Results 51 to 60 of about 76,843 (254)

Histone Lactylation‐Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells

Advanced Science, EarlyView.
Glioblastoma (GBM) is the most aggressive primary brain tumor, with glioma stem cells (GSCs) driving treatment resistance. This study reveals that lactate promotes histone lactylation (H3K18la) at the VRK1 promoter, regulating GSC stemness and proliferation via the H3K18la/VRK1/YBX1/SOX2 pathway. The VRK1‐targeted nanoliposome A/TMZ‐siVRK1 demonstrates
Jinna Li, Chenyue Tang, Xuefeng Zhang, Rui Xing, Qing Guo   +4 more
wiley   +1 more source

Gigaxonin Potentiates Antiviral Innate Immune Responses by Targeting cGAS and TREX1

Advanced Science, EarlyView.
TREX1 antagonizes DNA sensor cGAS by degrading cytosolic DNA. This work identifies gigaxonin as a molecular switch that coordinates DNA sensing and clearance pathways to amplify antiviral responses. Under the steady state, gigaxonin maintains cellular homeostasis by mediating TREX1 ubiquitination and proteasomal degradation. During DNA virus infection,
Ben‐Zhe Ji, Jie Wang, Yi Tu, Shan Zhang, Yong‐Sheng Wei, Yan He, Bin Zhang, Qing‐Qing Zhao, Hao‐Min Hu, Yu Liu   +9 more
wiley   +1 more source

Recombinant chimeric horsepox virus (TNX-801) is attenuated relative to vaccinia virus strains in both in vitro and in vivo models

mSphere
Recombinant chimeric horsepox virus (TNX-801) is a preclinical vaccine in development against mpox and smallpox. In this report, we investigated the potential phenotypic differences in in vitro and in vivo models between TNX-801 and older vaccinia virus (
Stephanie V. Trefry, Mayanka Awasthi, Christy N. Raney, Amy L. Cregger, Chase A. Gonzales, Brittney L. Layton, Robert N. Enamorado, Nelson A. Martinez, Deborah S. Gohegan, Masoudeh Masoud-Bahnamiri, Jennifer Y. Cho, Dawn M. Myscofski, Tinoush Moulaei, Natasza E. Ziółkowska, Scott J. Goebel, Seth Lederman, Sina Bavari, Farooq Nasar   +17 more
doaj   +1 more source

Dairy production practices and associated risks for bovine vaccinia exposure in cattle, Brazil

New Microbes and New Infections, 2017
A cross-sectional serosurvey was performed to identify environmental features or practices of dairy farms associated with risk for exposure to vaccinia-like viruses in dairy cattle in Brazil.
I.A. Borges, A.M. McCollum, J.M. Mehal, D. Haberling, L.A.L. Dutra, F.N. Vieira, L.A.O. Andrade, E.G. Kroon, R.C. Holman, M.G. Reynolds, G.S. Trindade   +10 more
doaj   +1 more source

First-in-man study of western reserve strain oncolytic vaccinia virus: safety, systemic spread, and antitumor activity.

Molecular Therapy, 2015
Oncolytic viral therapy utilizes a tumor-selective replicating virus which preferentially infects and destroys cancer cells and triggers antitumor immunity.
Herbert J. Zeh, Stephanie Downs-Canner, J. McCart, Zongbi Guo, Uma N M Rao, Lekshmi Ramalingam, Stephen H Thorne, H. Jones, P. Kalinski, E. Wieckowski, M. O’Malley, M. Daneshmand, K. Hu, John C. Bell, T. Hwang, A. Moon, C. Breitbach, D. Kirn, David L. Bartlett   +18 more
semanticscholar   +1 more source

In Situ Vaccines in the Era of Cancer Immunotherapy: Conceptual Innovation and Clinical Translation

Advanced Science, EarlyView.
In this review, the basic concepts of in situ vaccination are discussed, its advantages over conventional vaccines, and key historical milestones, from the first use of Coley's toxins to the most recent FDA‐approved in situ vaccine for bladder cancer.
Yiru Shi, Yuxuan Hou, Moustafa T. Mabrouk, Chengzhong Yu, Yannan Yang   +4 more
wiley   +1 more source

Safety and Immunogenicity of Modified Vaccinia Ankara-Bavarian Nordic Smallpox Vaccine in Vaccinia-Naive and Experienced Human Immunodeficiency Virus-Infected Individuals: An Open-Label, Controlled Clinical Phase II Trial

Open Forum Infectious Diseases, 2015
Background First- and second-generation smallpox vaccines are contraindicated in individuals infected with human immunodeficiency virus (HIV). A new smallpox vaccine is needed to protect this population in the context of biodefense preparedness.
E. Overton, J. Stapleton, I. Frank, Shawn Hassler, P. Goepfert, David E. Barker, E. Wagner, A. von Krempelhuber, G. Virgin, J. Weigl, T. Meyer, Jutta Müller, Nicole Bädeker, Robert Gruenert, P. Young, Siegfried Rösch, J. Maclennan, Nathaly Arndtz-Wiedemann, P. Chaplin   +18 more
semanticscholar   +1 more source

Engineered Nile Red Derivatives‐Mediated Efficient Phototherapy Against Drug‐Resistant Bacteria and Monkeypox Virus

Aggregate, EarlyView.
TPAOMCN exhibits optimal reactive oxygen species (ROS) generation and photothermal conversion properties. TPAOMCN nanofibers (NFs)‐mediated photodynamic (PDT) and photothermal therapy (PTT) achieved efficient eradication against multidrug‐resistant bacteria and viruses, alleviating inflammation response, promoting wound healing, and providing a ...
Laiping Fang, Wei Wang, Jianan Dai, Yike Tu, Shufang Li, Kuo He, Siya Tong, Yuhui Liao, Ping'an Ma, Guihua Jiang   +9 more
wiley   +1 more source

Harvesting AAV by tangential flow filtration using reverse asymmetric membranes

Biotechnology Progress, EarlyView.
Abstract Efficient bioreactor clarification for harvesting virus particles is often challenging. Tangential flow filtration is attractive as it can be easily adapted for batch and perfusion operations. Here the feasibility of using reverse asymmetric hollow fiber membranes, where the more open support structure faces the feed stream, has been ...
Xiaolei Hao, Ronny Horax, Xianghong Qian, April Wheeler, Hironobu Shirataki, S. Ranil Wickramasinghe   +5 more
wiley   +1 more source

Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?

Viruses, 2015
The last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm for oncolytic virotherapy, with a large amount of pre-clinical data showing promise in animal ...
Samantha Turnbull, Emma J. West, Karen J. Scott, Elizabeth Appleton, Alan Melcher, Christy Ralph   +5 more
doaj   +1 more source