Results 121 to 130 of about 123,822 (310)

Synthetic biology-inspired development of live attenuated influenza vaccines

npj Vaccines
Live attenuated influenza vaccines (LAIVs) provide robust, cross-protective immunity but have traditionally been developed empirically and are associated with safety concerns.
Qisi Zhang, Jiahui Cheng, Jihuan Hou, Yinlei Su, Le Li, Le Tong, Jing Li, Quan Shen, Zihao Wang, Minqi Wu, Zhen Li, Qikai Wang, Yunfei Zhang, Rui Sun, Longlong Si   +14 more
doaj   +1 more source

Histo-blood group antigens as receptors for rotavirus, new understanding on rotavirus epidemiology and vaccine strategyRotavirus host receptor and vaccine strategy

Emerging Microbes and Infections, 2017
The success of the two rotavirus (RV) vaccines (Rotarix and RotaTeq) in many countries endorses a live attenuated vaccine approach against RVs. However, the lower efficacies of both vaccines in many low- and middle-income countries indicate a need to ...
Xi Jiang, Yang Liu, Ming Tan
doaj   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Development and Application of Attenuated Plant Viruses as Biological Control Agents in Japan

Viruses
In 1929, it was reported that yellowing symptoms caused by a tobacco mosaic virus (TMV) yellow mosaic isolate were suppressed in tobacco plants that were systemically infected with a TMV light green isolate.
Yasuhiro Tomitaka, Yoshifumi Shimomoto, Bo-Song Ryang, Kazusa Hayashi, Tomoka Oki, Momoko Matsuyama, Ken-Taro Sekine   +6 more
doaj   +1 more source

A gorilla adenovirus-based vaccine against Zika virus induces durable immunity and confers protection in pregnancy [PDF]

, 2019
The teratogenic potential of Zika virus (ZIKV) has made the development of an effective vaccine a global health priority. Here, we generate two gorilla adenovirus-based ZIKV vaccines that encode for pre-membrane (prM) and envelope (E) proteins (GAd-Zvp ...
Brough, Douglas E, Curiel, David T, Diamond, Michael S, Dmitriev, Igor P, Fremont, Daved H, Hassan, Ahmed O, Kashentseva, Elena A, Zhao, Haiyan   +7 more
core   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Synthetic O‐Polysaccharide Backbone Units for a Single Antigen Vaccine Against Two Major Non‐Typhoidal Salmonella Serovars

Angewandte Chemie, EarlyView.
A modular strategy was developed to synthesize tri‐, hexa‐, and nona‐saccharides representing repeating units of the conserved O‐polysaccharide backbone of Salmonella. Conjugates of these glycans to bacteriophage Qβ induced strong IgG responses in mice and rabbits. Antibodies elicited recognized native O‐polysaccharides and conferred protection against
Xingling Pan, Changxin Huo, Soham Maity, Herbert Kavunja, Rachel Moszyk, Cameron Talbot, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +2 more sources

Research Progress on Varicella-Zoster Virus Vaccines

Vaccines
Varicella-zoster virus (VZV) poses significant public health challenges as the etiological agent of varicella (chickenpox) and herpes zoster (HZ), given its high transmissibility and potential for severe complications.
Hongjing Liu, Lingyan Cui, Sibo Zhang, Hong Wang, Wenhui Xue, Hai Li, Yuyun Zhang, Lin Chen, Ying Gu, Tingting Li, Ningshao Xia, Shaowei Li   +11 more
doaj   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Recombinant Listeria promotes tumor rejection by CD8+ T cell-dependent remodeling of the tumor microenvironment. [PDF]

, 2018
Agents that remodel the tumor microenvironment (TME), prime functional tumor-specific T cells, and block inhibitory signaling pathways are essential components of effective immunotherapy.
Barajas, Gonzalo, Deng, Weiwen, Desbien, Anthony L, Dubensky, Thomas W, Flores, Ruben, Hanson, William G, Hudson, Thomas E, Katibah, George E, Lauer, Peter, Lemmens, Edward E, Leong, Meredith L, Lira, Victor, Portnoy, Daniel A   +12 more
core   +1 more source