Results 51 to 60 of about 46,668 (172)

Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease

Microbiology Spectrum
Although smallpox has been eradicated, other orthopoxviruses continue to be a public health concern as exemplified by the ongoing Mpox (formerly monkeypox) global outbreak.
Rajini R. Mudhasani, Joseph W. Golden, Gregory C. Adam, Timothy J. Hartingh, Krishna P. Kota, David Ordonez, Corey R. Quackenbush, Julie P. Tran, Curtis Cline, Janice A. Williams, Xiankun Zeng, David B. Olsen, Linda A. Lieberman, Christopher Boyce, Anthony Ginnetti, J. Matthew Meinig, Rekha G. Panchal, Eric M. Mucker   +17 more
doaj   +1 more source

Attenuation of Vaccinia Virus [PDF]

Acta Naturae, 2015
Since 1980, in the post-smallpox vaccination era the human population has become increasingly susceptible compared to a generation ago to not only the variola (smallpox) virus, but also other zoonotic orthopoxviruses. The need for safer vaccines against orthopoxviruses is even greater now.
YAKUBITSKIY S.N., KOLOSOVA I.V., MAKSYUTOV R.A., SHCHELKUNOV S.N.   +3 more
openaire   +3 more sources

Vaccines at the Heart of Hepatitis Elimination: Insights From the ESCMID Study Group for Viral Hepatitis (ESGVH)

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT The global elimination of viral hepatitis by 2030 remains an ambitious goal that hinges not only on diagnostics and therapeutics but fundamentally on the strategic use and continued innovation of vaccines. The ESCMID Study Group for Viral Hepatitis (ESGVH) convened to examine the role of vaccination as the cornerstone of hepatitis prevention ...
Oana Săndulescu, Gülşen Özkaya Şahin, Susanne Gjeruldsen Dudman, Zeinab Nabil Ahmed Said, Mario U. Mondelli, on behalf of ESCMID Study Group for Viral Hepatitis (ESGVH)   +5 more
wiley   +1 more source

Remaining Questions about Clinical Variola Major

Emerging Infectious Diseases, 2011
After the recent summary of World Health Organization–authorized research on smallpox, several clinical issues remain. This policy review addresses whether early hemorrhagic smallpox is disseminated intravascular coagulation and speculates about the ...
J. Michael Lane
doaj   +1 more source

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

Advanced Science, Volume 13, Issue 13, 3 March 2026.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang, Xiaotian Yuan, Kelei Gao, Bo You, Yaxuan Wang, Lai Meng, Zirong Chen, Shaobing Xie, Yunqing Liu, Zijian Dong, Shumin Xie, Ruohao Fan, Fengjun Wang, Junyi Zhang, Zhihai Xie, Yongzhen Mo, Hua Zhang, Weihong Jiang   +17 more
wiley   +1 more source

Electric Method for the Desulfation of Polysaccharides From Red Microalgae (Porphyridium cruentum) Cultures

Biopolymers, Volume 117, Issue 2, March 2026.
A non‐destructive method for depleting sulfates from the red microalgae Porphyridium cruentum by directly exposing the growth medium to a moderate electric field has been developed. The reported electric‐field separation method is a simple, straightforward, and non‐toxic means for the direct recovery of desulfated polysaccharides from P.
Oshrat Levy‐Ontman, Amikam Bar‐Gil, Eli Shemesh, Mahmoud Huliehel, Yehudit Amor, Naama Landes, Yonatan Sadeh, Dan Tchernov   +7 more
wiley   +1 more source

Mediation of antitumor activity by AZD4820 oncolytic vaccinia virus encoding IL-12

Molecular Therapy: Oncology
Oncolytic viruses are engineered to selectively kill tumor cells and have demonstrated promising results in early-phase clinical trials. To further modulate the innate and adaptive immune system, we generated AZD4820, a vaccinia virus engineered to ...
Cheyne Kurokawa, Sonia Agrawal, Abhisek Mitra, Elena Galvani, Shannon Burke, Ankita Varshine, Raymond Rothstein, Kevin Schifferli, Noel R. Monks, Johann Foloppe, Nathalie Silvestre, Eric Quemeneur, Christelle Demeusoit, Patricia Kleinpeter, Puja Sapra, Carl Barrett, Scott A. Hammond, Elizabeth J. Kelly, Jason Laliberte, Nicholas M. Durham, Michael Oberst, Maria A.S. Broggi   +21 more
doaj   +1 more source

Recombinant Poxvirus and the Tumor Microenvironment: Oncolysis, Immune Regulation and Immunization

Biomedicines, 2016
Oncolytic viruses (OVs) are being extensively studied for their potential roles in the development of cancer therapy regimens. In addition to their direct lytic effects, OVs can initiate and drive systemic antitumor immunity indirectly via release of ...
Daniel W. Sharp, Edmund C. Lattime
doaj   +1 more source

An Ad26‐MVA‐BN‐based therapeutic vaccine targeting HPV16 and HPV18 related disease is immunogenic in preclinical models and in women with persistent HPV infections

Clinical &Translational Immunology, Volume 15, Issue 3, March 2026.
Immunisation with adenovirus (Ad) vectors followed by Modified Vaccinia Virus Ankara—strain Bavarian Nordic (MVA‐BN) vectors expressing HPV16 and HPV18 engineered antigens induced antigen‐specific polyfunctional T cells in mice, rhesus macaques and persistent HPV16/HPV18 infected human females vaccines (n = 5). These data showed the promise of the Ad26‐
Selina Khan, Satish Boedhoe, Miranda Baert, Jan Serroyen, Thierry Verbinnen, Ariane Volkmann, Markus Kalla, Katrin Weidner, Mathieu Le Gars, Jerry Sadoff, Michal Sarnecki, Jort Vellinga, Jerome Custers, Gert Scheper, Hanneke Schuitemaker, Roland Zahn   +15 more
wiley   +1 more source

Mass Smallpox Vaccination and Cardiac Deaths, New York City, 1947

Emerging Infectious Diseases, 2004
In April 1947, during a smallpox outbreak in New York City (NYC), >6,000,000 people were vaccinated. To determine whether vaccination increased cardiac death, we reviewed NYC death certificates for comparable periods in 1946 and 1948 (N = 81,529) and ...
Lorna E. Thorpe, Farzad Mostashari, Adam M. Karpati, Steven P. Schwartz, Susan E. Manning, Melissa A. Marx, Thomas R. Frieden   +6 more
doaj   +1 more source