Results 61 to 70 of about 76,843 (254)

Neutralization Determinants on Poxviruses

Viruses, 2023
Smallpox was a highly contagious disease caused by the variola virus. The disease affected millions of people over thousands of years and variola virus ranked as one of the deadliest viruses in human history. The complete eradication of smallpox in 1980,
Vernuccio Riccardo, Guardado-Calvo Pablo
doaj   +1 more source

ON A CASE OF VACCINIA. [PDF]

The Lancet
n ...
openaire   +2 more sources

Design and initial findings of a natural history study of anal HPV and associated lesions among young adult women in Costa Rica

International Journal of Cancer, EarlyView.
What's New? Infection with human papillomavirus (HPV) is the primary cause of anal cancer, for which the majority of cases occur in women. Anal cancer screening guidelines have limited evidence to inform effective strategies for women with HIV. We designed a study that was nested within the Costa Rica HPV Vaccine Trial to understand the natural history
Cameron B. Haas, Rebeca Ocampo, Danping Liu, Michael Zúñiga, Diego Guillen, Megan A. Clarke, Loretto J. Carvajal, Allan Hildesheim, John Schussler, Mónica Sierra, Teresa M. Darragh, Joel M. Palefsky, Carolina Porras, for the Costa Rica HPV Vaccine Trial (CVT) Group, Bernal Cortés, Paula González, Rolando Herrero, Silvia E. Jiménez, Carolina Porras, Ana Cecilia Rodríguez, Allan Hildesheim, Aimée R. Kreimer, Douglas R. Lowy, Mark Schiffman, John T. Schiller, Mark Sherman, Ligia A. Pinto, Troy J. Kemp, Leidos Biomedical Research, Frederick National Laboratory, Cancer Research, Mary K. Sidawy, Wim Quint, Joel M. Palefsky, Mark H. Stoler, Aimée R. Kreimer, Rolando Herrero   +36 more
wiley   +1 more source

Complement inhibition prevents oncolytic vaccinia virus neutralization in immune humans and cynomolgus macaques.

Molecular Therapy, 2015
Oncolytic viruses (OVs) have shown promising clinical activity when administered by direct intratumoral injection. However, natural barriers in the blood, including antibodies and complement, are likely to limit the ability to repeatedly administer OVs ...
Laura Evgin, S. Acuna, C. Tanese de Souza, M. Marguerie, Chantal G. Lemay, C. Ilkow, C. Findlay, T. Falls, K. Parato, David Hanwell, Alyssa Goldstein, Roberto Lopez, Sandra Lafrance, C. Breitbach, D. Kirn, H. Atkins, R. Auer, J. Thurman, G. Stahl, John D Lambris, J. Bell, J. McCart   +21 more
semanticscholar   +1 more source

The microbiome in cancer

iMeta, EarlyView.
This comprehensive review elucidates the transformative role of the human microbiome in cancer biology, revealing innovative mechanistic insights into the intricate tumor–microbe interactions across diverse organ systems. This work highlights the clinical and translational value of novel microbiome‐based biomarkers for early detection, prognosis, and ...
Anqi Lin, Minying Xiong, Aimin Jiang, Lihaoyun Huang, Hank Z. H. Wong, Suyin Feng, Chunyan Zhang, Yu Li, Li Chen, Hao Chi, Pengpeng Zhang, Bicheng Ye, Hengguo Zhang, Nan Zhang, Lingxuan Zhu, Weiming Mou, Junyi Shen, Kailai Li, Wentao Xu, Haoxuan Ying, Cangang Zhang, Dongqiang Zeng, Jindong Xie, Xinpei Deng, Qi Wang, Jianying Xu, Wenjie Shi, Chang Qi, Chunrun Qu, Xufeng Huang, András Hajdu, Chaoqun Li, Changmin Peng, Xuanye Cao, Guangsheng Pei, Lin Zhang, Yujia Huo, Jiabao Xu, Antonino Glaviano, Attila Gábor Szöllősi, Sicheng Bian, Zhengrui Li, Hailin Tang, Bufu Tang, Zaoqu Liu, Jian Zhang, Kai Miao, Quan Cheng, Ting Wei, Shuofeng Yuan, Peng Luo   +50 more
wiley   +1 more source

Outbreak of Severe Zoonotic Vaccinia Virus Infection, Southeastern Brazil

Emerging Infectious Diseases, 2015
In 2010, a vaccinia virus isolate caused an atypically severe outbreak that affected humans and cattle in Brazil. Of 26 rural workers affected, 12 were hospitalized.
J. Abrahão, R. K. Campos, G. Trindade, Flávio Guimarães da Fonseca, P. P. Ferreira, E. Kroon   +5 more
semanticscholar   +1 more source

Peritoneal Immunosurgery: Immunotherapy Augmented Surgery for the Treatment of Peritoneal Cancers

Journal of Surgical Oncology, EarlyView.
ABSTRACT Peritoneal malignancy often indicates disruptions in multiple physiological systems resulting from widespread cancer. The heterogenous origin and dynamic nature of peritoneal cancer make it difficult to treat with standard approaches that fit into guidelines.
Ada I. Ozcan, Arianexys Aquino López, Mary K. McKenna, Malcolm K. Brenner, Alastair M. Thompson   +4 more
wiley   +1 more source

Attenuation of Vaccinia Virus [PDF]

Acta Naturae, 2015
Since 1980, in the post-smallpox vaccination era the human population has become increasingly susceptible compared to a generation ago to not only the variola (smallpox) virus, but also other zoonotic orthopoxviruses. The need for safer vaccines against orthopoxviruses is even greater now.
YAKUBITSKIY S.N., KOLOSOVA I.V., MAKSYUTOV R.A., SHCHELKUNOV S.N.   +3 more
openaire   +4 more sources

Poxvirus-based vector systems and the potential for multi-valent and multi-pathogen vaccines

Expert Review of Vaccines, 2018
Introduction: With the increasing number of vaccines and vaccine-preventable diseases, the pressure to generate multi-valent and multi-pathogen vaccines grows.
Natalie A. Prow, Rocio Jimenez Martinez, John D. Hayball, Paul M. Howley, Andreas Suhrbier   +4 more
doaj   +1 more source

Synthesizing current knowledge on the ecology, phenology, and cultivation of Vaccinium membranaceum

PLANTS, PEOPLE, PLANET, EarlyView.
More than 100 edible native berries grow across Canada's vast territory and are used by over 600 Indigenous Peoples of Canada as a main component of their diet. This research provides critical insights into the ecology, phenology, and cultivation of black huckleberry (Vaccinium membranaceum), a species of significant ecological and cultural importance ...
Mehdi Sharifi, David Ensing, Masoumeh Bejaei, Rishi Burlakoti, Samir Debnath, Thomas Forge, Jordan Fraser, Kirsten Hannam, Janick Lorion, Jesse MacDonald, Chandra Moffat, Tyler Nelson, Hao Xu   +12 more
wiley   +1 more source