Results 181 to 190 of about 31,151 (261)

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1685-1695, June 2026.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Current status on encephalitic alphavirus vaccines development: Advances, challenges, and global health perspectives. [PDF]

Infect Med (Beijing)
Yang X, Ning Y, Xu C, Zhang Q, Dong Y, Wang Y, Zhang F, Lei Y, Ye W.   +8 more
europepmc   +1 more source

Delivering Proteins and Enzymes to Solid Tumors Through the Development of Stimuli‐Responsive Nanocarriers

ChemNanoMat, Volume 12, Issue 6, June 2026.
Stimuli‐responsive strategies to achieve controlled release of protein‐based therapeutic agents into solid tumors. Proteins, enzymes, and peptides have long been recognized as valuable therapeutic agents, particularly in oncology. However, their complex chemical structures render them more sensitive than smaller chemotherapeutic drugs.
Guillermo Plaza‐Palomo, Diana Benita‐Donadios, Sandra Jiménez‐Falcao, Alejandro Baeza   +3 more
wiley   +1 more source

Engineering the ADDomer Nanoparticle Vaccine Scaffold for Improved Assembly and Enhanced Stability. [PDF]

ACS Synth Biol
Balchin G, Kabasakal BV, Strofaldi A, Hall S, Fletcher C, Buzas D, Bufton JC, Yadav SKN, Shen D, Garzoni F, Bunzel HA, McManus JJ, Schaffitzel C, Berger I.   +13 more
europepmc   +1 more source

Production and Purification of Mesenchymal Stem Cell‐Derived Extracellular Vesicles Using Preferential Exclusion Chromatography

ELECTROPHORESIS, Volume 47, Issue 6, Page 533-542, June 2026.
A scalable purification strategy using hydroxyl (OH) monolithic chromatography enables efficient isolation and direct concentration of MSC‐EVs from adherent and microcarrier‐based upstreams. This approach supports process scale‐up while ensuring high purity suitable for therapeutic EV manufacturing.
Katja Vrabec, Andrej Raspor, Darja Božič, Nastja Bizjak Ternik, Ana Železnik, Valentina Novak, Ivana Petrović Koshmak, Maja Leskovec, Aleš Štrancar   +8 more
wiley   +1 more source

Immunogenicity and Protection of mRNA Vaccine Encoding Spike Protein of SARS-CoV-2 Omicron-XEC Subvariant. [PDF]

Int J Mol Sci
Guan X, Cho H, Liu Q, Qian S, Du L.
europepmc   +1 more source

Downstream Purification Strategies for Virus-like Particles: A Systematic Review of Structure Preservation, Impurity Control, and Viral Safety. [PDF]

Microorganisms
Zhang J, Chen C.
europepmc   +1 more source

Nanoparticle vaccine formulations for dengue virus.

RSC Pharm
Murphy CT, Ainslie KM.
europepmc   +1 more source

A porcine circovirus type 2d-based virus-like particle subunit vaccine effectively protects pigs against homologous challenge. [PDF]

Front Microbiol
Chen P, Sun Y, Wang M, Li C, Xia Y, Liu H, Qi L, Si F, Miao D.   +8 more
europepmc   +1 more source

Why do we have a vaccine for measles, but not cytomegalovirus (CMV)? [PDF]

PLoS Pathog
Schleiss MR, Permar SR, Plotkin SA.
europepmc   +1 more source