Results 11 to 20 of about 1,083,137 (225)
Vaccinia virus replication is not affected by APOBEC3 family members [PDF]
Virology Journal, 2006 Background The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. It facilitates the deamination of the cytosine residues in the single stranded cDNA intermediate during early steps of retroviral infection.
Sutter Gerd +5 more
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Structure and functional analyses of vaccinia virus J5 protein reveal distinct determinants for entry-fusion complex assembly and activation [PDF]
Journal of VirologyVaccinia virus enters host cells through a multi-component entry-fusion complex (EFC) that is structurally distinct from canonical viral fusion systems.
Hsiao-Jung Chiu +6 more
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Arming vaccinia virus for pancreatic cancer oncolytic virotherapy [PDF]
, 2011 PhDVaccinia virus is a 250-300nm enveloped DNA virus from the poxvirus family and is used as a vector for oncolytic viral gene therapy. No unique cell surface receptor has been identified for Vaccinia virus and the reasons for its tropism for cancer ...
Hiley, Crispin
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Microbiology Spectrum, 2023 In addition to the 3′-poly(A) tail, vaccinia virus mRNAs synthesized after viral DNA replication (post-replicative mRNAs) possess a 5′-poly(A) leader that confers a translational advantage in virally infected cells.
Pragyesh Dhungel +2 more
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Attenuation of Vaccinia Virus [PDF]
Acta Naturae, 2015 Since 1980, in the post-smallpox vaccination era the human population has become increasingly susceptible compared to a generation ago to not only the variola (smallpox) virus, but also other zoonotic orthopoxviruses. The need for safer vaccines against orthopoxviruses is even greater now.
YAKUBITSKIY S.N. +3 more
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Vaccinia virus-based vector against infectious diseases and tumors
Human Vaccines & Immunotherapeutics, 2021 Vaccinia virus was used to prevent smallpox. After the World Health Organization declared smallpox extinct, vaccinia virus has been explored for the development of vaccines against a variety of infectious diseases.
Ziling Zhang +5 more
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Biomedicines, 2020 As a live biologic agent, oncolytic vaccinia virus has the ability to target and selectively amplify at tumor sites. We have previously reported that deletion of thymidine kinase and ribonucleotide reductase genes in vaccinia virus can increase the ...
Franck Gallardo +14 more
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Vaccinia E5 is a major inhibitor of the DNA sensor cGAS
Nature Communications, 2023 The DNA sensor cyclic GMP-AMP synthase (cGAS) is critical in host antiviral immunity. Vaccinia virus (VACV) is a large cytoplasmic DNA virus that belongs to the poxvirus family.
Ning Yang +11 more
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Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells. [PDF]
PLoS ONE, 2015 Vaccinia virus is a large, enveloped virus of the poxvirus family. It has broad tropism and typically virus replication culminates in accumulation and lytic release of intracellular mature virus (IMV), the most abundant form of infectious virus, as well ...
Suvi Parviainen +7 more
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MethodsX, 2020 Vaccinia virus is capable of replicating in a wide range of vertebrate animal cells. However, deletion of the two virus host range genes, E3L and K3L, would render replication of the virus abortive in all the cell types tested, except the cells with ...
Jingxin Cao +3 more
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