Results 1 to 10 of about 435,123 (230)

Heterogeneity in malaria exposure and vaccine response: implications for the interpretation of vaccine efficacy trials [PDF]

Malaria Journal, 2010
Background Phase III trials of the malaria vaccine, RTS, S, are now underway across multiple sites of varying transmission intensity in Africa. Heterogeneity in exposure, vaccine response and waning of efficacy may bias estimates of vaccine efficacy ...
Drakeley Chris J, Griffin Jamie T, White Michael T, Ghani Azra C   +3 more
doaj   +5 more sources

COVID-19 Vaccine Efficacy

Pakistan Journal of Medical Research, 2023
The highly contagious SARS-CoV-2, (COVID-19), has put huge pressure on the health-care system worldwide. In order to trick the immune system into producing response different vaccines varying technologies have been developed.
Nighat Murad
doaj   +5 more sources

Immunogenicity as a Predictor of Influenza Vaccine Efficacy: A Systematic Review [PDF]

Vaccines
Background/Objectives: Influenza represents a significant burden on global public health, and vaccination is the most effective strategy to reduce it.
André Miguel Martins, Luis Félix Valero Juan, Marlene Santos, João P. Martins   +3 more
doaj   +2 more sources

Symmetric Vaccine Efficacy [PDF]

Traditional measures of vaccine efficacy (VE) are inherently asymmetric, constrained above by $1$ but unbounded below. As a result, VE estimates and corresponding confidence intervals can extend far below zero, making interpretation difficult and potentially obscuring whether the apparent effect reflects true harm or simply statistical uncertainty. The
McGowan, Lucy D'Agostino, Lotspeich, Sarah C., Hudgens, Michael G.   +2 more
openaire   +3 more sources

SARS-CoV-2 vaccines: Clinical endpoints and psychological perspectives: A literature review

Journal of Infection and Public Health, 2022
Background: About 270 million cases have been confirmed, and 5.3 million fatalities Worldwide due to SARS-CoV-2. Several vaccine candidates have entered phase 3 of the clinical trial and are being investigated to provide immunity to the maximum ...
Jonaid Ahmad Malik, Mir Aroosa, Sakeel Ahmed, Mrunal Shinde, Saleh Alghamdi, Khaled Almansour, Turki Al Hagbani, Muteb Sultan Alanazi, Sirajudheen Anwar   +8 more
doaj   +1 more source

Envelope Determinants of Equine Lentiviral Vaccine Protection [PDF]

, 2013
Lentiviral envelope (Env) antigenic variation and associated immune evasion present major obstacles to vaccine development. The concept that Env is a critical determinant for vaccine efficacy is well accepted, however defined correlates of protection ...
A Kumar, A Kumar, AJ Mcmichael, AT Das, B Berkhout, BA Sponseller, BF Haynes, C Leroux, C Leroux, C Leroux, CH Grund, Charles J. Issel, CJ Issel, Corin Ezzelarab, D Shental-Bechor, David Horohov, DC Montefiori, DL Lichtenstein, DL Lichtenstein, EW Uhl, F Li, F Li, F Li, J Mills, JB Whitney, JK Craigo, JK Craigo, JK Craigo, JK Craigo, JK Craigo, JK Craigo, JK Craigo, JK Craigo, JM Ball, Jodi K. Craigo, K Abel, KA Hussain, L Coggins, L Howe, L Howe, Liu Chong, M Busch, MJ Papandreou, ML Raabe, MR Raabe, MR Reynolds, N Almond, PM Rwambo, PM Rwambo, R Hofmann-Lehmann, RC Montelaro, RF Cook, RM Ruprecht, Ronald C. Montelaro, RP Johnson, RP Johnson, RP Johnson, RR Amara, S Hambleton, SA Hammond, SA Hammond, SA Hammond, Sheila J. Cook, SL Payne, SM Blower, SM Harrold, SZ Wang, TL Tagmyer, TL Tagmyer, TW Baba, TW Baba, WC Koff, WM Bogers, Y Kono, YH Zheng, YH Zheng, Zhiping Ye   +76 more
core   +13 more sources

Screening immune adjuvants for an inactivated vaccine against Erysipelothrix rhusiopathiae

Frontiers in Veterinary Science, 2022
In this study, we screened adjuvants for an inactivated vaccine against Erysipelothrix rhusiopathiae (E. rhusiopathiae). Inactivated cells of E. rhusiopathiae strain HG-1 were prepared as the antigen in five adjuvanted inactivated vaccines, including a ...
Li-Jun Guan, Li-Jun Guan, Shi-Xuan Pei, Ji-Jian Song, Peng-Fei Zhan, Yi-Nong Han, Yun Xue, Ke Ding, Zhan-Qin Zhao   +8 more
doaj   +1 more source

Effect of human rotavirus vaccine on severe diarrhea in African infants. [PDF]

, 2010
BACKGROUND: Rotavirus is the most common cause of severe gastroenteritis among young children worldwide. Data are needed to assess the efficacy of the rotavirus vaccine in African children.
Cheuvart, Brigitte B, Cunliffe, Nigel A, Gillard, Paul H, Han, Htay H, Kirsten, Mari, Louw, Cheryl, Madhi, Shabir A, Neuzil, Kathleen M, Ngwira, Bagrey, Steele, Duncan, Victor, John C, Witte, Desirée   +11 more
core   +5 more sources

Communication about vaccine efficacy and COVID-19 vaccine choice: Evidence from a survey experiment in the United States.

PLoS ONE, 2022
While mass vaccination campaigns against COVID-19 have inoculated almost 200 million Americans and billions more worldwide, significant pockets of vaccine hesitancy remain.
Sarah Kreps, Douglas L Kriner
doaj   +1 more source

Knowledge and perception regarding effectiveness in influenza vaccines among General Practitioners in Germany: A national survey

Vaccine: X, 2022
Objectives: To understand physicians’ knowledge and perception regarding the effectiveness of influenza vaccines and to communicate the importance of understanding the differences in terms of vaccine efficacy and vaccine effectiveness.
Sanjay Hadigal, Joseph Cook
doaj   +1 more source