Results 71 to 80 of about 1,083,137 (225)

An intradermal model for vaccinia virus pathogenesis in mice

, 2016
Intradermal injection of vaccinia virus in the ear pinnae of mice provides a model of dermal infection and vaccination. The key features of this model are the appearance of a lesion on the surface of the ear that can be measured as a clinical sign of ...
Smith, Stewart, Lin, Chien-Wei (Leon), Tscharke, David   +2 more
core   +1 more source

Critical role of perforin-dependent CD8+ T cell immunity for rapid protective vaccination in a murine model for human smallpox [PDF]

, 2012
Vaccination is highly effective in preventing various infectious diseases, whereas the constant threat of new emerging pathogens necessitates the development of innovative vaccination principles that also confer rapid protection in a case of emergency ...
Gerd Sutter (181175), Majzoub Monir, Sutter Gerd, Kay-Martin Hanschmann (181170), Yasemin Suezer, Kalinke Ulrich, Suezer, Yasemin, Monir Majzoub (181167), Yasemin Suezer (181158), Hanschmann Kay-Martin, Theresa Frenz, Melanie Kremer (181155), Michael H. Lehmann (181173), Lehmann Michael H., Suezer Yasemin, Michael H. Lehmann, Volz Asisa, Asisa Volz (181161), Kay-Martin Hanschmann, Michael H Lehmann, Kremer, Melanie, Asisa Volz, Ulrich Kalinke, Hanschmann, Kay-Martin, Kremer Melanie, Kalinke, Ulrich, Theresa Frenz (181164), Monir Majzoub, Sutter, Gerd, Melanie Kremer, Frenz, Theresa, Ulrich Kalinke (41173), Frenz Theresa, Gerd Sutter, Lehmann, Michael H, Volz, Asisa, Majzoub, Monir, Lehmann, Michael H.   +37 more
core   +2 more sources

Compact, Synthetic, Vaccinia Virus Early/Late Promoter for Protein Expression

BioTechniques, 1997
Vaccinia virus, a member of the poxvirus family, is widely used as a mammalian cell expression vector. Vaccinia virus replicates in the cytoplasm and has its own transcriptional system, making it necessary to use viral promoters.
Sekhar Chakrabarti, Jerry R. Sisler, Bernard Moss   +2 more
doaj   +1 more source

Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa. [PDF]

, 2011
Viral infection is a stimulus for apoptosis, and in order to sustain viral replication many viruses are known to carry genes encoding apoptosis inhibitors. F1L, encoded by the orthopoxvirus modified vaccinia virus Ankara (MVA) has a Bcl-2-like structure.
Potthoff, Stephanie, Häcker Georg, Sutter Gerd, Kastenmüller, Wolfgang, Drexler, I., Eitz Ferrer Pedro, Ludwig, H., Gasteiger Georg, Sutter, G., Gasteiger, Georg, Holger Ludwig, Stefan A Paschen, Stefan A. Paschen, Stephanie Potthoff, Potthoff, S., Susanne Kirschnek, Kirschnek, Susanne, Kastenmüller Wolfgang, Pedro Eitz Ferrer, Kirschnek, S., Häcker, Georg, Potthoff Stephanie, Villunger Andreas, Georg Gasteiger, Villunger, A., Ludwig, Holger, Georg Häcker, Drexler Ingo, Wolfgang Kastenmüller, Villunger, Andreas, Ingo Drexler, Gasteiger, G., Paschen, Stefan A., Sutter, Gerd, Häcker, G., Eitz Ferrer, Pedro, Kastenmüller, W., Kirschnek Susanne, Paschen Stefan A., Gerd Sutter, Ludwig Holger, Paschen, S.A., Andreas Villunger, Eitz Ferrer, P., Drexler, Ingo, Eitz Ferrer, P;Potthoff, S;Kirschnek, S;Gasteiger, G;Kastenmuller, W;Ludwig, H;Paschen, SA;Villunger, A;Sutter, G;Drexler, I;Häcker, G   +45 more
core   +2 more sources

Susceptibility of different leukocyte cell types to Vaccinia virus infection

Virology Journal, 2004
Background Vaccinia virus, the prototype member of the family Poxviridae, was used extensively in the past as the Smallpox vaccine, and is currently considered as a candidate vector for new recombinant vaccines.
Sánchez-Puig Juana M, Sánchez Laura, Roy Garbiñe, Blasco Rafael   +3 more
doaj   +1 more source

The vaccinia virus K7 protein promotes histone methylation associated with heterochromatin formation. [PDF]

PLoS ONE, 2017
It has been well established that many vaccinia virus proteins suppress host antiviral pathways by targeting the transcription of antiviral proteins, thus evading the host innate immune system. However, whether viral proteins have an effect on the host's
Wondimagegnehu M Teferi, Megan A Desaulniers, Ryan S Noyce, Mira Shenouda, Brittany Umer, David H Evans   +5 more
doaj   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Modification of H-2 Antigenic Sites by Enzymatic Treatment Influences Virus-Specific Target Cell Lysis [PDF]

, 1976
Vaccinia virus-infected cells were treated enzymatically to remove H-2 antigenic sites. The effect of this procedure on virus-specific cell-mediated cytolysis (CMC) and virus-specific antibody-mediated cytolysis (AMC) was tested. Due to the inhibition of
Ertl, H C, Koszinowski, Ulrich H., Koszinowski, U H, Ertl, H.   +3 more
core   +1 more source

Severe Scrotal Cellulitis in a Young Man

JEADV Clinical Practice, EarlyView.
Hamad El Hajj, Vera Al Baaklini, Dima Jeha, Alfred Ammoury   +3 more
wiley   +1 more source

Fish Poxviruses on the Rise: Prospects for Aquatic Health

Journal of Fish Diseases, Volume 49, Issue 10, October 2026.
ABSTRACT Fish poxviruses are increasingly recognised as emerging pathogens of fish and should be considered in cases of unexplained gill or skin pathology. Carp edema virus (CEV), the causative agent of koi sleepy disease in common carp and koi (Cyprinus carpio), represents the first known example.
Mikolaj Adamek, Marek Matras, Oluwaseun Christianah Ojelade, Motohiko Sano, Mona C. Gjessing, Tomas Korytar, Alberto Falco, Krzysztof Rakus, Verena Jung‐Schroers, Andor Doszpoly   +9 more
wiley   +1 more source