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Vaccinia virus immune evasion

Immunological Reviews, 1997
SummaryVaccinia virus and other poxviruses express a wide variety of proteins which are nonessential for virus replication in culture but help the virus to evade the host response to infection. Examples include proteins which oppose apoptosis. Synthesise steroids, capture chemokines, counteract complement, interfere with interferon and intercept ...
Antonio Alcami   +4 more
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Purification of the Virus of Vaccinia

Journal of Infectious Diseases, 1932
A great deal of work has been done during the past few years to separate the virus of vaccinia from cells and extraneous material. Ward and Tang,1 Ward,2 and Yaoi and Kasai3 filtered the virus. Bland4 filtered and centrifugated it; Tang5 centrifugated it, Douglas and Smith,6 and Lepine 7 carried out cataphoresis experiments, while Yaoi and Kasai 8 ...
L. B. Morgan, C. A. Behrens
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Vaccinia Virus Expression Vectors

Journal of General Virology, 1986
Introduction. Recombinant DNA technology has made possible the expression of heterologous genes in a variety of animal viruses (for review, see Rigby, 1983). The availability of a wide variety of animal virus vectors enables a foreign gene to be expressed in different cell types, at different levels and with different consequences for the host cell ...
Geoffrey L. Smith, M Mackett
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Vaccinia Virus (Poxviridae)

Encyclopedia of Virology, 2021
Yan Xiang, Rebecca K. Lane
semanticscholar   +1 more source

The wet preservation of vaccinia virus

Archiv f�r die gesamte Virusforschung, 1966
Buffered glycerol was shown to be an efficient preservation medium for vaccinia virus, but under the described experimental conditions it was not superior to serum, glycerol-serum, glycerol-broth or fortified Earle's saline in respect of preservative qualities, although it was in respect of its defined chemical composition.
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Topography of vaccinia virus DNA

Virology, 1977
Abstract Contour length measurements in an electron microscope of vaccinia genomes released from virions by lysis in Sarkosyl and 2-mercaptoethanol at 4° on the surface of gradients, followed by sedimentation into the gradients to remove proteins, showed that the linear, double-stranded (ds) viral DNA molecules prepared in this way, had a MW of 132 ...
Mariano Esteban   +2 more
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An Update on the Vaccinia Virus Genome

Virology, 1993
This communication is intended as a single source update of the initial report (Goebel et al., 1990a,b) which described the complete DNA sequence of the vaccinia virus genome. We have integrated published information as well as unpublished data. Our understanding of the complexities of the genetic functional organization of poxviruses is increasing at ...
Gerard P. Johnson   +2 more
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Vaccinia virus E2

, 2021
W. Gao, C. Gao, S. Graham
semanticscholar   +1 more source

The Insertion of DNA into Vaccinia Virus

Science, 1976
Cells infected with vaccinia virus in the presence of hydroxyurea (HU), which blocks DNA replication, were examined in thin sections by electron microscopy at intervals after removal of HU. Dense, fibrillar material was observed at the orifice formed just before closure of the membrane constituting the envelope of the immature form of the virus.
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Vaccinia Virus as an Expression Vector

2003
Vaccinia virus (Vv) is a member of the genus Orthopoxvirus, one of seven genera included in the family Poxviridae. Most of these viruses infect vertebrates (Orthopoxvirus, Avipoxvirus, Capripoxvirus, Leporipoxvirus, Suipoxvirus, and Parapoxvirus), but one genus, Entomopoxvirus, infects insects.
Antonio Talavera, Javier M. Rodriguez
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