Results 231 to 240 of about 471,639 (303)

MT‐RNR1 genotype testing for preventing aminoglycoside‐mediated ototoxicity: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3002-3011, September 2026.
Aminoglycosides are broad‐spectrum antibiotics used in the management of severe infections. Aminoglycosides are associated with nephrotoxicity and ototoxicity. Although dosing strategies such as once‐daily administration and therapeutic drug monitoring have reduced the incidence of nephrotoxicity, ototoxicity remains unpredictable and may occur at ...
John H. McDermott, Sian Hilton, Cinzia Dello Russo, Nicola Booth, Simon Drysdale, Philip Howard, Stephen Hughes, Mallinath Chakraborty, Helen McDevitt, Charlotte Alston, Maya Desai, Mike Beadsworth, Adam Reynolds, Serim Min, Katherine Payne, Munir Pirmohamed, William G. Newman   +16 more
wiley   +1 more source

Nanomaterial-based vaccines: An advanced approach against rotavirus: A review article. [PDF]

Hum Vaccin Immunother
Soroush Fard A, Kalantar K, Teimoori A, Barati M, Arezumand R, Fani M.   +5 more
europepmc   +1 more source

Nucleases and Their Inhibitors: Exploring Biological Roles, Industrial Applications, and Challenges in Heterologous Expression

Biotechnology Journal, Volume 21, Issue 9, September 2026.
Graphical Abstract and Lay Summary Intracellular nucleases, depicted as blue circles in a nucleosome, hydrolyze phosphodiester bonds, repair damaged DNA using DNA base excision repair (BER), mismatch repair (MMR), and homologous recombination (HR), and are involved in DNA replication.
Wian Vermeulen, Anton Du Preez van Staden, Leon M. T. Dicks   +2 more
wiley   +1 more source

Development of a potential vaccine against dengue and chikungunya virus co-infection using immunoinformatics and structural evaluation. [PDF]

J Genet Eng Biotechnol
Ullah S, Xie J, Guo C, Khan H, Zou X, Lai T, Shah A, Islam R, Luo J, Xu W, Jan AU, Khan A, Xiao J, He F, Li L.   +14 more
europepmc   +1 more source

Spatial Omics in High‐Grade Gliomas: Mapping Immune–Tumor Niches for Precision Therapy

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT High‐grade gliomas (HGGs), particularly glioblastoma (GBM), remain among the most lethal human cancers despite decades of molecular profiling and therapeutic innovation. A primary reason for treatment failure is that HGG biology is spatial: malignant cell states, immune suppression, metabolic stress, and therapeutic resistance are organized ...
Saniyah Shaikh, Thaabit Raziq, Sulaf B. Alfares, Touleen T. Raslan, Ismail A. Abdullah, Itika Arora, Shamsa Saleh, Mohammed Imran Khan, Ahmed Yaqinuddin   +8 more
wiley   +1 more source

Pre-Clinical Development of Two DNA Vaccines Encoding MrkA of Klebsiella pneumoniae: Effect of Plasmid Backbone on Immunogenicity and Protective Efficacy Against Sepsis. [PDF]

Microb Biotechnol
Vicente-Pazos M, García-Ríos E, Quílez-Agraz L, Ustrell-Sallent G, Pérez-Romero P, López-Siles M, McConnell MJ.   +6 more
europepmc   +1 more source

Qianjinweijingtang Decoction and Its Granule Inhibit Respiratory Syncytial Virus Infection and the Associated Inflammatory Response

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The classical herbal formula Qianjinweijingtang in both decoction and granule forms, exhibits anti‐RSV activity. Isoliquiritigenin, quercetin, and gallic acid are identified as key active compounds. The mechanism involves interfering with viral entry and downregulating HIF‐1α and inflammatory responses, positioning the granule formulation as a ...
Chu‐Yi Liao, Mei‐Lan Yang, Ze‐Ping Chen, Bin Chen, Yu‐Jun Tang, Zhen Wang, Hui‐Nan Zhao, Su‐Hua Deng, Jin‐Hai Ye, Zhong Liu, Li‐Feng Chen, Man‐Mei Li   +11 more
wiley   +1 more source

Recent advances in Epstein-Barr virus vaccines development from mechanistic exploration to clinical translation. [PDF]

NPJ Vaccines
Hong L, Zhou J, Tan J, Zhu X, Chen W, Xie S, Huang B, Chen K.   +7 more
europepmc   +1 more source

Global disparities in COVID-19 vaccine coverage associated with trajectories of SARS-CoV-2 adaptation. [PDF]

BMC Infect Dis
Yang L, Zhou Z, Lin Q, Chen Y, Sun Y, Wang Z.   +5 more
europepmc   +1 more source

Twenty-five years of human metapneumovirus research. [PDF]

Clin Microbiol Rev
Mboup EB, Dubois J, Hamelin M-È, Rosa-Calatrava M, Boivin G.   +4 more
europepmc   +1 more source