Results 31 to 40 of about 1,048,296 (327)

Progress toward the global control of Neisseria meningitidis: 21st century vaccines, current guidelines, and challenges for future vaccine development

Human Vaccines & Immunotherapeutics, 2018
The control of meningitis, meningococcemia and other infections caused by Neisseria meningitidis is a significant global health challenge. Substantial progress has occurred in the last twenty years in meningococcal vaccine development and global ...
A. W. Dretler, N. G. Rouphael, D. S. Stephens   +2 more
doaj   +1 more source

A Trial of a 7-Valent Pneumococcal Conjugate Vaccine in HIV-Infected Adults. [PDF]

, 2010
BACKGROUND: Streptococcus pneumoniae is a leading and serious coinfection in adults with human immunodeficiency virus (HIV) infection, particularly in Africa.
French, N, Gilks, CF, Gordon, SB, Longwe, H, Molyneux, ME, Mwafulirwa, G, Mwaiponya, M, Mwalukomo, T, White, SA, Zijlstra, EE   +9 more
core   +2 more sources

Extensively Drug-Resistant Typhoid - Are Conjugate Vaccines Arriving Just in Time?

New England Journal of Medicine, 2018
Extensively Drug-Resistant Typhoid More than 1000 cases of XDR Salmonella Typhi have been confirmed in Pakistan. Until recently, vaccines against typhoid have had limited efficacy and durability of immunogenicity, but an effective conjugate vaccine is ...
J. Andrews, F. Qamar, R. Charles, E. Ryan   +3 more
semanticscholar   +1 more source

Effectiveness of pneumococcal conjugate vaccines against invasive pneumococcal disease among children under five years of age in Africa: A systematic review

PLoS ONE, 2019
Background Despite the widespread implementation of the pneumococcal conjugate vaccine, Streptococcus pneumoniae remains the leading cause of severe pneumonia associated with mortality among children less than 5 years of age worldwide, with the highest ...
J. Ngocho, Best Magoma, Gaudencia Alois Olomi, M. Mahande, S. Msuya, M. D. de Jonge, B. Mmbaga   +6 more
semanticscholar   +1 more source

ANTIGENIC ACTIVITY ASSAYS OF EXPERIMENTAL CONJUGATE VACCINES BASED ON SYNTHETIC OLIGOSACCHARIDE LIGANDS AND CRM197 CARRIER PROTEIN

Медицинская иммунология, 2017
So far, there is no effective treatment for a number of socially significant bacterial and fungal diseases. β-(1→3) glucans are polysaccharides consisting of glucose units linked together with β-(1→3)- glycoside bonds.
E. G. Bogomolova, O. A. Dodrovolskaya, E. A. Fedorova, A. M. Kondrashkina, N. N. Kolmakov, S. A. Ishchuk, I. V. Dukhovlinov, A. S. Simbirtsev   +7 more
doaj   +1 more source

Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques

npj Vaccines, 2023
An effective HIV-1 vaccine remains a critical unmet need for ending the AIDS epidemic. Vaccine trials conducted to date have suggested the need to increase the durability and functionality of vaccine-elicited antibodies to improve efficacy.
Danielle Nettere, Shakthi Unnithan, Nicole Rodgers, Junsuke Nohara, Paul Cray, Madison Berry, Caroline Jones, Lawrence Armand, Shuk Hang Li, Stella J. Berendam, Genevieve G. Fouda, Derek W. Cain, Taylor N. Spence, Joshua A. Granek, Clemontina A. Davenport, Robert J. Edwards, Kevin Wiehe, Koen K. A. Van Rompay, M. Anthony Moody, Sallie R. Permar, Justin Pollara   +20 more
doaj   +1 more source

Comparison of Strategies and Incidence Thresholds for Vi Conjugate Vaccines Against Typhoid Fever: A Cost-effectiveness Modeling Study

Journal of Infectious Diseases, 2018
Background Typhoid fever remains a major public health problem globally. While new Vi conjugate vaccines hold promise for averting disease, the optimal programmatic delivery remains unclear.
N. Lo, Ribhav Gupta, J. Stanaway, D. Garrett, I. Bogoch, S. Luby, J. Andrews   +6 more
semanticscholar   +1 more source

Setting priorities for development of emerging interventions against childhood pneumonia, meningitis and influenza [PDF]

, 2012
WAcute lower respiratory infections, which broadly include pneumonia and bronchiolitis, are still the leading cause of childhood mortality. ALRI contributed to 18% of all deaths in children younger than five years of age in 2008, and the main pathogens ...
Black, Catto, Choudhuri, George, Graham, Higginson, Horwood, Huda, Lawn, Nair, Nair, Nair, O'Brien, Osterholt, Rudan, Rudan, Rudan, Rudan, Rudan, Tomlinson, Watt, Webster   +21 more
core   +2 more sources

Design and production of conjugate vaccines against S. Paratyphi A using an O-linked glycosylation system in vivo

npj Vaccines, 2018
Enteric fever, mainly caused by Salmonella enterica serovar Paratyphi A, remains a common and serious infectious disease worldwide. As yet, there are no licensed vaccines against S. Paratyphi A.
Peng Sun, Chao Pan, Ming Zeng, Bo Liu, Haoyu Liang, Dongshu Wang, Xiankai Liu, Bin Wang, Yufei Lyu, Jun Wu, Li Zhu, Hengliang Wang   +11 more
semanticscholar   +1 more source

Indirect effect of 7-valent and 13-valent pneumococcal conjugated vaccines on pneumococcal pneumonia hospitalizations in elderly [PDF]

, 2018
Background: Pneumonia is one of the leading causes of mortality and has a high burden in morbidity. In Portugal, 7-valent pneumococcal conjugated vaccine (PCV) was used since 2001 and PCV10/13 since 2009, being the last introduced into the National ...
Froes, Filipe, Gonçalves, Paulo, Gómez, Verónica, Kislaya, Irina, Nunes, Baltazar, Rodrigues, Ana Paula, Sousa-Uva, Mafalda   +6 more
core   +2 more sources