Rapid In-Process Measurement of Live Virus Vaccine Potency Using Laser Force Cytology: Paving the Way for Rapid Vaccine Development [PDF]
Vaccines, 2022 Vaccinations to prevent infectious diseases are given to target the body’s innate and adaptive immune systems. In most cases, the potency of a live virus vaccine (LVV) is the most critical measurement of efficacy, though in some cases the quantity of ...
Reilly McCracken +10 more
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Development of a novel EV-A71 monoclonal antibody for monitoring vaccine potency. [PDF]
PLoS Neglected Tropical DiseasesEnterovirus A71 (EV-A71) is one of the major causes of hand, foot, and mouth disease (HFMD), primarily affecting children under five. It can lead to neurological and cardiac complications, or even death, in some cases.
Thi-Hong-Loc Le +4 more
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VaccinesBackground/Objectives: A preventative vaccine against human cytomegalovirus (HCMV) infection and disease remains an unmet medical need. Several attenuated virus and antigen-based HCMV vaccine candidates have been proposed; however, development challenges
Nicole M. Smiddy +12 more
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Monitoring the infectious titer of bOPV and the vaccine vial monitor stage at different storage temperature ranges [PDF]
Human Vaccines & ImmunotherapeuticsPoor storage of the polio vaccine in areas of inadequate or absent power to sustain the cold chain can compromise its potency. This study assessed the sustainability of bivalent Oral Polio vaccine (bOPV) potency using total viral titer and the color of ...
Mercy Doose Yough +5 more
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A time-resolved fluoroimmunoassay to assay the rabies virus glycoprotein: application for estimation of human rabies vaccine potency [PDF]
Scientific Reports, 2017 Replacement of the in vivo rabies vaccine potency test (NIH test) by in vitro methods had been discussed by several researcher including WHO expert working groups.
Guanfeng Lin +10 more
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Qualification of a quantitative stability indicating potency assay for mRNA-LNP vaccine candidates [version 1; peer review: awaiting peer review] [PDF]
Gates Open ResearchPotency assays assess the functional integrity of a target antigen to ensure that the final drug product is consistent between the commercial and clinical trial lots.
ANAN BZAMI +3 more
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Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix [PDF]
Advanced Science, EarlyView.Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song +5 more
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Archives of Razi Institute, 2012 Poliomyelitis, an acute viral infectious disease caused by poliovirus, still remains a public health problem in developing countries. Despite the global effort to eradicate polio, continuing the polio immunization with a potent and safe vaccine is ...
Soleimani, S.,, Abedi Kiasari, B.
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Potency Tests of Combination Vaccines [PDF]
Clinical Infectious Diseases, 2001 Combination vaccines differ from single-component vaccines in composition and in how they are manufactured, which poses significant challenges to implementing effective quality-control tests, including measurement of potency. Because each combination vaccine is unique, existing guidelines often fail to provide sufficient information to overcome the ...
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Vaccines, 2020 Since 2015, outbreaks of foot-and-mouth disease (FMD) in the Middle East have been caused by a new emerging viral lineage, A/ASIA/G-VII. Invitro vaccine matching data indicated that this virus poorly matched (low r1-value) with vaccines that were being ...
Aldo Dekker +7 more
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