Results 41 to 50 of about 31,151 (261)
Vaccine Potential of Nipah Virus-Like Particles
PLoS ONE, 2011 Nipah virus (NiV) was first recognized in 1998 in a zoonotic disease outbreak associated with highly lethal febrile encephalitis in humans and a predominantly respiratory disease in pigs. Periodic deadly outbreaks, documentation of person-to-person transmission, and the potential of this virus as an agent of agroterror reinforce the need for effective ...
Walpita P. +4 more
openaire +4 more sources
Virus-like particles as universal influenza vaccines [PDF]
Expert Review of Vaccines, 2012 Current influenza vaccines are primarily targeted to induce immunity to the influenza virus strain-specific hemagglutinin antigen and are not effective in controlling outbreaks of new pandemic viruses. An approach for developing universal vaccines is to present highly conserved antigenic epitopes in an immunogenic conformation such as virus-like ...
Sang-Moo, Kang +2 more
openaire +2 more sources
Synthetic biology for bioengineering virus‐like particle vaccines [PDF]
Biotechnology and Bioengineering, 2018 AbstractVaccination is the most effective method of disease prevention and control. Many viruses and bacteria that once caused catastrophic pandemics (e.g., smallpox, poliomyelitis, measles, and diphtheria) are either eradicated or effectively controlled through routine vaccination programs.
Hayley K. Charlton Hume +5 more
openaire +5 more sources
Virus-Like-Vaccines against HIV
Vaccines, 2018 Protection against chronic infections has necessitated the development of ever-more potent vaccination tools. HIV seems to be the most challenging foe, with a remarkable, poorly immunogenic and fragile surface glycoprotein and the ability to overpower ...
Anne-Marie C. Andersson +2 more
doaj +1 more source
The coming of age of virus-like particle vaccines
bchm, 2008 Abstract Virus-like particles are supra-molecular assemblages, usually icosahedral or rod-like structures. They incorporate key immunologic features of viruses which include repetitive surfaces, particulate structures and induction of innate immunity through activation of pathogen-associated molecular-pattern recognition receptors.
Jennings, G, Bachmann, M
openaire +3 more sources
Advanced Functional Materials, EarlyView.The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett +19 more
wiley +1 more source
Advanced Materials, EarlyView.Inspired by viral entry mechanisms, the FUSION assay enables autonomous detection of respiratory viruses via membrane fusion–triggered CRISPR‐Cas13a activation. VEACON selectively fuses with fusion‐competent viruses, triggering fluorescence within confined vesicles.
Jae Chul Park +15 more
wiley +1 more source
Modern vaccines and coronavirus infections
Исследования и практика в медицине, 2020 Vaccines represent an outstanding success story in modern medicine and are responsible for a huge reduction in morbidity and mortality worldwide. It is clear that improvements are necessary to enable the development of successful vaccines against some ...
Yu. A. Belikova +2 more
doaj +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Vaccines, 2022 Viral diseases, including avian influenza (AI) and Newcastle disease (ND), are an important cause of morbidity and mortality in poultry, resulting in significant economic losses.
Ika Nurzijah +4 more
doaj +1 more source