Results 51 to 60 of about 82,320 (302)

Solid‐State Nanopore Characterization of Dendrimer‐Peptide Conjugates Across Defined Peptide Loadings

Advanced Materials Interfaces, EarlyView.
Solid‐state nanopores are used to interrogate dendrimer‐peptide conjugates with systematically varied peptide loading. Single‐particle ionic current signatures reveal how ligand density modulates deformability, transport pathways, and electromechanical coupling during translocation.
Chaoming Gu, Jin Woong Lee, Kamruzzaman Joty, Marisela Leon, Santosh Khatri, Janeesha Manawasinghe, Seungpyo Hong, Min Jun Kim   +7 more
wiley   +1 more source

Elegant and Innovative Recoding Strategies for Advancing Vaccine Development

Vaccines
Recoding strategies have emerged as a promising approach for developing safer and more effective vaccines by altering the genetic structure of microorganisms, such as viruses, without changing their proteins.
François Meurens, Fanny Renois, Uladzimir Karniychuk   +2 more
doaj   +1 more source

A live attenuated varicella vaccine

Uirusu, 2009
The vaccine virus was isolated from a vesicle of a 3-year-old otherwise healthy boy called Oka (his family name) who had typical varicella. This virus was passaged through human embryonic lung cells, guinea pig embryonic cells at a low temperature, and human diploid cells (WI-38). It was then adapted to MRC-5 human diploid cells for vaccine preparation.
openaire   +3 more sources

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Live-attenuated vaccination in patients with inflammatory bowel disease while continuing or after elective switch to vedolizumab [PDF]

Intestinal Research
Background/Aims Vedolizumab (VDZ) is a gut-selective agent with a favorable safety profile. We aimed to assess the feasibility of elective switch from other advanced therapies to VDZ and subsequent live-attenuated vaccination while continuing VDZ in ...
Hisashi Shiga, Hiroshi Nagai, Yusuke Shimoyama, Takeo Naito, Rintaro Moroi, Yoichi Kakuta, Yoshitaka Kinouchi, Atsushi Masamune   +7 more
doaj   +1 more source

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

Attenuated influenza A viruses with modified cleavage sites in hemagglutinin as live vaccines

, 2008
Influenza A viruses are a public-health concern as they cause annual epidemics and may initiate a pandemic. Common inactivated influenza A vaccines induce a serum antibody response, which may not be protective against virus variation in the field.
Stech, Jürgen
core   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Coronavirus non-structural protein 1 is a major pathogenicity factor : implications for the rational design of coronavirus vaccines

, 2007
Zust, Roland Cervantes-Barragan, Luisa Kuri, Thomas Blakqori, Gjon Weber, Friedemann Ludewig, Burkhard Thiel, Volker 5 R21 AI062246/AI/United States NIAID Research Support, N.I.H., Extramural Research Support, Non-U.S.
Thiel Volker, Friedemann Weber, Cervantes-Barragan, L., Kuri, Thomas, Roland Züst, Kuri Thomas, Weber, Friedemann, Weber, F., Volker Thiel, Luisa Cervantes-Barragán, Kuri, T., Zust, R., Ludewig, Burkhard, Blakqori, Gjon, Gjon Blakqori, Ludewig Burkhard, Burkhard Ludewig, Cervantes-Barragán, Luisa, Weber Friedemann, Thiel, Volker, Thomas Kuri, Ludewig, B., Thiel, V., Züst, Roland, Blakqori Gjon, Züst Roland, Cervantes-Barragán Luisa   +26 more
core   +1 more source

New drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections [PDF]

, 2008
Tuberculosis remains the most common cause of death due to a single infective organism. Despite the availability of a vaccine and chemotherapeutic options, the global disease burden remains relatively unaffected.
Willcox, Benjamin, Gurdyal S Besra, Bhatt, Apoorva; id_orcid, Dover, LG, Apoorva Bhatt, Dover, Lynn, Besra, Gurdyal; id_orcid, Besra, Gurdyal, Bhatt, Apoorva, Lynn G Dover, Bhowruth, Veemal, Veemal Bhowruth, Benjamin E Willcox   +12 more
core   +1 more source