Results 181 to 190 of about 471,998 (303)

BCG Tokyo-172 Strain Vaccine [PDF]

, 2020
openaire   +1 more source

From Parallel Provision to Health System Integration: Exploring the Trajectory and Contextual Drivers of the Healthcare Response for Refugees in Six Low‐ and Middle‐Income Countries

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Rising numbers of refugees, prolonged displacement and reduced funding have led to challenges in terms of how to address their healthcare needs, with different approaches taken, ranging from parallel mechanisms to arrangements that are integrated (to different extents) within the national health system. Increasingly, global frameworks call for
Maria Paola Bertone, Natasha Palmer, Amina Olabi, Ibrahim Bou‐Orm, Hussam Rekani, Hassan Ould Moctar, Ricardo Chuquimia, Chitalu Miriam Chama‐Chiliba, Ben Ngoye, Zahid Ali Memon, Marcia Vera‐Espinoza, Karin Diaconu, Alastair Ager, Sophie Witter   +13 more
wiley   +1 more source

The 40Fp8 vaccine strain is safe and protects pregnant ewes from a virulent RVFV challenge. [PDF]

NPJ Vaccines
Borrego B, Alonso C, Moreno S, Calvo-Pinilla E, Lorenzo G, Sánchez-Cordón PJ, Brun A.   +6 more
europepmc   +1 more source

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

Live-attenuated influenza virus vaccine strain with an engineered temperature-sensitive and genetically stable viral polymerase variant. [PDF]

J Virol
Naito T, Ushirogawa H, Kunishio M, Yano H, Saito S, Higeuchi T, Fujita K, Saito M.   +7 more
europepmc   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

A BtpB-Deleted Brucella Vaccine Strain Provides Dual Advantages: Enhanced Protection and Diagnostic Differentiation Capability in Mice. [PDF]

Microb Biotechnol
Xu Z, Deng X, Gao H, Wang Y, Zhang H, Xu Y, He H, Wu A, Zhang Y, Yi J, Wang Z, Chen C, Ma Z.   +12 more
europepmc   +1 more source

Napabucasin transforms liver microenvironment and boosts immunotherapy efficacy by converting potential metastases into “hot” tumors

Interdisciplinary Medicine, EarlyView.
Napabucasin reduces liver metastases by reprogramming the hepatic microenvironment. It induces hepatocyte secretion of CCL21 via c‐Fos activation, recruiting lymphocytes and converting “cold” metastases into immunologically “hot” tumors. This effect is liver‐specific and independent of cancer cells.
Qiongqiong Wang, Jiaqi Zhou, Hang Qiao, Yifan Jia, Ling Ye, Zeli Li, Jiahe Ouyang, Haoxian Zhou, Kangxin Zeng, Xuemeng Wang, Yixian Wang, Yang Zhang, Yupeng Zhang, Yizhou Cai, Yutao Hu, Minzhe Zhang, Wenwei Xu, Zhenzhen Wu, Xiaofang Qiu, Li Lin   +19 more
wiley   +1 more source

An SNP-based diagnostic method for <i>Brucella</i> S2 vaccine strain infections. [PDF]

Front Vet Sci
Wang X, Tian X, Li W, Yang Y, Zhang S, Wang H, Geng W, Zhai J.   +7 more
europepmc   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source