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On the mechanisms of conjugate vaccines [PDF]
Proceedings of the National Academy of Sciences, 2018 During the last three decades, the development and commercialization of conjugate vaccines against Haemophilus influenzae type b (Hib), pneumococcus, and serogroups C, A, W, and Y of meningococcus contributed to the virtual elimination of bacterial ...
R. Rappuoli +2 more
semanticscholar +4 more sources
SARS-CoV-2 Receptor Binding Domain (RBD) Protein–Protein Conjugate Induces Similar or Better Antibody Responses as Spike mRNA in Rhesus Macaques [PDF]
VaccinesBackground/Objectives: Rapid development of vaccines against SARS-CoV-2 was pivotal to controlling the COVID-19 pandemic. The emergency also provided a rare opportunity to test novel vaccine platforms such as mRNA in large clinical trials.
Puthupparampil V. Scaria +19 more
doaj +2 more sources
Vaccines against Meningococcal Diseases
Microorganisms, 2020 Neisseria meningitidis is the main cause of meningitis and sepsis, potentially life-threatening conditions. Thanks to advancements in vaccine development, vaccines are now available for five out of six meningococcal disease-causing serogroups (A, B, C, W,
Mariagrazia Pizza +2 more
doaj +2 more sources
Interactions of conjugate vaccines and co-administered vaccines [PDF]
Human Vaccines & Immunotherapeutics, 2016 Conjugate vaccines play an important role in the prevention of infectious diseases such as those caused by the bacteria Haemophilus influenzae (Hi) type b (Hib), Neisseria meningitidis, and Streptococcus pneumoniae. Vaccines developed against these 3 pathogens utilize 3 main carrier proteins, non-toxic mutant of diphtheria toxin (CRM197), diphtheria ...
H. Findlow, R. Borrow
semanticscholar +4 more sources
Strengths and weaknesses of pneumococcal conjugate vaccines
Glycoconjugate Journal, 2023 Multivalent vaccines addressing an increasing number of Streptococcus pneumoniae types (7-, 10-, 13-, 15-, 20-valent) have been licensed over the last 22 years.
F. Micoli +4 more
semanticscholar +1 more source
ACS Infectious Diseases, 2023 The surface of cells is coated with a dense layer of glycans, known as the cell glycocalyx. The complex glycans in the glycocalyx are involved in various biological events, such as bacterial pathogenesis, protection of bacteria from environmental ...
Rajendra S Rohokale, Zhongwu Guo
semanticscholar +1 more source
On-demand biomanufacturing of protective conjugate vaccines
Science Advances, 2021 In vitro conjugate vaccine expression technology enables rapid and portable biosynthesis of protective antibacterial vaccines. Conjugate vaccines are among the most effective methods for preventing bacterial infections.
Jessica C. Stark +12 more
semanticscholar +1 more source
Frontiers in Molecular Biosciences, 2023 Vaccines are cost-effective tools for reducing morbidity and mortality caused by infectious diseases. The rapid evolution of pneumococcal conjugate vaccines, the introduction of tetravalent meningococcal conjugate vaccines, mass vaccination campaigns in ...
Francesca Micoli +4 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2021 The universal administration of pneumococcal conjugate vaccines (PCVs) had been demonstrated as an effective way to prevent Streptococcus pneumoniae infection.
Qian-qian Du, W. Shi, Dan Yu, K. Yao
semanticscholar +1 more source
Clinical Infectious Diseases, 2020 Background The epidemiology of acute bacterial meningitis has changed substantially since the introduction of conjugate vaccines. Methods We analyzed nationwide surveillance data of all cerebrospinal fluid isolates received by the Netherlands Reference ...
D. Koelman +5 more
semanticscholar +1 more source