Results 31 to 40 of about 495,603 (297)

A DNA vaccine construct incorporating intercellular trafficking and intracellular targeting motifs effectively primes and induces memory B and T cell responses in outbred animals [PDF]

, 2007
We developed a vaccine construct in which a BVP22 domain and an invariant-chain major histocompatibility complex class II-targeting motif capable of enhancing dendritic cell antigen uptake and presentation were fused to a sequence encoding a B- and T ...
Palmer, Guy H, Zhuang, Yan, Mwangi, W, Howard, CJ, Aida, Yoko, Hunter, Beverly J, Splitter, Gary A, Brown, WC, Palmer, GH, Hunter, BJ, Aida, Y, Davies, Christopher J, Brown, Wendy C, Davies, CJ, Mwangi, Waithaka, Splitter, GA, Zhuang, Y, Hope, Jayne; id_orcid, Howard, Chris J, Hope, Jayne C   +19 more
core   +1 more source

Primary and booster immune responses to SA14-14-2 Japanese encephalitis vaccine in Korean infants

, 1999
Attenuated SA14-14-2 Japanese encephalitis (JE) vaccine has been administered safely and effectively to more than 100 million children in China since 1988 and recently, licensure of the vaccine in Korea has been sought.
박민수
core   +1 more source

Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis

, 2020
Tuberculosis still claims more lives than any other pathogen, and a vaccine better than BCG is urgently needed. One of the challenges for novel TB vaccines is to protect against all Mycobacterium tuberculosis lineages, including the most virulent ones ...
권기웅, 신성재
core   +1 more source

Enhancing enterovirus A71 vaccine production yield by microcarrier profusion bioreactor culture

, 2017
[[abstract]]Hand, foot and mouth diseases (HFMD) are mainly caused by Enterovirus A71 (EV-A71) infections. Clinical trials in Asia conducted with formalin-inactivated EV-A71 vaccine candidates produced from serum-free Vero cell culture using either ...
Liu, CC;Wu, SC;Wu, SR;Lin, HY;Guo, MS;Hu, AYC;Chow, YH;Chiang, JR;Shieh, DB;Chong, P
core   +1 more source

Utilisation of monoclonal antibodies in the single radial immunodiffusion assay to determine potency and stability for seasonal and pandemic influenza vaccines

Frontiers in Immunology
IntroductionFollowing manufacture, influenza vaccines are required to undergo potency testing as part of the release process to market. The single radial immunodiffusion (SRID) assay is currently the compendial standard for determining the antigen ...
Jesse Bodle, David Burge, Gopal Gounder, Kirsten Vandenberg, Karen Laurie, Steven Rockman, Steven Rockman   +6 more
doaj   +1 more source

Research progress on substitution of in vivo method(s) by in vitro method(s) for human vaccine potency assays

Expert Review of Vaccines, 2023
Introduction Potency is a critical quality attribute for controlling quality consistency and relevant biological properties of vaccines. Owing to the high demand for animals, lengthy operations and high variability of in vivo methods, in vitro ...
Xuanxuan Zhang, Xing Wu, Qian He, Junzhi Wang, Qunying Mao, Zhenglun Liang, Miao Xu   +6 more
doaj   +1 more source

In silico design and evaluation of a multiepitope vaccine against Bordetella pertussis: structural, immunological, and biological properties

Genomics & Informatics
Introduction/objectives Despite widespread vaccination, the increasing incidence of pertussis underscores the urgent need for innovative vaccine strategies.
Negar Souod, Hamid Madanchi, Fariborz Bahrami, Saeed Reza Pakzad, Fereshteh Shahcheraghi, Soheila Ajdary   +5 more
doaj   +1 more source

Production of EV71 vaccine candidates

, 2012
[[abstract]]Enterovirus 71 (EV71) is now recognized as an emerging neurotropic virus in Asia and with Coxsackie virus (CV) it is the other major causative agent of hand-foot-mouth diseases (HFMD).
Chong, P;Hsieh, SY;Liu, CC;Chou, AH;Yuan, CJ;Wu, SC;Liu, SJ;Chow, YH;Su, IJ;Klein, M
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Cell-Based Relative Potency of a Respiratory Syncytial Virus mRNA Vaccine Correlates with In Vivo Immunogenicity

Vaccines
Background/Objectives: Potency is a critical quality attribute for vaccine development as well as clinical drug product (DP) lot release and stability testing.
Katrina Feller, Hesham Nawar, Liping Song, Amanda Abrams, Liang Shang, Ashley Gruber, Tatyana Yun, Hualin Helen Li   +7 more
doaj   +1 more source