Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells. [PDF]
PLoS ONE, 2015 Vaccinia virus is a large, enveloped virus of the poxvirus family. It has broad tropism and typically virus replication culminates in accumulation and lytic release of intracellular mature virus (IMV), the most abundant form of infectious virus, as well ...
Suvi Parviainen +7 more
doaj +1 more source
MethodsX, 2020 Vaccinia virus is capable of replicating in a wide range of vertebrate animal cells. However, deletion of the two virus host range genes, E3L and K3L, would render replication of the virus abortive in all the cell types tested, except the cells with ...
Jingxin Cao +3 more
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Generation of recombinant vaccinia virus and analysis of virus-induced cell death
STAR Protocols, 2021 Summary: Vaccinia virus is a large double-stranded DNA virus that is widely used to express foreign genes from different origins. We generated recombinant vaccinia virus that expresses a viral inhibitor to examine its effect on virus-induced necroptosis.
Zhijun Liu +2 more
doaj +1 more source
Interactions between vaccinia virus and sensitized macrophages in vitro [PDF]
, 1975 The action of peritoneal exudate cells (PEC) from normal and vaccinia virus infected mice on infectious vaccinia virus particles was investigatedin vitro. PEC from immune mice showed a significantly higher infectivity titre reduction (virus clearance, VC)
Kruse, F. +5 more
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Reemergence of Vaccinia Virus during Zoonotic Outbreak, Pará State, Brazil
Emerging Infectious Diseases, 2013 In 2010, vaccinia virus caused an outbreak of bovine vaccinia that affected dairy cattle and rural workers in Pará State, Brazil. Genetic analyses identified the virus as distinct from BeAn58058 vaccinia virus (identified in 1960s) and from smallpox ...
Felipe L. de Assis +9 more
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A new inhibitor of apoptosis from vaccinia virus and eukaryotes. [PDF]
, 2007 A new apoptosis inhibitor is described from vaccinia virus, camelpox virus, and eukaryotic cells. The inhibitor is a hydrophobic, multiple transmembrane protein that is resident in the Golgi and is named GAAP (Golgi anti-apoptotic protein).
Hollinshead, M +19 more
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Effect of the deletion of genes encoding proteins of the extracellular virion form of vaccinia virus on vaccine immunogenicity and protective effectiveness in the mouse model. [PDF]
PLoS ONE, 2013 Antibodies to both infectious forms of vaccinia virus, the mature virion (MV) and the enveloped virion (EV), as well as cell-mediated immune response appear to be important for protection against smallpox.
Clement A Meseda +5 more
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Pre-clinical efficacy and safety of experimental vaccines based on non-replicating vaccinia vectors against yellow fever. [PDF]
PLoS ONE, 2011 BACKGROUND: Currently existing yellow fever (YF) vaccines are based on the live attenuated yellow fever virus 17D strain (YFV-17D). Although, a good safety profile was historically attributed to the 17D vaccine, serious adverse events have been reported,
Birgit Schäfer +8 more
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Molecular Therapy: Oncolytics, 2017 Multiple myeloma is a malignancy of plasma cells of the bone marrow. Although the prognosis is variable, no curative therapy has been defined. Vaccinia virus infects cancer cells and kills such cells in a variety of ways.
Muneyoshi Futami +5 more
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Can vaccinia virus be replaced by MVA virus for testing virucidal activity of chemical disinfectants? [PDF]
, 2010 Background: Vaccinia virus strain Lister Elstree (VACV) is a test virus in the DVV/RKI guidelines as representative of the stable enveloped viruses.
Jochen Steinmann +8 more
core +2 more sources