Results 51 to 60 of about 56,773 (216)

VRK1 Is a Novel Therapeutic Target for Small Cell Neuroendocrine Carcinoma of the Cervix

Cancer Science, EarlyView.
Small cell neuroendocrine carcinoma of the cervix (SCNEC), a rare but aggressive cancer, consistently exhibited high VRK1 expression. VRK1 knockdown significantly suppressed xenograft tumor growth by inducing mitochondrial dysfunction. These findings highlighted VRK1 as a potential therapeutic target for SCNEC.
Mariya Kobayashi, Satoshi Nakagawa, Yusuke Ishii, Yuji Kamei, Mizuki Kanda, Tatsuo Masuda, Mamoru Kakuda, Kosuke Hiramatsu, Tadashi Iwamiya, Tomomi Egawa‐Takata, Shinya Matsuzaki, Hiroyuki Uematsu, Kunishige Onuma, Masahiro Inoue, Yutaka Ueda, Tadashi Kimura, Michiko Kodama   +16 more
wiley   +1 more source

Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease

Microbiology Spectrum
Although smallpox has been eradicated, other orthopoxviruses continue to be a public health concern as exemplified by the ongoing Mpox (formerly monkeypox) global outbreak.
Rajini R. Mudhasani, Joseph W. Golden, Gregory C. Adam, Timothy J. Hartingh, Krishna P. Kota, David Ordonez, Corey R. Quackenbush, Julie P. Tran, Curtis Cline, Janice A. Williams, Xiankun Zeng, David B. Olsen, Linda A. Lieberman, Christopher Boyce, Anthony Ginnetti, J. Matthew Meinig, Rekha G. Panchal, Eric M. Mucker   +17 more
doaj   +1 more source

Vaccinia virus-based vector against infectious diseases and tumors

Human Vaccines & Immunotherapeutics, 2021
Vaccinia virus was used to prevent smallpox. After the World Health Organization declared smallpox extinct, vaccinia virus has been explored for the development of vaccines against a variety of infectious diseases.
Ziling Zhang, Lanlan Dong, Chen Zhao, Peiyong Zheng, Xiaoyan Zhang, Jianqing Xu   +5 more
doaj   +1 more source

Mpox and the Ethics of Outbreak Management: Lessons for Future Public Health Crises

Developing World Bioethics, EarlyView.
ABSTRACT Mpox, first identified in captive monkeys in 1958 and recognized in humans by 1970 in the Democratic Republic of Congo, was historically confined to sporadic zoonotic outbreaks in Central and West Africa. These outbreaks, often driven by rodent‐to‐human transmission in resource‐limited settings, reflect persistent systemic health disparities ...
Adetayo E. Obasa, Marietjie Botes, Anita Kleinsmidt, Ciara Staunton   +3 more
wiley   +1 more source

Smallpox Vaccination of Laboratory Workers at US Variola Testing Sites

Emerging Infectious Diseases, 2015
To evaluate the need to revaccinate laboratory workers against smallpox, we assessed regular revaccination at the US Laboratory Response Network’s variola testing sites by examining barriers to revaccination and the potential for persistence of immunity.
Sharon Medcalf, Laura Bilek, Teresa Hartman, Peter C. Iwen, Patricia Leuschen, Hannah Miller, Anne O’Keefe, Harlan Sayles, Philip W. Smith   +8 more
doaj   +1 more source

LAG‐3+ Regulatory T Cells Suppress Effector Function of T Cells and Allow Their Proliferation Into Regulatory T Cells

Immunology, EarlyView.
LAG‐3+ regulatory T cells suppress the effector but not the proliferative response of naïve cognate antigen‐specific CD4+ T cells in vivo. The suppressed T cells display upregulation of immune checkpoints and downregulation of pro‐inflammatory pathways with enhanced TCR signaling and reduced oxidative metabolism.
Avijit Dutta, Shi‐Chuen Miaw, Tse‐Ching Chen, Chia‐Shiang Chang, Yu‐Lin Huang, Yung‐Chang Lin, Chun‐Yen Lin, Ching‐Tai Huang   +7 more
wiley   +1 more source

Genomic identification of human vaccinia virus keratoconjunctivitis and its importance as a laboratory-acquired infection

Indian Journal of Ophthalmology, 2016
Context: Vaccinia virus (VACV) is a member of orthopoxvirus genus of the family Poxviridae. VACVs are enveloped, double-stranded DNA viruses. Several species of this family, for example, molluscum contagiosum, smallpox, deerpox, horsepox, rabbitpox, and ...
Zahra Movahedi Motlagh, Azam Mokhtari, Mohammadreza Mahzounieh   +2 more
doaj   +1 more source

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, EarlyView.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source

Antitumor efficacy of cytosine deaminase-armed vaccinia virus plus 5-fluorocytosine in colorectal cancers

Cancer Cell International, 2020
Background Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property.
Yuedi Ding, Jun Fan, Lili Deng, Biao Huang, Bin Zhou   +4 more
doaj   +1 more source

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease

Journal of Internal Medicine, EarlyView.
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron, Jennifer S. Lin, Mark I. Ryder, Peter Bergman   +3 more
wiley   +1 more source