Results 11 to 20 of about 1,158,425 (219)
Vaccinia virus replication is not affected by APOBEC3 family members [PDF]
Virology Journal, 2006 Background The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. It facilitates the deamination of the cytosine residues in the single stranded cDNA intermediate during early steps of retroviral infection.
Sutter Gerd +5 more
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Vaccinia virus-based vector against infectious diseases and tumors
Human Vaccines & Immunotherapeutics, 2021 Vaccinia virus was used to prevent smallpox. After the World Health Organization declared smallpox extinct, vaccinia virus has been explored for the development of vaccines against a variety of infectious diseases.
Ziling Zhang +5 more
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An Update on the Known Host Range of the Brazilian Vaccinia Virus: An Outbreak in Buffalo Calves
Frontiers in Microbiology, 2019 Even nearly forty years after the eradication of smallpox, members of the Poxviridae family continue to be the focus of an increasing number of studies.
Mauricio Teixeira Lima +7 more
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Structure and functional analyses of vaccinia virus J5 protein reveal distinct determinants for entry-fusion complex assembly and activation [PDF]
Journal of VirologyVaccinia virus enters host cells through a multi-component entry-fusion complex (EFC) that is structurally distinct from canonical viral fusion systems.
Hsiao-Jung Chiu +6 more
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Passatempo Virus, a Vaccinia Virus Strain, Brazil
Emerging Infectious Diseases, 2005 Passatempo virus was isolated during a zoonotic outbreak. Biologic features and molecular characterization of hemagglutinin, thymidine kinase, and vaccinia growth factor genes suggested a vaccinia virus infection, which strengthens the idea of the ...
Juliana A. Leite +11 more
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Arming vaccinia virus for pancreatic cancer oncolytic virotherapy [PDF]
, 2011 PhDVaccinia virus is a 250-300nm enveloped DNA virus from the poxvirus family and is used as a vector for oncolytic viral gene therapy. No unique cell surface receptor has been identified for Vaccinia virus and the reasons for its tropism for cancer ...
Hiley, Crispin
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Microbiology Spectrum, 2023 In addition to the 3′-poly(A) tail, vaccinia virus mRNAs synthesized after viral DNA replication (post-replicative mRNAs) possess a 5′-poly(A) leader that confers a translational advantage in virally infected cells.
Pragyesh Dhungel +2 more
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Attenuation of Vaccinia Virus [PDF]
Acta Naturae, 2015 Since 1980, in the post-smallpox vaccination era the human population has become increasingly susceptible compared to a generation ago to not only the variola (smallpox) virus, but also other zoonotic orthopoxviruses. The need for safer vaccines against orthopoxviruses is even greater now.
YAKUBITSKIY S.N. +3 more
openaire +3 more sources
Vaccinia E5 is a major inhibitor of the DNA sensor cGAS
Nature Communications, 2023 The DNA sensor cyclic GMP-AMP synthase (cGAS) is critical in host antiviral immunity. Vaccinia virus (VACV) is a large cytoplasmic DNA virus that belongs to the poxvirus family.
Ning Yang +11 more
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Biomedicines, 2020 As a live biologic agent, oncolytic vaccinia virus has the ability to target and selectively amplify at tumor sites. We have previously reported that deletion of thymidine kinase and ribonucleotide reductase genes in vaccinia virus can increase the ...
Franck Gallardo +14 more
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