Results 1 to 10 of about 64,283 (198)
MicroRNA-Attenuated Virus Vaccines [PDF]
Non-Coding RNA, 2018 Live-attenuated vaccines are the most effective way to establish robust, long-lasting immunity against viruses. However, the possibility of reversion to wild type replication and pathogenicity raises concerns over the safety of these vaccines. The use of host-derived microRNAs (miRNAs) to attenuate viruses has been accomplished in an array of ...
Elizabeth J. Fay, Ryan A. Langlois
openaire +4 more sources
Attenuated Vaccines for Augmented Immunity [PDF]
Cell Host & Microbe, 2017 Live attenuated vaccines are more immunogenic and have the capacity to elicit long-lasting immune responses. In two recent studies, Wang et al. (2017) and Si et al. (2016) describe strategies for the generation of live attenuated influenza viruses, which elicited robust humoral, mucosal, and cellular immunity against diverse virus strains.
Jeffrey V. Ravetch, Stylianos Bournazos
openaire +3 more sources
LC16m8: An attenuated smallpox vaccine
Vaccine, 2006 The frequency of moderate to severe adverse reactions associated with smallpox vaccines currently stockpiled in the US, and the continued threat of bioterrorism have prompted the development of effective vaccines with improved safety profiles. LC16m8, an attenuated, replicating smallpox vaccine derived from the Lister strain of vaccinia, is currently ...
Marc Gurwith +4 more
openaire +3 more sources
Directed attenuation to enhance vaccine immunity
PLOS Computational Biology, 2021 Many viral infections can be prevented by immunizing with live, attenuated vaccines. Early methods of attenuation were hit-and-miss, now much improved by genetic engineering. However, even current methods operate on the principle of genetic harm, reducing the virus’s ability to grow.
Rustom Antia, Hasan Ahmed, James J. Bull
openaire +5 more sources
Live attenuated intranasal influenza vaccine [PDF]
Human Vaccines & Immunotherapeutics, 2012 Annual vaccination is the most effective means of preventing and controlling influenza epidemics, and the traditional trivalent inactivated vaccine (TIV) is by far the most widely used. Unfortunately, it has a number of limitations, the most important of which is its poor immunogenicity in younger children and the elderly, the populations at greatest ...
Esposito, Susanna Maria Roberta +5 more
openaire +6 more sources
Live Attenuated Varicella Vaccine
The Journal of Pediatrics, 1985 Live attenuated varicella vaccine will in all probability soon be licensed in the United States for immunization of healthy children and adults and certain immunocompromised children. This vaccine can be expected to protect susceptibles from varicella (or to modify it) in those subsequently exposed to the wild virus.
openaire +12 more sources
Combination attenuation offers strategy for live-attenuated coronavirus vaccines [PDF]
Journal of Virology, 2018 AbstractWith an ongoing threat posed by circulating zoonotic strains, new strategies are required to prepare for the next emergent coronavirus (CoV). Previously, groups had targeted conserved coronavirus proteins as a strategy to generate live-attenuated vaccine strains against current and future CoVs.
Ralph S. Baric +10 more
openaire +4 more sources
Genetically attenuated malaria parasites as vaccines [PDF]
Expert Review of Vaccines, 2017 Despite the significant gains made with control efforts, malaria continues to be a dominant infectious disease threat in many parts of the world [1].
Stefan H. I. Kappe, Ashley M. Vaughan
openaire +4 more sources
Live attenuated vaccines for tuberculosis [PDF]
The Biochemist, 2021 Tuberculosis (TB) is a leading cause of infectious death worldwide. TB is caused by the bacterium Mycobacterium tuberculosis (Mtb) and transmission happens via inhalation of droplets and aerosols coughed by an individual with active disease. There are about 10 million cases of active TB annually, and it is estimated that approximately 2 billion people ...
openaire +3 more sources