Transcriptional mapping of the DNA polymerase gene of vaccinia virus [PDF]
, 1984 Paula Traktman +3 more
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ChemMedChem, Volume 21, Issue 2, January 2026.5′ Cap modifications can be introduced via enzymes or chemical synthesis. Natural and non‐natural 5′ cap structures affect mRNA properties, including translation (T), stability (S), and/or immunogenicity (I). Eukaryotic mRNAs made by in vitro transcription have emerged as medical modalities for vaccination and protein replacement therapy. The 5′ cap is
Greta Charlotte Dahm +3 more
wiley +1 more source
Reemergence of Vaccinia Virus during Zoonotic Outbreak, Pará State, Brazil
Emerging Infectious Diseases, 2013 In 2010, vaccinia virus caused an outbreak of bovine vaccinia that affected dairy cattle and rural workers in Pará State, Brazil. Genetic analyses identified the virus as distinct from BeAn58058 vaccinia virus (identified in 1960s) and from smallpox ...
Felipe L. de Assis +9 more
doaj +1 more source
Microglial VRK2 Regulates Astrocytic GABA Synthesis and Tonic Inhibition in the Thalamus
Glia, Volume 74, Issue 1, January 2026.In Vrk2‐deficient mice, tonic GABA inhibition is reduced in the mediodorsal thalamus due to impaired astrocytic GABA synthesis. Microglial VRK2 regulates this process via TNF‐α signaling, revealing a glial–glial mechanism of thalamic inhibition.
Dongsu Lee +10 more
wiley +1 more source
Mediation of antitumor activity by AZD4820 oncolytic vaccinia virus encoding IL-12
Molecular Therapy: OncologyOncolytic viruses are engineered to selectively kill tumor cells and have demonstrated promising results in early-phase clinical trials. To further modulate the innate and adaptive immune system, we generated AZD4820, a vaccinia virus engineered to ...
Cheyne Kurokawa +21 more
doaj +1 more source
Monkeypox Virus: Epidemiology, Virology, Diagnosis, Vaccine, and Therapeutics
MedComm, Volume 7, Issue 1, January 2026.This review provides a comprehensive overview of the latest research advances in MPXV, with a focused analysis across five core dimensions: epidemiology, virology, diagnosis, vaccine, and therapeutics. The primary objective of this review is to advance the understanding of MPXV and facilitate the development of more effective diagnostic methods ...
Yunzheng Yan +14 more
wiley +1 more source
Resolution of vaccinia virus DNA concatemer junctions requires late-gene expression [PDF]
, 1989 Michael Merchlinsky, Bernard Moss
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Synthesizing current knowledge on the ecology, phenology, and cultivation of Vaccinium membranaceum
PLANTS, PEOPLE, PLANET, Volume 8, Issue 1, Page 116-133, January 2026.More than 100 edible native berries grow across Canada's vast territory and are used by over 600 Indigenous Peoples of Canada as a main component of their diet. This research provides critical insights into the ecology, phenology, and cultivation of black huckleberry (Vaccinium membranaceum), a species of significant ecological and cultural importance ...
Mehdi Sharifi +12 more
wiley +1 more source
Vaccination with a Fusion Protein That Introduces HIV-1 Gag Antigen into a Multitrimer CD40L Construct Results in Enhanced CD8 + T Cell Responses and Protection from Viral Challenge by Vaccinia-Gag [PDF]
, 2013 Sachin Gupta +5 more
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