a Mouse Model

Vaccines
Over the years, research regarding the Zika virus has been steadily increasing. Early immunization for ZIKV is a priority for preventing complications such as microencephaly and Guillain–Barré syndrome (GBS).
Sarthak Shah, Parth Patel, Amarae Ferguson, Priyal Bagwe, Akanksha Kale, Emmanuel Adediran, Revanth Singh, Tanisha Arte, Dedeepya Pasupuleti, Mohammad N. Uddin, Martin D’Souza   +10 more
doaj   +1 more source