Results 51 to 60 of about 44,247 (197)

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Ocular Vaccinia Infection in Dairy Worker, Brazil

Emerging Infectious Diseases, 2018
We studied a clinical case of vaccinia virus that caused an ocular manifestation in a dairy worker in Brazil. Biologic and molecular analyses identified a co-infection with 2 isolates from different Brazilian vaccinia virus phylogenetic groups.
Maurício Teixeira Lima, Graziele Pereira Oliveira, Felipe Lopes Assis, Danilo Bretas de Oliveira, Sidiner Mesquita Vaz, Giliane de Souza Trindade, Jônatas Santos Abrahão, Erna Geessien Kroon   +7 more
doaj   +1 more source

Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors. [PDF]

PLoS ONE, 2010
Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV.
Heather MacTavish, Jean-Simon Diallo, Baocheng Huang, Marianne Stanford, Fabrice Le Boeuf, Naomi De Silva, Julie Cox, John Graydon Simmons, Tanya Guimond, Theresa Falls, J Andrea McCart, Harry Atkins, Caroline Breitbach, David Kirn, Stephen Thorne, John C Bell   +15 more
doaj   +1 more source

Recurrent Respiratory Papillomatosis Foundation Position Statement on the Management of Adults With RRP

The Laryngoscope, EarlyView.
ABSTRACT Objective With regulatory approval of HPV‐specific immunotherapy for recurrent respiratory papillomatosis (RRP) and growing experience with systemic bevacizumab, a management algorithm incorporating these medical treatments is warranted. Data Sources and Methods RRP Foundation (RRPF) Key Opinion Leaders offer a proposed management algorithm ...
Simon R. Best, Aaron D. Friedman, Clark A. Rosen, Robert T. Sataloff, Laura A. Matrka, H. Steven Sims, David E. Rosow, Nabil F. Saba, David G. Lott, Adam M. Klein, Ted Mau, Milan R. Amin, Kathryn A. Wikenheiser‐Brokamp, Scott M. Norberg, Kim McClellan, Geoffrey D. Young, Clint T. Allen, on behalf of the Recurrent Respiratory Papillomatosis Foundation   +17 more
wiley   +1 more source

A novel high-throughput vaccinia virus neutralization assay and preexisting immunity in populations from different geographic regions in China. [PDF]

PLoS ONE, 2012
BACKGROUND: Pre-existing immunity to Vaccinia Tian Tan virus (VTT) resulting from a large vaccination campaign against smallpox prior to the early 1980s in China, has been a major issue for application of VTT-vector based vaccines.
Qiang Liu, Weijin Huang, Jianhui Nie, Rong Zhu, Dongying Gao, Aijing Song, Shufang Meng, Xuemei Xu, Youchun Wang   +8 more
doaj   +1 more source

Inclusion Bodies of the Vaccinia Virus.

Experimental Biology and Medicine, 1958
SummaryTwo kinds of inclusion bodies, “A” and “B” type, exist in tissues infected with ectromelia, fowl pox and vaccinia viruses. “B” type inclusion bodies of these 3 pox group viruses have almost the same morphological and cytochemical characters. The “A” type inclusion bodies of these viruses differ according to virus and host cell.
J, KAMAHORA, Y, SATO, S, KATO, K, HAGIWARA   +3 more
openaire   +2 more sources

The Expanding Landscape of Microbiota Medicine: Indications, Therapeutic Modalities, and the Path Towards Integrative Microbiome‐Targeting Healthcare

Microbiota Medicine Research, EarlyView.
ABSTRACT The growing recognition of the microbiome's role in human health has propelled the emergence of microbiota medicine—a new discipline integrating microbiology, multi‐omics, and clinical science. Advances in sequencing, data integration, and interventions such as fecal microbiota transplantation (FMT) have transitioned the field from ...
Min Dai, Yisha Lin, Renyou Gan, Xiaotao Shen, Shin Young Park, Sunjae Lee, Qi Su   +6 more
wiley   +1 more source

Compact, Synthetic, Vaccinia Virus Early/Late Promoter for Protein Expression

BioTechniques, 1997
Vaccinia virus, a member of the poxvirus family, is widely used as a mammalian cell expression vector. Vaccinia virus replicates in the cytoplasm and has its own transcriptional system, making it necessary to use viral promoters.
Sekhar Chakrabarti, Jerry R. Sisler, Bernard Moss   +2 more
doaj   +1 more source

Allergic airway disease in mice alters T and B cell responses during an acute respiratory poxvirus infection. [PDF]

PLoS ONE, 2013
Pulmonary viral infections can exacerbate or trigger the development of allergic airway diseases via multiple mechanisms depending upon the infectious agent.
Crystal C Walline, Sarita Sehra, Amanda J Fisher, Lynette M Guindon, Ian M Kratzke, Jessica B Montgomery, Kelsey P Lipking, Nicole L Glosson, Heather L Benson, George E Sandusky, David S Wilkes, Randy R Brutkiewicz, Mark H Kaplan, Janice S Blum   +13 more
doaj   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source