Vaccinia Virus Induces Programmed Necrosis in Ovarian Cancer Cells
Molecular Therapy, 2013 The mechanisms by which oncolytic vaccinia virus induces tumor cell death are poorly understood. We have evaluated cell death pathways following infection of ovarian cancer cells with both wild-type and thymidine kinase-deleted (dTK) Lister strain ...
L. Whilding +5 more
semanticscholar +1 more source
Virology Journal, 2013 BackgroundAnimal-borne orthopoxviruses, like monkeypox, vaccinia and the closely related cowpox virus, are all capable of causing zoonotic infections in humans, representing a potential threat to human health.
D. Bourquain +2 more
semanticscholar +1 more source
The Conditions of Primary Infection Define the Load of Latent Viral Genome in Organs and the Risk of Recurrent Cytomegalovirus Disease [PDF]
, 1994 Recurrence of cytomegalovirus (CMV) from latency is a frequent cause of disease in immunocompromised patients. To date, there is no explanation for the diversity in the clinical manifestations.
Balthesen, Monika +5 more
core +4 more sources
Primary Human B Cells at Different Differentiation and Maturation Stages Exhibit Distinct Susceptibilities to Vaccinia Virus Binding and Infection [PDF]
, 2019 Nicole Shepherd +4 more
openalex +1 more source
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. [PDF]
, 2010 Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18. We elucidate here how host macrophages recognize F.
Alnemri, Emad S +12 more
core +3 more sources
Oncolytic virus therapy: A new era of cancer treatment at dawn
Cancer Science, 2016 Oncolytic virus therapy is perhaps the next major breakthrough in cancer treatment following the success in immunotherapy using immune checkpoint inhibitors.
H. Fukuhara, Y. Ino, T. Todo
semanticscholar +1 more source
A yeast protein phosphatase related to the vaccinia virus VH1 phosphatase is induced by nitrogen starvation. [PDF]
, 1992 Kun‐Liang Guan +5 more
openalex +1 more source
CENTRIFUGE EXPERIMENTS WITH THE VIRUS OF VACCINIA [PDF]
Journal of Experimental Medicine, 1930 Centrifuge experiments have been carried out with cell-free, active filtrates of vaccinia virus. The experiments have shown that the virus can be concentrated by this method, even in filtrates which have been subjected to prolonged preliminary centrifugation to throw down any inert particles which may have been present in the original filtrate.
openaire +2 more sources
Protein of macaques against infection with simian type D retrovirus (SRV-1) by immunization with recombinant vaccinia virus expressing the envelope glycoproteins of either SRV-1 or Mason-Pfizer monkey virus (SRV-3) [PDF]
, 1992 B A Brody +5 more
openalex +1 more source
Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors. [PDF]
, 2009 Protein kinase PKR (also known as EIF2AK2) is activated during viral infection and phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2), leading to inhibition of translation and viral replication. We report fast evolution
Dever, Thomas E +4 more
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