Results 1 to 10 of about 1,439,979 (204)

MicroRNA-Attenuated Virus Vaccines [PDF]

Non-Coding RNA, 2018
Live-attenuated vaccines are the most effective way to establish robust, long-lasting immunity against viruses. However, the possibility of reversion to wild type replication and pathogenicity raises concerns over the safety of these vaccines. The use of
Elizabeth J. Fay, Ryan A. Langlois
doaj   +3 more sources

Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD

Gut, 2021
Objective Delayed second dose SARS-CoV-2 vaccination trades maximal effectiveness for a lower level of immunity across more of the population. We investigated whether patients with inflammatory bowel disease treated with infliximab have attenuated ...
Nicholas A. Kennedy, Simone Lin, James Goodhand   +2 more
exaly   +2 more sources

Natural Attenuated Vaccines for Pasteurella multocida [PDF]

Biology
Pasteurella multocida is capable of infecting various animal species, causing hemorrhagic septicemia or infectious pneumonia, and it is widely prevalent and pathogenic worldwide.
Qingyuan Xu, Lijun Guan, Yun Xue, Zhanqin Zhao   +3 more
doaj   +2 more sources

Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines

mBio, 2019
Nonstructural protein 1 (NS1) of influenza virus is a key virulence element with multifunctional roles in virus replication and a potent antagonist of host immune response.
Pui Wang, Min Zheng, Siu-Ying Lau, Pin Chen, Bobo Wing-Yee Mok, Siwen Liu, Honglian Liu, Xiaofeng Huang, Conor J. Cremin, Wenjun Song, Yixin Chen, Yik-Chun Wong, Haode Huang, Kelvin Kai-Wong To, Zhiwei Chen, Ningshao Xia, Kwok-Yung Yuen, Honglin Chen   +17 more
doaj   +2 more sources

Combination attenuation offers strategy for live-attenuated coronavirus vaccines [PDF]

Journal of Virology, 2018
AbstractWith an ongoing threat posed by circulating zoonotic strains, new strategies are required to prepare for the next emergent coronavirus (CoV). Previously, groups had targeted conserved coronavirus proteins as a strategy to generate live-attenuated vaccine strains against current and future CoVs.
Menachery, Vineet D., Gralinski, Lisa E., Mitchell, Hugh D., Dinnon III, Kenneth H., Leist, Sarah R., Yount Jr., Boyd L., McAnarney, Eileen T., Graham, Rachel L., Waters, Katrina M., Baric, Ralph S.   +9 more
openaire   +3 more sources

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

Nature, 2022
The recent emergence of B.1.1.529, the Omicron variant1,2, has raised concerns of escape from protection by vaccines and therapeutic antibodies. A key test for potential countermeasures against B.1.1.529 is their activity in preclinical rodent models of ...
Peter J Halfmann, Shun Iida, Kiyoko Iwatsuki-Horimoto   +2 more
exaly   +2 more sources

Research note: Comparison of live attenuated and non-attenuated Eimeria vaccines on safety following overdose administration using the European pharmacopoeia monograph model [PDF]

Poultry Science
Live non-attenuated and attenuated coccidiosis vaccines are available and induce a solid immune response to Eimeria spp. However, knowledge regarding the safety of live non-attenuated Eimeria vaccines is still limited.
Marc Pagès, Andreu Albó, Gregori Bech-Sàbat, Roser Morató, Joan Molist-Badiola, Martina Dardi   +5 more
doaj   +2 more sources

Research Progress in the Development of Vaccines Against Riemerella anatipestifer [PDF]

Microorganisms
Riemerella anatipestifer (R. anatipestifer, RA) is a globally distributed pathogen responsible for duck serositis, an acute multisystemic disease whose infection leads to substantial economic impacts in duck production.
Junxvan Lan, Shaopeng Wu, Lu Zhao, Fakai Li, Dongyi Xing, Fan Li, Hui Tian, Xiaoxue Yang, Shuhong Sun, Miaoli Wang   +9 more
doaj   +2 more sources

Biomarkers of safety and immune protection for genetically modified live attenuated Leishmania vaccines against visceral leishmaniasis-Discovery and implications

Frontiers in Immunology, 2014
Despite intense efforts there is no safe and efficacious vaccine against visceral leishmaniasis, which is fatal and endemic in many tropical countries. A major shortcoming in the vaccine development against blood borne parasitic agents such as Leishmania
Sreenivas eGannavaram, Ranadhir eDey, Kumar eAvishek, Angamuthu eSelvapandiyan, Poonam eSalotra, Hira eNakhasi   +5 more
doaj   +2 more sources

Quality control procedure for Coccidial vaccines versus different routes of immunization [PDF]

Veterinary World, 2022
Background and Aim: Coccidiosis is an enteric infection caused by a protozoon (Eimeria tenella). Coccidiosis is known to have a negative impact on the economy. Coccidiosis is controlled using anticoccidial drugs, antibiotics, and vaccines.
Arwa Elnaggar, Hala Mahmoud, Sahar Saber
doaj   +1 more source