Results 71 to 80 of about 63,132 (220)

Retrospective Analysis of Monkeypox Infection

Emerging Infectious Diseases, 2008
Serologic cross-reactivity between orthopoxviruses is a substantial barrier to laboratory diagnosis of specific orthopoxvirus infections and epidemiologic characterization of disease outbreaks.
Melissa E. Dubois, Mark K. Slifka
doaj   +1 more source

An intradermal model for vaccinia virus pathogenesis in mice

, 2016
Intradermal injection of vaccinia virus in the ear pinnae of mice provides a model of dermal infection and vaccination. The key features of this model are the appearance of a lesion on the surface of the ear that can be measured as a clinical sign of ...
Smith, Stewart, Lin, Chien-Wei (Leon), Tscharke, David   +2 more
core   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Induction and in Vitro demonstration of cellular immunity to DNA and RNA viruses in guinea-pigs [PDF]

, 1975
Guinea-pigs were immunized with different cells infected with vaccinia virus, herpes simplex virus type 1, herpesvirus saimiri, and the virus of vesicular stomatitis. Development of cellular immunity against these viruses was observed with transformation
Koszinowski, Ulrich H., Bandlow, G.
core   +1 more source

Progressive vaccinia acquired through zoonotic transmission in a patient with HIV/AIDS, Colombia

, 2020
In March 2015, a patient in Colombia with HIV/AIDS was hospitalized for disseminated ulcers after milking cows that had vesicular lesions on their udders.
Styczynski A., Li Y., Laiton-Donato K., Davidson W., Giraldo I., Ávila-Robayo P., Gracia-Romero M., Páez-Martinez A., Wilkins K., Satheshkumar P.S., Usme-Ciro J.A., Burgado J., Benjumea-Nieto P., Mauldin M.R., Patel N., Petersen B.W., Nakazawa Y., Pinzón-Nariño N., Torres-Castellanos D., Mauldin, Matthew R., Kimberly Wilkins, Benjumea Nieto, Paula, Panayampalli Subbian Satheshkumar, Torres-Castellanos, Diego, Brett W. Petersen, Ávila-Robayo, Paola, Gracia Romero, Martha, Usme Ciro, José Aldemar, Petersen, Brett W., Usme-Ciro, José A., Yu Li, Whitni Davidson, Paola Ávila-Robayo, Nishi Patel, Pinzón-Nariño, Nicole, Martha Gracia-Romero, Paula Benjumea-Nieto, Ivan Giraldo, Satheshkumar, Panayampalli S., Laiton Donato, Katherine, Nakazawa, Yoshinori, Jillybeth Burgado, Avila Robayo, Paola, Laiton-Donato, Katherine, Patel, Nishi, Li, Yu, Páez Martínez, Andrés, Pinzón Nariño, Nicole, Diego Torres-Castellanos, Nicole Pinzón-Nariño, Satheshkumar, Panayampalli Subbian, Katherine Laiton-Donato, Matthew R. Mauldin, Yoshinori Nakazawa, Wilkins, Kimberly, Páez-Martinez, Andrés, Giraldo, Ivan, Styczynski, Ashley, Davidson, Whitni, Gracia-Romero, Martha, Burgado, Jillybeth, Torres Castellanos, Diego, Benjumea-Nieto, Paula, José A. Usme-Ciro, Ashley Styczynski, Andrés Páez-Martinez   +65 more
core   +2 more sources

VACCINIA AND VARIOLA. [PDF]

The Lancet, 1888
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openaire   +2 more sources

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Nathan W. Bartlett, Geoffrey L. Smith, Haga, Ismar R, Geraldine Maloney, Bowie, Andrew G., Bartlett, Nathan W., Martina Schröder, Ismar R. Haga, Haga, Ismar R., Patrick C. Reading, Andrew G. Bowie, Fitzgerald, Katherine A, Smith, Geoffrey L, Schroeder, Martina, Reading, Patrick C, Smith, Geoffrey L., Katherine A. Fitzgerald, Bartlett, Nathan W, Julianne Stack, Maloney, Geraldine, Bowie, Andrew G, Schröder, Martina, Reading, Patrick C., Stack, Julianne, Fitzgerald, Katherine A., Reading, Patrick   +25 more
core   +1 more source

Vaccinia virus-based vector against infectious diseases and tumors

, 2021
Vaccinia virus was used to prevent smallpox. After the World Health Organization declared smallpox extinct, vaccinia virus has been explored for the development of vaccines against a variety of infectious diseases.
Ziling Zhang, Lanlan Dong, Jianqing Xu, Chen Zhao, Peiyong Zheng, Xiaoyan Zhang   +5 more
core   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa. [PDF]

, 2011
Viral infection is a stimulus for apoptosis, and in order to sustain viral replication many viruses are known to carry genes encoding apoptosis inhibitors. F1L, encoded by the orthopoxvirus modified vaccinia virus Ankara (MVA) has a Bcl-2-like structure.
Potthoff, Stephanie, Häcker Georg, Sutter Gerd, Kastenmüller, Wolfgang, Drexler, I., Eitz Ferrer Pedro, Ludwig, H., Gasteiger Georg, Sutter, G., Gasteiger, Georg, Holger Ludwig, Stefan A Paschen, Stefan A. Paschen, Stephanie Potthoff, Potthoff, S., Susanne Kirschnek, Kirschnek, Susanne, Kastenmüller Wolfgang, Pedro Eitz Ferrer, Kirschnek, S., Häcker, Georg, Potthoff Stephanie, Villunger Andreas, Georg Gasteiger, Villunger, A., Ludwig, Holger, Georg Häcker, Drexler Ingo, Wolfgang Kastenmüller, Villunger, Andreas, Ingo Drexler, Gasteiger, G., Paschen, Stefan A., Sutter, Gerd, Häcker, G., Eitz Ferrer, Pedro, Kastenmüller, W., Kirschnek Susanne, Paschen Stefan A., Gerd Sutter, Ludwig Holger, Paschen, S.A., Andreas Villunger, Eitz Ferrer, P., Drexler, Ingo, Eitz Ferrer, P;Potthoff, S;Kirschnek, S;Gasteiger, G;Kastenmuller, W;Ludwig, H;Paschen, SA;Villunger, A;Sutter, G;Drexler, I;Häcker, G   +45 more
core   +2 more sources