Results 31 to 40 of about 44,247 (197)

Purification of Vaccinia Virus

American Journal of Public Health and the Nations Health, 1934
THE success attained by chemists in preparing purified or concentrated extracts of tissue containing enzymes and other biological products has stimulated similar attempts upon the tissues of animals infected with filterable viruses.1 2 8 The virus of vaccinia has received considerable attention in this respect, due in part perhaps to the economy and ...
M, Schaeffer, H, Nalibow
openaire   +3 more sources

PCR-Based Method for the Introduction of Mutations in Genes Cloned and Expressed in Vaccinia Virus

BioTechniques, 1998
Vaccinia virus expression systems allow efficient expression of genes and facilitate functional studies of expressed proteins in cultured mammalian cells.
María del Mar Lorenzo, Rafael Blasco
doaj   +1 more source

Canine Adipose-Derived Mesenchymal Stem Cells (cAdMSCs) as a “Trojan Horse” in Vaccinia Virus Mediated Oncolytic Therapy against Canine Soft Tissue Sarcomas

Viruses, 2020
Several oncolytic viruses (OVs) including various human and canine adenoviruses, canine distemper virus, herpes-simplex virus, reovirus, and members of the poxvirus family, such as vaccinia virus and myxoma virus, have been successfully tested for canine
Ivan Petrov, Ivaylo Gentschev, Anna Vyalkova, Mohamed I. Elashry, Michele C. Klymiuk, Stefan Arnhold, Aladar A. Szalay   +6 more
doaj   +1 more source

Group 2 Vaccinia Virus, Brazil

Emerging Infectious Diseases, 2012
In 2011, vaccinia virus caused an outbreak of bovine vaccinia, affecting dairy cattle and dairy workers in Brazil. Genetic and phenotypic analyses identified this isolate as distinct from others recently identified, thereby reinforcing the hypothesis ...
Felipe Lopes Assis, Iara Apolinario Borges, Paulo César Peregrino Ferreira, Cláudio Antônio Bonjardim, Giliane de Souza Trindade, Zélia Inês Portela Lobato, Maria Isabel Maldonado Guedes, Vaz Mesquita, Erna Geessien Kroon, Jônatas Santos Abrahão   +9 more
doaj   +1 more source

Vaccinia virus proteolysis—a review [PDF]

Reviews in Medical Virology, 2006
AbstractIt is well known that viruses, as obligate intracellular parasites, must use their hosts' metabolic machinery in order to replicate their genomes and form infectious progeny virions. What is less well known are the details of how viruses make sure that once all the necessary proteins are made, that they assume the correct configuration at the ...
Chelsea M, Byrd, Dennis E, Hruby
openaire   +2 more sources

Evaluation of Monkeypox- and Vaccinia virus-neutralizing antibodies in human serum samples after vaccination and natural infection

Frontiers in Public Health, 2023
IntroductionIn early to mid-2022, an unexpected outbreak of Monkeypox virus infections occurred outside the African endemic regions. Vaccines originally developed in the past to protect against smallpox are one of the available countermeasures to prevent
Alessandro Manenti, Niccolò Solfanelli, Paolo Cantaloni, Livia Mazzini, Margherita Leonardi, Margherita Leonardi, Linda Benincasa, Giulia Piccini, Serena Marchi, Martina Boncioli, Chiara Spertilli Raffaelli, Danilo Tacconi, Giada Mattiuzzo, Otfried Kistner, Emanuele Montomoli, Emanuele Montomoli, Emanuele Montomoli, Claudia Maria Trombetta, Claudia Maria Trombetta   +18 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Studies on the Structure of Vaccinia Virus [PDF]

Journal of General Microbiology, 1964
SUMMARY: Vaccinia virus has been examined with the electron microscope by several techniques in conjunction with experimental modifications of structure. Negative staining revealed that over 80% of the virus in highly purified preparations were particles which appeared to have a beaded surface like a mulberry and were termed M forms.
J C, WESTWOOD, W J, HARRIS, H T, ZWARTOUW, D H, TITMUSS, G, APPLEYARD   +4 more
openaire   +2 more sources

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Generation of recombinant mAbs to vaccinia virus displaying high affinity and potent neutralization

Microbiology Spectrum, 2023
Members of the Orthopoxvirus genus can cause severe infections in humans. Global vaccination against smallpox, caused by the variola virus, resulted in the eradication of the disease in 1980.
Tal Noy-Porat, Hadas Tamir, Ron Alcalay, Ronit Rosenfeld, Eyal Epstein, Lilach Cherry, Hagit Achdout, Noam Erez, Boaz Politi, Yfat Yahalom-Ronen, Shay Weiss, Sharon Melamed, Tomer Israely, Ohad Mazor, Nir Paran, Efi Makdasi   +15 more
doaj   +1 more source