Results 291 to 300 of about 1,877,160 (342)

Synthetic vehicles for DNA vaccination

Journal of Drug Targeting, 2009
DNA vaccination is an attractive immunization method able to induce robust cellular immune responses in pre-clinical models. However, clinical DNA vaccination trials performed thus far have resulted in marginal responses. Consequently, strategies are currently under development to improve the efficacy of DNA vaccines. A promising strategy is the use of
van den Berg, J.H., Nuijen, B., Schumacher, T.N., Haanen, J.B., Storm, G., Beijnen, J.H., Hennink, W.E.   +6 more
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From synthetic antigens to synthetic vaccines

Immunology Today, 1981
AbstractThe availability of synthetic antigens permitted a systematic elucidation of the molecular basis of antigenicity, as well as of other phenomena, and to establish the genetic control of immune response and its link to the major histocompatibility region of the species.
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SYNTHETIC PEPTIDE IMMUNOGENS AS VACCINES

Annual Review of Microbiology, 1983
Synthetic peptide immunogens have been shown to elicit antibodies that can react with full-length proteins containing that peptide. Such antibodies are directed against a specific region of the protein chosen in advance by the investigator and so have a predetermined specificity. In basic research, these antibodies are useful in identifying the protein
T M, Shinnick, J G, Sutcliffe, N, Green, R A, Lerner   +3 more
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Synthetic peptides as cancer vaccines

Peptide Science, 2002
AbstractEffective cancer therapy or prevention has been the dream of physicians and scientists for many years. Although we are still very far from our ultimate goal of cancer prevention, significant milestones have been realized in terms of our knowledge base and understanding of the pathogenesis of cancerous cells and the involvement of the immune ...
Roshni, Sundaram, Naveen K, Dakappagari, Pravin T P, Kaumaya   +2 more
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Synthetic peptide vaccines: success at last

Vaccine, 1995
Peptide vaccines would form the ideal ultimate vaccine because they are safe both in production as well as application, easy to handle, store and transport. Peptide vaccines have the advantage that they can be produced in a completely reproducible manner, they are cheap compared to subunit or whole protein vaccines and potentially they can be precisely
Meloen, R.H., Casal, J.I., DaIsgaard, K., Langeveld, J.P.M.   +3 more
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Synthetic Peptide Vaccines for Schistosomiasis

1995
Schistosomiasis is a chronic disease that infects an estimated 200 million persons, leading to an estimated 800,000 to 1 million annual deaths. It ranks second only to malaria in terms of morbidity and mortality caused by a parasitic disease. In addition, there is increasing evidence that schistosome infection may have profound effects on growth in ...
D A, Harn, S R, Reynolds, S, Chikunguwo, S, Furlong, C, Dahl   +4 more
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Synthetic immunomodulators and synthetic vaccines.

Critical reviews in therapeutic drug carrier systems, 1987
Efforts have been made for several years to obtain well-defined, nontoxic adjuvants and antigens which could be used for human vaccination and immunostimulation. Among synthetic adjuvants, MDP represents one of the most studied family of compounds. This molecule is the minimal active structure of whole Mycobacteria and has been shown to be endowed with
C, Leclerc, F R, Vogel
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Synthetic Vaccines — A Dream or Reality

1972
A great deal of information has been presented at this conference concerning vaccination and vaccines. This has included modification and improvement of known vaccine preparations or the route of vaccination; the possible use of virus subunits or purified virus proteins in vaccination; and the development of new vaccines with specificities different ...
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The Development of Synthetic Vaccines

Hospital Practice, 1981
R A, Lerner, N, Green, A, Olson, T, Shinnick, J G, Sutcliffe   +4 more
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Synthetic Antigens and Vaccines

1989
Early studies in our laboratory have demonstrated that synthetic antigens containing an immunoreactive region of a protein can give rise to a specific, and often conformation-dependent, immune response towards the intact native protein (Arnon et al, 1971). When the protein in question is a component of a virus e.g.
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