Results 31 to 40 of about 1,085,685 (349)

Typhoid Fever Surveillance, Incidence Estimates, and Progress Toward Typhoid Conjugate Vaccine Introduction — Worldwide, 2018–2022

MMWR. Morbidity and mortality weekly report, 2023
Typhoid fever, an acute febrile illness caused by Salmonella enterica serovar Typhi (S. Typhi), is endemic in many low- and middle-income countries† (1).
Molly Hancuh, J. Walldorf, Anna A. Minta, C. Tévi-Bénissan, K. Christian, Yoann Nedelec, K. Heitzinger, M. Mikoleit, A. Tiffany, A. Bentsi-Enchill, L. Breakwell   +10 more
semanticscholar   +1 more source

Promising directions for vaccine development to prevent shigellosis

Биопрепараты: Профилактика, диагностика, лечение, 2022
Shigellosis (bacterial dysentery) is an acute infectious disease caused by Shigella spp., members of the Enterobacteriaceae family. The disease has the highest mortality rate amongst bacterial enteric infections.
M. V. Abramtseva, E. O. Nemanova, N. S. Alekhina   +2 more
doaj   +1 more source

On the mechanisms of conjugate vaccines

Proceedings of the National Academy of Sciences of the United States of America, 2018
During the last three decades, the development and commercialization of conjugate vaccines against Haemophilus influenzae type b (Hib), pneumococcus, and serogroups C, A, W, and Y of meningococcus contributed to the virtual elimination of bacterial ...
R. Rappuoli, E. De Gregorio, P. Costantino   +2 more
semanticscholar   +1 more source

ANTIGENIC ACTIVITY ASSAYS OF EXPERIMENTAL CONJUGATE VACCINES BASED ON SYNTHETIC OLIGOSACCHARIDE LIGANDS AND CRM197 CARRIER PROTEIN

Медицинская иммунология, 2017
So far, there is no effective treatment for a number of socially significant bacterial and fungal diseases. β-(1→3) glucans are polysaccharides consisting of glucose units linked together with β-(1→3)- glycoside bonds.
E. G. Bogomolova, O. A. Dodrovolskaya, E. A. Fedorova, A. M. Kondrashkina, N. N. Kolmakov, S. A. Ishchuk, I. V. Dukhovlinov, A. S. Simbirtsev   +7 more
doaj   +1 more source

A review of complement sources used in serum bactericidal assays for evaluating immune responses to meningococcal ACWY conjugate vaccines

Human Vaccines & Immunotherapeutics, 2019
Invasive meningococcal disease is rare and potentially devastating but often vaccine-preventable. Evaluation of meningococcal vaccine effectiveness is impractical owing to relatively low disease incidence; protection is therefore estimated using serum ...
J. Findlow, P. Balmer, R. Borrow
semanticscholar   +1 more source

Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques

npj Vaccines, 2023
An effective HIV-1 vaccine remains a critical unmet need for ending the AIDS epidemic. Vaccine trials conducted to date have suggested the need to increase the durability and functionality of vaccine-elicited antibodies to improve efficacy.
Danielle Nettere, Shakthi Unnithan, Nicole Rodgers, Junsuke Nohara, Paul Cray, Madison Berry, Caroline Jones, Lawrence Armand, Shuk Hang Li, Stella J. Berendam, Genevieve G. Fouda, Derek W. Cain, Taylor N. Spence, Joshua A. Granek, Clemontina A. Davenport, Robert J. Edwards, Kevin Wiehe, Koen K. A. Van Rompay, M. Anthony Moody, Sallie R. Permar, Justin Pollara   +20 more
doaj   +1 more source

Relationship between immune response to pneumococcal conjugate vaccines in infants and indirect protection after vaccine implementation

Expert Review of Vaccines, 2019
Introduction: Streptococcus pneumoniae is a leading cause of morbidity and mortality worldwide. Widespread infant vaccination with pneumococcal conjugate vaccines (PCVs) substantially reduced vaccine-serotype pneumococcal disease by direct protection of ...
R. Dagan
semanticscholar   +1 more source

Effectiveness of pneumococcal conjugate vaccines against invasive pneumococcal disease among children under five years of age in Africa: A systematic review

PLoS ONE, 2019
Background Despite the widespread implementation of the pneumococcal conjugate vaccine, Streptococcus pneumoniae remains the leading cause of severe pneumonia associated with mortality among children less than 5 years of age worldwide, with the highest ...
J. Ngocho, Best Magoma, Gaudencia Alois Olomi, M. Mahande, S. Msuya, M. D. de Jonge, B. Mmbaga   +6 more
semanticscholar   +1 more source

ERA OF CONJUGATE VACCINES: INTERNATIONAL EXPERIENCE OF SUCCESSFUL APPLICATION

Педиатрическая фармакология, 2008
The article highlights comparative characteristics of the polysaccharide and conjugate vaccines against pneumococcal infection, meningococcosis and haemophilus influenza. The author stresses the advantage of the conjugate vaccines.
M.V. Fedoseenko, M.G. Galitskaya, L.S. Namazova   +2 more
doaj   +2 more sources

Discovery of Semi- and Fully-Synthetic Carbohydrate Vaccines Against Bacterial Infections Using a Medicinal Chemistry Approach

Chemical Reviews, 2021
The glycocalyx, a thick layer of carbohydrates, surrounds the cell wall of most bacterial and parasitic pathogens. Recognition of these unique glycans by the human immune system results in destruction of the invaders.
P. Seeberger
semanticscholar   +1 more source