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On the mechanisms of conjugate vaccines [PDF]
Proceedings of the National Academy of Sciences, 2018 During the last three decades, the development and commercialization of conjugate vaccines against Haemophilus influenzae type b (Hib), pneumococcus, and serogroups C, A, W, and Y of meningococcus contributed to the virtual elimination of bacterial ...
R. Rappuoli +2 more
semanticscholar +4 more sources
Exploring the variables influencing the immune response of traditional and innovative glycoconjugate vaccines [PDF]
Frontiers in Molecular Biosciences, 2023 Vaccines are cost-effective tools for reducing morbidity and mortality caused by infectious diseases. The rapid evolution of pneumococcal conjugate vaccines, the introduction of tetravalent meningococcal conjugate vaccines, mass vaccination campaigns in ...
Francesca Micoli +4 more
doaj +3 more sources
Carbohydrate—protein conjugate vaccines [PDF]
Clinical Microbiology and Infection, 2003 Various pathogenic bacteria have coats of polysaccharide, many with repeating epitopes. Though polysaccharide vaccines have been available for some time, they induce mainly IgM production, and are only moderately protective in adults and ineffective in ...
Ada, G., Isaacs, D.
core +6 more sources
Vaccines against Meningococcal Diseases
Microorganisms, 2020 Neisseria meningitidis is the main cause of meningitis and sepsis, potentially life-threatening conditions. Thanks to advancements in vaccine development, vaccines are now available for five out of six meningococcal disease-causing serogroups (A, B, C, W,
Mariagrazia Pizza +2 more
doaj +2 more sources
Interactions of conjugate vaccines and co-administered vaccines [PDF]
Human Vaccines & Immunotherapeutics, 2016 Conjugate vaccines play an important role in the prevention of infectious diseases such as those caused by the bacteria Haemophilus influenzae (Hi) type b (Hib), Neisseria meningitidis, and Streptococcus pneumoniae. Vaccines developed against these 3 pathogens utilize 3 main carrier proteins, non-toxic mutant of diphtheria toxin (CRM197), diphtheria ...
H. Findlow, R. Borrow
semanticscholar +4 more sources
Genetic diversity of Streptococcus pneumoniae causing meningitis and sepsis in Singapore during the first year of PCV7 implementation [PDF]
Emerging Microbes and Infections, 2014 Streptococcus pneumoniae is a major cause of sepsis, meningitis and respiratory disease worldwide. Pneumococcal conjugate vaccines (PCVs) have now been implemented in many countries worldwide, including Singapore.
Elita Jauneikaite +5 more
doaj +4 more sources
Evaluation of the Induction of Immune Memory following Infant Immunisation with Serogroup C Neisseria meningitidis Conjugate Vaccines - Exploratory Analyses within a Randomised Controlled Trial [PDF]
, 2014 Aim: We measured meningococcal serogroup C (MenC)-specific memory B-cell responses in infants by Enzyme-Linked Immunospot (ELISpot) following different MenC conjugate vaccine schedules to investigate the impact of priming on immune memory.
Birks, Jacqueline +7 more
core +23 more sources
Strengths and weaknesses of pneumococcal conjugate vaccines
Glycoconjugate Journal, 2023 Multivalent vaccines addressing an increasing number of Streptococcus pneumoniae types (7-, 10-, 13-, 15-, 20-valent) have been licensed over the last 22 years.
F. Micoli +4 more
semanticscholar +1 more source
ACS Infectious Diseases, 2023 The surface of cells is coated with a dense layer of glycans, known as the cell glycocalyx. The complex glycans in the glycocalyx are involved in various biological events, such as bacterial pathogenesis, protection of bacteria from environmental ...
Rajendra S Rohokale, Zhongwu Guo
semanticscholar +1 more source