Results 31 to 40 of about 31,151 (261)
Vaccines, 2021 Chikungunya virus (CHIKV) infection can result in chronic and debilitating arthralgia affecting humans in tropical and subtropical regions around the world, yet there are no licensed vaccines to prevent infection.
Jonathan O. Rayner +5 more
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Expression and Purification of Virus-like Particles for Vaccination [PDF]
Journal of Visualized Experiments, 2016 Virus-like particles (VLPs) and subviral particles (SVPs) are an alternative approach to viral vaccine design that offers the advantages of increased biosafety and stability over use of live pathogens. Non-infectious and self-assembling, VLPs are used to present structural proteins as immunogens, bypassing the need for live pathogens or recombinant ...
Maria T, Arevalo +2 more
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Plant-derived virus-like particles as vaccines [PDF]
Human Vaccines & Immunotherapeutics, 2013 Virus-like particles (VLPs) are self-assembled structures derived from viral antigens that mimic the native architecture of viruses but lack the viral genome. VLPs have emerged as a premier vaccine platform due to their advantages in safety, immunogenicity, and manufacturing.
Qiang, Chen, Huafang, Lai
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Virus-like Particle Vaccines: A Prospective Panacea Against an Avian Influenza Panzootic
Vaccines, 2020 Epizootics of highly pathogenic avian influenza (HPAI) have resulted in the deaths of millions of birds leading to huge financial losses to the poultry industry worldwide. The roles of migratory wild birds in the harbouring, mutation, and transmission of
Nathaniel Nyakaat Ninyio +5 more
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Virus-like particles as vaccine.
Acta Biochimica Polonica, 2014 This review presents data on commercial and experimental virus-like particle (VLP) vaccines, including description of VLP vaccines against influenza. Virus-like particles are multimeric, sometimes multiprotein nanostructures assembled from viral structural proteins and are devoid of any genetic material. VLPs present repetitive high-density displays of
Jadwiga, Chroboczek +2 more
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Journal of Biological Engineering, 2019 Background Influenza viruses cause hundreds of thousands of respiratory diseases worldwide each year, and vaccination is considered the most effective approach for preventing influenza annual epidemics or pandemics.
Chia-Chun Lai +7 more
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Platforms, advances, and technical challenges in virus-like particles-based vaccines
Frontiers in Immunology, 2023 Viral infectious diseases threaten human health and global stability. Several vaccine platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based vaccines have been developed to counter these viral infectious diseases.
Reeshu Gupta +6 more
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Influenza vaccines based on virus-like particles [PDF]
Virus Research, 2009 The simultaneous expression of structural proteins of virus can produce virus-like particles (VLPs) by a self-assembly process in a viral life cycle even in the absence of genomic material. Taking an advantage of structural and morphological similarities of VLPs to native virions, VLPs have been suggested as a promising platform for new viral vaccines.
Sang-Moo, Kang +3 more
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Cross-Protection Induced by Virus-like Particles Derived from the Influenza B Virus
Biomedicines, 2022 The mismatch between the circulating influenza B virus (IBV) and the vaccine strain contributes to the rapid emergence of IBV infection cases throughout the globe, which necessitates the development of effective vaccines conferring broad protection. Here,
Hae-Ji Kang +5 more
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Virus-like particles as vaccine adjuvants
Molecular Biotechnology, 2001 Virus-like particles (VLPs) consist of one or more viral coat proteins that assemble into particles. They can be taken up by antigen presenting cells (APC), peptides derived from them are presented on MHC class I molecules at the cell surface, and thereby prime a CD8+ T cell response, either against the particle-forming protein itself (such as ...
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