Results 91 to 100 of about 1,083,137 (225)

Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles [PDF]

, 2011
Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial.
Bridge, S., Skinner, Michael A., Anson, Donald, Dennis, M., Simon H Bridge, Dowall, S., Blanchard, Tom J., Getty, B., Stewart, James, Dennis, Mike J., Dowall, SD, Donald S Anson, Anson, D., Dennis, MJ, Bridge, Simon H., Dowall, Stuart D., Blanchard, Thomas, Stewart, JP, Blanchard, T., Skinner, M., Stewart, James P., James P Stewart, Mike J Dennis, Getty, B, Michael A Skinner, Bridge, SH, Bridge, Simon, Sharpe, Sally, Sharpe, SA, Skinner, MA, Getty, Brian, Brian Getty, Dennis, Mike, Blanchard, Tom, Sharpe, Sally A., Anson, DS, Sally A Sharpe, Skinner, Michael, Stuart D Dowall, Tom J Blanchard, Blanchard, TJ, Anson, Donald S., Stewart, J., Sharpe, S., Dowall, Stuart   +44 more
core   +1 more source

BiZyme: A Novel Fusion Protein-Mediating Selection of Vaccinia Virus Recombinants by Fluorescence and Antibiotic Resistance

BioTechniques, 2002
Recombinant vaccinia virus is a useful and powerful tool for the expression and study of foreign genes. Methods that are currently available for the selection of vaccinia virus recombinants include the restoration of viral plaque-forming phenotype, the ...
Scott G. Hansen, Torrey A. Cope, Dennis E. Hruby   +2 more
doaj   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Study of the protective properties of immunodominant proteins of orthopoxviruses in various methods of immunization

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. In 2022, the World Health Organization declared monkeypox a public health emergency. The monkeypox virus (MPV) is part of the Orthopoxvirus genus within the Poxviridae family.
Denis I. Zrelkin, Olga V. Zubkova, Tatiana A. Ozharovskaia, Olga Popova, Daria V. Voronina, Polina P. Goldovskaya, Irina V. Vavilova, Anastasia S. Chugunova, Inna V. Dolzhikova, Dmitry N. Shcherbinin, Dmitry V. Shcheblyakov, Denis Y. Logunov, Alexander L. Gintsburg   +12 more
doaj   +1 more source

Outbreak of Severe Zoonotic Vaccinia Virus Infection, Southeastern Brazil

Emerging Infectious Diseases, 2015
In 2010, a vaccinia virus isolate caused an atypically severe outbreak that affected humans and cattle in Brazil. Of 26 rural workers affected, 12 were hospitalized.
Jônatas Santos Abrahão, Rafael Kroon Campos, Giliane de Souza Trindade, Flávio Guimarães da Fonseca, Paulo César Peregrino Ferreira, Maurício Teixeira Lima   +5 more
doaj   +1 more source

Recurrent Respiratory Papillomatosis Foundation Position Statement on the Management of Adults With RRP

The Laryngoscope, Volume 136, Issue S4, Page S7-S17, September 2026.
ABSTRACT Objective With regulatory approval of HPV‐specific immunotherapy for recurrent respiratory papillomatosis (RRP) and growing experience with systemic bevacizumab, a management algorithm incorporating these medical treatments is warranted. Data Sources and Methods RRP Foundation (RRPF) Key Opinion Leaders offer a proposed management algorithm ...
Simon R. Best, Aaron D. Friedman, Clark A. Rosen, Robert T. Sataloff, Laura A. Matrka, H. Steven Sims, David E. Rosow, Nabil F. Saba, David G. Lott, Adam M. Klein, Ted Mau, Milan R. Amin, Kathryn A. Wikenheiser‐Brokamp, Scott M. Norberg, Kim McClellan, Geoffrey D. Young, Clint T. Allen, on behalf of the Recurrent Respiratory Papillomatosis Foundation   +17 more
wiley   +1 more source

Microbial Signals in Cancer: Dissecting Host–Microbiota–Tumor Interactions and Potential Therapeutic Strategy

MedComm, Volume 7, Issue 9, September 2026.
Microbial signals from gut and tumor‐resident bacteria, fungi, viruses, and bacteriophages reshape immune and metabolic networks within the tumor microenvironment, thereby influencing cancer progression, treatment response. Therapeutic modulations, including dietary interventions, probiotics, antibiotics, fecal microbiota transplantation, engineered ...
Juan Lu, Mengjuan Xuan, Liang Yu, Zhongyang Xie, Qingfei Chu, Shihui Wei, Tuokai Wang, Chen Xue, Lanjuan Li   +8 more
wiley   +1 more source

Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: Different boosting intervals and implications for efficacy trials [PDF]

, 2007
Objectives. To investigate the safety and immunogenicity of boosting BCG with modified vaccinia Ankara expressing antigen 85A (MVA85A), shortly after BCG vaccination, and to compare this first with the immunogenicity of BCG vaccination alone and second
Whelan, KT, Pathan, Ansar A, Poulton Ian, Nicola C Alder, Sander Clare R., Whelan, Kathryn T, Kathryn T Whelan, Hill, Adrian, Fletcher, Helen A, Natalie E R Beveridge, Hill, AVS, Alder, NC, Fletcher, HA, Pathan Ansar A., Hill, Adrian VS, Sander, CR, Hill Adrian V. S., McShane Helen, Beveridge Natalie E. R., Pathan, AA, Hill, AV, Beveridge, NER, Alder, Nicola C, Clare R Sander, Helen McShane, Ansar A Pathan, Beveridge, NE, Ian Poulton, Poulton, Ian, Alder Nicola C., Whelan Kathryn T., Poulton, I, Sander, Clare R, Adrian V S Hill, Helen A Fletcher, Fletcher Helen A., McShane, H, Beveridge, Natalie ER, Fletcher, Helen, McShane, Helen   +39 more
core   +1 more source

One‐Pot RPA‐CRISPR/Cas12a Assay With Visual Readout for the Ultra‐Specific Detection of Monkeypox Virus Clade I

Microbial Biotechnology, Volume 19, Issue 9, September 2026.
This study established a rapid RPA‐CRISPR/Cas12a assay for MPXV clade I detection, achieving an LOD95 of 27.16 copies/μL within 40 min. The assay exhibited no cross‐reactivity with MPXV clade II or other orthopoxviruses. Under simulated conditions, the assay detected more low‐concentration plasmid‐spiked samples than quantitative polymerase chain ...
Boyi Li, Luyao Liu, Kaikai Jin, Zanheng Huang, Tianyi Zhang, Rong Gao, Huanxin Chen, Lijuan Niu, Changqi Fan, Haili Zhang, Pei Huang, Hualei Wang   +11 more
wiley   +1 more source

Analysis of poxvirus host cell entry by electron microscopy [PDF]

, 2013
Vaccinia virus (VACV) is the prototypic poxvirus and is complex in both composition and life cycle. In contrast to most viruses, poxviruses produce two types of infectious particles with different roles in virus dissemination: Mature virions (MVs ...
Bleck, Christopher Karl Ernst
core   +1 more source