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Next generation designer virus-like particle vaccines for dengue
Expert Review of Vaccines, 2019 Introduction: A safe and efficacious vaccine for dengue continues to be an unmet public health need. The recent licensing of a dengue vaccine (Dengvaxia) developed by Sanofi has brought to the fore the safety issue of vaccine-induced infection ...
Rahul Shukla +8 more
doaj +1 more source
Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse Models. [PDF]
, 2018 Zika virus (ZIKV) infection during the large epidemics in the Americas is related to congenital abnormities or fetal demise. To date, there is no vaccine, antiviral drug, or other modality available to prevent or treat Zika virus infection.
Hu, Q +12 more
core +1 more source
Vaccines, 2021 Chikungunya virus (CHIKV) infection can result in chronic and debilitating arthralgia affecting humans in tropical and subtropical regions around the world, yet there are no licensed vaccines to prevent infection.
Jonathan O. Rayner +5 more
doaj +1 more source
Chemical-free inactivated whole influenza virus vaccine prepared by ultrashort pulsed laser treatment [PDF]
, 2014 There is an urgent need for rapid methods to develop vaccines in response to emerging viral pathogens. Whole inactivated virus (WIV) vaccines represent an ideal strategy for this purpose; however, a universal method for producing safe and immunogenic ...
Achilefu, Samuel +10 more
core +2 more sources
Engineering virus-like particles as vaccine platforms [PDF]
Current Opinion in Virology, 2016 Virus-like particles (VLPs) have been utilized as vaccine platforms to increase the immunogenicity of heterologous antigens. A variety of diverse VLP types can serve as vaccine platforms, and research has focused on engineering VLPs to improve their efficacy as vaccines, enhance their stability, and allow for more versatile display of antigens.
Kathryn M Frietze +2 more
openaire +2 more sources
Virus-like Particle Vaccines: A Prospective Panacea Against an Avian Influenza Panzootic
Vaccines, 2020 Epizootics of highly pathogenic avian influenza (HPAI) have resulted in the deaths of millions of birds leading to huge financial losses to the poultry industry worldwide. The roles of migratory wild birds in the harbouring, mutation, and transmission of
Nathaniel Nyakaat Ninyio +5 more
doaj +1 more source
Development of an experimental inactivated PRRSV vaccine that induces virus-neutralizing antibodies [PDF]
, 2009 Porcine reproductive and respiratory syndrome virus (PRRSV) can induce reproductive disorders and is involved in the porcine respiratory disease complex, causing tremendous economic losses to the swine industry.
Delputte, Peter +4 more
core +3 more sources
Leaf-Encapsulated Vaccines: Agroinfiltration and Transient Expression of the Antigen Staphylococcal Endotoxin B in Radish Leaves. [PDF]
, 2018 Transgene introgression is a major concern associated with transgenic plant-based vaccines. Agroinfiltration can be used to selectively transform nonreproductive organs and avoid introgression.
Gallo, Richard L +6 more
core +3 more sources
Influenza vaccines based on virus-like particles [PDF]
Virus Research, 2009 The simultaneous expression of structural proteins of virus can produce virus-like particles (VLPs) by a self-assembly process in a viral life cycle even in the absence of genomic material. Taking an advantage of structural and morphological similarities of VLPs to native virions, VLPs have been suggested as a promising platform for new viral vaccines.
Sang-Moo, Kang +3 more
openaire +2 more sources
Journal of Biological Engineering, 2019 Background Influenza viruses cause hundreds of thousands of respiratory diseases worldwide each year, and vaccination is considered the most effective approach for preventing influenza annual epidemics or pandemics.
Chia-Chun Lai +7 more
doaj +1 more source