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Advances in Oral Subunit Vaccine Design [PDF]

Vaccines, 2020
Many pathogens invade the host at the intestinal surface. To protect against these enteropathogens, the induction of intestinal secretory IgA (SIgA) responses is paramount. While systemic vaccination provides strong systemic immune responses, oral vaccination is the most efficient way to trigger protective SIgA responses.
Hans Van der Weken, Eric Cox, Bert Devriendt   +2 more
openaire   +6 more sources

An Established Th2-Oriented Response to an Alum-Adjuvanted SARS-CoV-2 Subunit Vaccine Is Not Reversible by Sequential Immunization with Nucleic Acid-Adjuvanted Th1-Oriented Subunit Vaccines

Vaccines, 2021
A recently reported parallel preclinical study between a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine and an inactivated SARS-CoV-2 vaccine adjuvanted with alum showed pulmonary immunopathology typical of eosinophil ...
Han Cao, Shengran Yang, Yunfei Wang, Ning Luan, Xingxiao Yin, Kangyang Lin, Cunbao Liu   +6 more
doaj   +2 more sources

Advances in protein subunit vaccines against H1N1/09 influenza [PDF]

Frontiers in Immunology
The A/H1N1pdm09 influenza virus, which caused the 2009 pandemic, has since become a recurring strain in seasonal influenza outbreaks. Given the ongoing threat of influenza, protein subunit vaccines have garnered significant attention for their safety and
Yu Zhang, Yu Zhang, Jingyao Gao, Wenqi Xu, Xingyu Huo, Jingyan Wang, Yirui Xu, Wenting Ding, Zeliang Guo, Rongzeng Liu   +9 more
doaj   +2 more sources

Subunit Vaccines Against Emerging Pathogenic Human Coronaviruses

Frontiers in Microbiology, 2020
Seven coronaviruses (CoVs) have been isolated from humans so far. Among them, three emerging pathogenic CoVs, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and a newly ...
Ning Wang, Jian Shang, Shibo Jiang, Shibo Jiang, Lanying Du   +4 more
doaj   +2 more sources

Research Progress on Varicella-Zoster Virus Vaccines

Vaccines
Varicella-zoster virus (VZV) poses significant public health challenges as the etiological agent of varicella (chickenpox) and herpes zoster (HZ), given its high transmissibility and potential for severe complications.
Hongjing Liu, Lingyan Cui, Sibo Zhang, Hong Wang, Wenhui Xue, Hai Li, Yuyun Zhang, Lin Chen, Ying Gu, Tingting Li, Ningshao Xia, Shaowei Li   +11 more
doaj   +2 more sources

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age-Related Declines in Humoral and Cellular Immunity Relative to Shingrix. [PDF]

Adv Sci (Weinh)
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Song YE, Yan J, Ou BS, Saouaf OM, Eckman N, Appel EA.   +5 more
europepmc   +2 more sources

Adjuvant Selection for Influenza and RSV Prefusion Subunit Vaccines [PDF]

, 2021
Subunit vaccines exhibit favorable safety and immunogenicity profiles and can be designed to mimic native antigen structures. However, pairing with an appropriate adjuvant is imperative in order to elicit effective humoral and cellular immune responses ...
Naphak Modhiran, Chappell, K.J., Danushka K. Wijesundara, Christopher L. D. McMillan, Young, P.R., Watterson, D., Paul R. Young, Li, Z., Isaacs, A., Modhiran, N., Zheyi Li, Daniel Watterson, Stacey T. M. Cheung, Charani Ranasinghe, Ranasinghe, C., Ariel Isaacs, McMillan, C.L.D., Keith J. Chappell, Cheung, S.T.M., Wijesundara, D.K.   +19 more
core   +1 more source

Adjuvants : an essential component of neisseria vaccines [PDF]

, 2009
Adjuvants may be classified into delivery systems and immune potentiator or modulator molecules based on their mechanism of action. Neisseria vaccines containing traditional adjuvants such as aluminium salts have existed for long time, but meningitis ...
Acevedo, R., del Campo, J., Zayas, C., Cuello, M., Romeu, B., Ferro, Valerie A., Gonzales, E., Cabrera, O., Balbao, J.   +8 more
core   +4 more sources

A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin

Nature Communications, 2021
Tuberculosis (TB) subunit vaccines have been investigated as boosters for BCG-induced immunity. Here, the authors design a TB subunit vaccine that doesn't share antigens with BCG and show that co-administration of the two vaccines broadens the T cell ...
Joshua S. Woodworth, Helena Strand Clemmensen, Hannah Battey, Karin Dijkman, Thomas Lindenstrøm, Raquel Salvador Laureano, Randy Taplitz, Jeffrey Morgan, Claus Aagaard, Ida Rosenkrands, Cecilia S. Lindestam Arlehamn, Peter Andersen, Rasmus Mortensen   +12 more
doaj   +1 more source

RABIES SUBUNIT VACCINES

Journal of General Virology, 1983
Conclusions The secondary and tertiary structures of the rabies virus spike G protein are important for its ability to induce VN antibodies and confer immunity to the host. For a subunit peptide vaccine to be as effective as the native spike G protein, it would appear that the amino acid sequence comprising the antigenic determinant for VN antibody ...
W H, Wunner, B, Dietzschold, P J, Curtis, T J, Wiktor   +3 more
openaire   +2 more sources