Results 31 to 40 of about 98,253 (278)

Conserved Oligomeric Golgi (COG) Complex Proteins Facilitate Orthopoxvirus Entry, Fusion and Spread

Viruses, 2020
Although orthopoxviruses (OPXV) are known to encode a majority of the genes required for replication in host cells, genome-wide genetic screens have revealed that several host pathways are indispensable for OPXV infection.
Susan Realegeno, Lalita Priyamvada, Amrita Kumar, Jessica B. Blackburn, Claire Hartloge, Andreas S. Puschnik, Suryaprakash Sambhara, Victoria A. Olson, Jan E. Carette, Vladimir Lupashin, Panayampalli Subbian Satheshkumar   +10 more
doaj   +1 more source

An mRNA Vaccine Based on Antigens From Conserved Regions of Monkeypox Virus A35R and M1R With a Dimer-Like Conformation Confers Protection Against Both Monkeypox Virus and Vaccinia Virus Infections in Mice. [PDF]

MedComm (2020)
We developed four candidate mRNA vaccine antigens based on conserved sequences of MPXV A35R and M1R proteins. Our findings demonstrate that the MV2 vaccine possesses favorable immunogenicity and prophylactic potential against MPXV and VACV infections, positioning it as a promising clinical candidate for MPXV prevention.
Tang C, Yuan L, Xie Y, Yang Y, Zhou Y, Wang J, Yang H, Peng R, Xu J, Yu W, Huang Q, Quan W, Li B, Wang Y, Lu S.   +14 more
europepmc   +2 more sources

Truncation of gene F5L partially masks rescue of vaccinia virus strain MVA growth on mammalian cells by restricting plaque size [PDF]

, 2015
Modified vaccinia virus Ankara (MVA) is a candidate vaccine vector that is severely attenuated due to mutations acquired during several hundred rounds of serial passage in vitro.
Dobson, Bianca, Tscharke, David C.
core   +1 more source

Identification of sites phosphorylated by the vaccinia virus B1R kinase in viral protein H5R [PDF]

, 2000
Background: Vaccinia virus gene B1R encodes a erine/threonine protein kinase. In vitro this protein kinase phosphorylates ribosomal proteins Sa and S2 and vaccinia virus protein H5R, proteins that become phosphorylated during infection.
Beaud, G., Brown, N.G., Hardie, G., Leader, D.P., Morrice, D.N.   +4 more
core   +3 more sources

A Quadrivalent mRNA Immunization Elicits Potent Immune Responses against Multiple Orthopoxviral Antigens and Neutralization of Monkeypox Virus in Rodent Models

Vaccines
The global outbreak of the 2022 monkeypox virus infection of humans and the 2023 documentation of a more virulent monkeypox in the Democratic Republic of the Congo raised public health concerns about the threat of human-to-human transmission of zoonotic ...
Caixia Su, Sha Li, Yang Wen, Xiya Geng, Quanyi Yin, Yun Wang, Yelin Xiong, Zhihua Liu   +7 more
doaj   +1 more source

Should Remaining Stockpiles of Smallpox Virus (Variola) Be Destroyed?

Emerging Infectious Diseases, 2011
In 2011, the World Health Organization will recommend the fate of existing smallpox stockpiles, but circumstances have changed since the complete destruction of these cultures was first proposed.
Raymond S. Weinstein
doaj   +1 more source

Plasmablast, Memory B Cell, CD4+ T Cell, and Circulating Follicular Helper T Cell Responses to a Non-Replicating Modified Vaccinia Ankara Vaccine

Vaccines, 2020
Background: Vaccinia is known to induce antibody and cellular responses. Plasmablast, circulating follicular helper T (cTFH) cells, cytokine-expressing CD4 T cells, and memory B cells were compared between subcutaneous (SC) and needle-free jet injection (
Evan J. Anderson, Lilin Lai, Jens Wrammert, Sarah Kabbani, Yongxian Xu, Lalita Priyamvada, Heather Hill, Johannes B. Goll, Travis L. Jensen, Carol Kao, Inci Yildirim, Nadine Rouphael, Lisa Jackson, Mark J. Mulligan   +13 more
doaj   +1 more source

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources

Secondary and Tertiary Transmission of Vaccinia Virus from US Military Service Member

Emerging Infectious Diseases, 2011
During February and March 2010, the New York State Department of Health investigated secondary and tertiary vaccinia contact transmission from a military vaccinee to 4 close contacts.
Gregory E. Young, Christina M. Hidalgo, Ann Sullivan-Frohm, Cynthia Schulte, Stephen Davis, Cassandra Kelly-Cirino, Christina Egan, Kimberly Wilkins, Ginny L. Emerson, Kimberly Noyes, Debra Blog   +10 more
doaj   +1 more source

Transcriptional reprogramming of natural killer cells by vaccinia virus shows both distinct and conserved features with mCMV

Frontiers in Immunology, 2023
Natural killer (NK) cells have an established role in controlling poxvirus infection and there is a growing interest to exploit their capabilities in the context of poxvirus-based oncolytic therapy and vaccination.
Delphine M. Depierreux, Geoffrey L. Smith, Brian J. Ferguson   +2 more
doaj   +1 more source