Results 191 to 200 of about 59,754 (305)

Engineering the ADDomer Nanoparticle Vaccine Scaffold for Improved Assembly and Enhanced Stability. [PDF]

ACS Synth Biol
Balchin G, Kabasakal BV, Strofaldi A, Hall S, Fletcher C, Buzas D, Bufton JC, Yadav SKN, Shen D, Garzoni F, Bunzel HA, McManus JJ, Schaffitzel C, Berger I.   +13 more
europepmc   +1 more source

Structural insight into the assembly and D antigenicity of polio type 1 stabilized virus-like particles. [PDF]

NPJ Vaccines
Hong Q, Chen T, Han W, Wang S, Lian C, Zhang Y, Ruan L, Wang T, Lin C, Song C, Liu Q, Wang X, Cong Y, Huang Z.   +13 more
europepmc   +1 more source

A systematic review on vaccine developmental approaches: Evaluating efficacy, and addressing challenges of infectious diseases in the post-COVID-19 era. [PDF]

Virus Res
Sithole MN, Khan MR, Mohammed HA, Khan RA, Naik K, Choonara YE.   +5 more
europepmc   +1 more source

Preparing for the Next Potential Pandemic-Chikungunya, Dengue, Zika and Other Viruses. [PDF]

Viruses
Vajo Z, Laszlofy C.
europepmc   +1 more source

Media‐dependent performance of rabies virus‐like particle production under low oxygen tension in baculovirus‐infected Sf9 cells

Journal of Chemical Technology &Biotechnology, Volume 101, Issue 6, Page 1273-1282, June 2026.
Abstract BACKGROUND Rabies continues to pose a major public health threat, causing approximately 59 000 deaths each year, especially in regions with limited resources where high costs restrict vaccine access. Safer and scalable vaccine platforms, such as virus‐like particles, are promising alternatives, but their production is highly sensitive to ...
Júlia Públio Rabello, Milena Miyu Teruya, Fernanda Angela Correia Barrence, Thaissa Consoni Bernardino, Jaci Leme, Luis Giovani de Oliveira Guardalini, Noemi Nosomi Taniwaki, Soraia Attie Calil Jorge, Eutimio Gustavo Fernández Núñez   +8 more
wiley   +1 more source

Targeting Middle East Respiratory Syndrome Coronavirus Spike Fusion Machinery With Antiviral Peptides: In Silico Exploration of the Heptad Repeat 2 Domain

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Griffithsin, Brevinin‐2, and CCL20 were identified as potent MERS‐CoV fusion inhibitor candidates targeting the HR2 domain through integrated molecular docking, MD simulations, and MM/PBSA analyses. These peptides demonstrated superior binding stability and favorable safety profiles compared to the standard inhibitor, supporting their potential as ...
Nasser Alotaiq, Doni Dermawan, Samir Chtita   +2 more
wiley   +1 more source

Oropouche Virus (OROV) Vaccine Development for Vulnerable Populations: Epidemiological Context, Challenges and Future Directions. [PDF]

Vaccines (Basel)
Wu W, Kam YW.
europepmc   +1 more source

Investigating the role of a conserved hydrophobic pocket of gp41 in the anti‐HIV activity of fusion inhibitors

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Membrane fusion between HIV and host cells requires interaction between the N‐terminal and C‐terminal repeat regions (NHR and CHR) of the gp41 envelope subunit. A deep hydrophobic pocket (HP) on the surface of NHR is considered crucial in this interaction.
Daniel Polo‐Megías, Mario Cano‐Muñoz, Laura Sánchez‐Martínez, Sara Lestani, Christiane Moog, Thomas Decoville, María Carmen Salinas‐García, José Antonio Gavira, Ana Cámara‐Artigas, Francisco Conejero‐Lara   +9 more
wiley   +1 more source

A first-in-human Phase 1/1b randomized trial evaluating the safety and immunogenicity of a respiratory syncytial virus (RSV) virus-like particle subunit vaccine (IVX-121) in healthy young and older adults. [PDF]

Hum Vaccin Immunother
De Coster I, Leroux-Roels I, Withanage K, Suykens L, D'Onofrio V, Leroux-Roels G, van Damme P, Ciarlet M, Adams EM, Rida W, Wen J, MacDonald M, Price J, Kanesa-Thasan N.   +13 more
europepmc   +1 more source

Allosteric Regulation of RNA Affinity by Motif V‐VI Coupling in West Nile Virus NS3 Helicase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 6, Page 1212-1224, June 2026.
ABSTRACT The rise of flaviviral diseases, including West Nile virus (WNV), presents a growing threat to global public health and underscores the urgent need for new therapeutic strategies. The non‐structural protein 3 helicase (NS3h) of the Orthoflavivirus genus, including WNV, is essential for viral replication and a promising antiviral target ...
Priti Roy, Martin McCullagh
wiley   +1 more source