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Development of Synthetic Vaccines
1993The development of vaccines has been one of the most important achievements in immunology and medicine to date. It was initiated almost two hundred years ago, by the famous trial of Jenner, who inoculated a small boy with cow pox, thereby achieving preventive immunity against the fatal small pox, a process which eventually led to the eradication of ...
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Synthetic Vaccines for Infectious and Autoimmune Diseases
1996The ideal vaccine is one that is stable, safe, administered orally in a single dose at birth, 100% effective, reasonably priced, and protective for a lifetime. Unfortunately, there is no such vaccine (Dowdle and Orenstein, 1995). The development of vaccines has been one of the most important achievements in immunology and medicine.
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Protein Epitope Mimetics: From New Antibiotics to Supramolecular Synthetic Vaccines.
Accounts of Chemical Research, 2017Katja Zerbe, K. Moehle, John A. Robinson
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The Production and Characterization of Synthetic Glycoconjugate Vaccines
Chemical conjugation of polysaccharides to protein carriers has become essential in carbohydrate vaccine development to enhance the poor immunogenicity of glycans. Neutral and uncharged carbohydrates induce T-cell independent responses, failing to produce robust IgG antibodies or sustained T-cell memory and conjugating native or synthetic glycans with ...Aina, Valenti +2 more
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Peptides as Immunogens: Prospects for Synthetic Vaccines
1986The basis for the utilization of synthetic peptides as immunogens was laid during our early studies on the antigenicity of proteins. The initial findings that covalent attachment of tyrosine oligopeptides to gelatin by polymeric techniques resulted in augmentation of its immunogenicity (SELA and ARNON 1960) led us to the synthesis of both linear and ...
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Synthetic alternatives to Matrigel
Nature Reviews Materials, 2020Elizabeth A Aisenbrey, William L Murphy
exaly
Recent Developments in Synthetic Carbohydrate-Based Diagnostics, Vaccines, and Therapeutics.
Chemistry, 2015Alberto Fernández‐Tejada +2 more
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