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Meningococcal Vaccines and Vaccine Developments
2003Despite rapid advances in the diagnosis of bacterial infections and the availability of effective antibiotics, meningococcal disease continues to represent a substantial public health problem for most countries (1-4). Disease usually develops rapidly, is notoriously difficult to distinguish from other febrile illnesses, and generally has a high case ...
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Vaccine Development for Cytomegalovirus
2018The development of a cytomegalovirus (CMV) vaccine has become a top priority due to its potential cost-effectiveness and associated public health benefits. However, there are a number of challenges facing vaccine development including the following: (1) CMV has many mechanisms for evading immune responses , and natural immunity is not perfect, (2) the ...
Naoki, Inoue +3 more
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Development of combination vaccines
Vaccine, 1999Breakthroughs in molecular biology, biochemistry, process development, immunology and related fields have provided the means for improving current vaccines and developing new ones. The increasing availability of these vaccines is providing the unprecedented opportunity to prevent serious infectious disease in different age groups and to significantly ...
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Development of vaccines for coccidioidomycosis
Mycopathologia et Mycologia Applicata, 1970A most compelling stimulus to investigate the influence of actively-induced immunity in experimental coccidioidomycosis is found in the epidemiologic studies ofSmith (35) andSmith et al. (37–39). Their serologic and skin test surveys among residents in areas of coccidioidal endemicity directed attention to a role apparently played by actively-acquired ...
H B, Levine, D, Pappagianis, J M, Cobb
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2011
In this chapter we discuss vaccines to protect against the highly toxic plant-derived toxin, ricin. Due to its prevalence, ease of use, and stability it has been used in sporadic incidents of espionage. There is also concern that it will be used as an agent of bioterrorism.
Joan E, Smallshaw, Ellen S, Vitetta
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In this chapter we discuss vaccines to protect against the highly toxic plant-derived toxin, ricin. Due to its prevalence, ease of use, and stability it has been used in sporadic incidents of espionage. There is also concern that it will be used as an agent of bioterrorism.
Joan E, Smallshaw, Ellen S, Vitetta
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Frontiers in Bioscience, 2005
For the past two decades, scientists have aggressively pursued the development of a vaccine against human immunodeficiency virus (HIV). The magnitude of this effort is unprecedented in the history of infectious diseases. However, difficulties in finding promising candidate vaccines have limited the number of clinical efficacy trials.
Mahender, Singh +2 more
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For the past two decades, scientists have aggressively pursued the development of a vaccine against human immunodeficiency virus (HIV). The magnitude of this effort is unprecedented in the history of infectious diseases. However, difficulties in finding promising candidate vaccines have limited the number of clinical efficacy trials.
Mahender, Singh +2 more
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The Development of Biosynthetic Vaccines
1989Publisher Summary This chapter presents the systems available for the biological production of subunit immunogens and discussed their application to vaccine development for select bacterial and viral pathogens. A biosynthetic vaccine is a formulation containing a noninfectious, protective subunit immunogen that is produced in or by a biologic system.
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Malaria vaccines in development
Expert Opinion on Emerging Drugs, 2005The recent infusion of public and private funding for malaria vaccine development has greatly accelerated the pace at which candidate malaria vaccines are entering the clinic. Recent promising results from vaccine trials carried out in malaria-naive and -endemic populations have revealed important insights into what will be required of a successful ...
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Vaccine development reconsidered
Vaccine, 1988This paper briefly reviews work on vaccine development since the early 1950s with special emphasis on identification of immunogens and their presentation to the host so as to elicit an immune response. This is illustrated primarily by a discussion of the development of a candidate meningococcal B vaccine based on a capsular carbohydrate outer membrane ...
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Development of babesial vaccines
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1989The most widely used vaccine against cattle babesiosis was blood from a carrier animal. The development of a calf passage attenuated strain in Australia was a great improvement in vaccine safety and efficacy. The degree of immunity generated by this vaccine remains a standard against which to compare other vaccines.
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