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Diminished Intracellular Invariant Chain Expression Following Vaccinia Virus Infection [PDF]
Vaccinia virus (VV) has been used as a vaccine to eradicate smallpox and as a vaccine for HIV and tumors. However, the immunoevasive properties of VV, have raised safety concerns.
Blum, Janice S.+2 more
core +1 more source
Abstract In the increasingly likely event of an engineered‐virus outbreak or pandemic of catastrophic potential, managing infectious aerosols to reduce transmission will be crucial. Now is the time to start preparing our buildings, public opinion, and regulatory environments for the infectious aerosol management interventions necessary to protect the ...
Adam Lerner+7 more
wiley +1 more source
Morphology of deoxyribonucleic acid extracted from cores of vaccinia virus [PDF]
It has been shown recently that the outer layers of vaccinia virions can be removed selectively under mild conditions to yield a preparation that consists entirely of "cores" (K. B. Easterbrook, Ultrastruct. Res. 14:484, 1966).
Easterbrook, K. B.
core
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu+6 more
wiley +1 more source
Dairy production practices and associated risks for bovine vaccinia exposure in cattle, Brazil
A cross-sectional serosurvey was performed to identify environmental features or practices of dairy farms associated with risk for exposure to vaccinia-like viruses in dairy cattle in Brazil.
I.A. Borges+10 more
doaj +1 more source
Background Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property.
Yuedi Ding+4 more
doaj +1 more source
Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein [PDF]
Processing of endogenously synthesized proteins generates short peptides that are presented by MHC class I molecules to CD8 T lymphocytes. Here it is documented that not only the sequence of the presented peptide but also the residues by which it is ...
Braciale+36 more
core +1 more source
Ovarian cancer‐derived extracellular vesicles (EVs) transfer INAVA mRNA to normal ovarian fibroblasts (NOFs). Translated INAVA protein inhibits HMGA2 phosphorylation‐dependent ubiquitylation and proteasomal degradation, promoting NOF activation.
Lingkai Gu+12 more
wiley +1 more source