Results 71 to 80 of about 23,444 (214)

Design and Immune Profile of Multi-Epitope Synthetic Antigen Vaccine Against SARS-CoV-2: An In Silico and In Vivo Approach

Vaccines
Background: The rapid advancement of the pandemic caused by SARS-CoV-2 and its variants reinforced the importance of developing easy-to-edit vaccines with fast production, such as multi-epitope DNA vaccines.
Maria da Conceição Viana Invenção, Larissa Silva de Macêdo, Ingrid Andrêssa de Moura, Lucas Alexandre Barbosa de Oliveira Santos, Benigno Cristofer Flores Espinoza, Samara Sousa de Pinho, Lígia Rosa Sales Leal, Daffany Luana dos Santos, Bianca de França São Marcos, Carolina Elsztein, Georon Ferreira de Sousa, Guilherme Antonio de Souza-Silva, Bárbara Rafaela da Silva Barros, Leonardo Carvalho de Oliveira Cruz, Julliano Matheus de Lima Maux, Jacinto da Costa Silva Neto, Cristiane Moutinho Lagos de Melo, Anna Jéssica Duarte Silva, Marcus Vinicius de Aragão Batista, Antonio Carlos de Freitas   +19 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, Volume 16, Issue 9, Page 1813-1824, September 2026.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Advancing vaccinology in India [PDF]

Expert Review of Vaccines, 2012
India's inaugural Advanced Vaccinology Course, hosted by the Child Health Foundation and the International Clinical Epidemiology Network, attracted approximately 55 EPI managers and privately-practicing physicians from across the country. The comprehensive course provided training in epidemiology, disease surveillance, and vaccine safety and regulation.
openaire   +2 more sources

New Approaches to Vaccinology Made Possible by Advances in Next Generation Sequencing, Bioinformatics and Protein Modeling

, 2021
Vaccines can be powerful tools, but for some diseases, safe and effective vaccines have been elusive. New developments in nucleic acid sequencing, bioinformatics, and protein modeling are facilitating the discovery of previously unknown antigens through ...
Cypriana Swiderski, Amelia R. Woolums
core   +1 more source

From Identification to Enzymatic Activity Profiling: Comprehensive Characterization of BloCAβ, a Probiotic β‐Carbonic Anhydrase From Bifidobacterium longum

Archiv der Pharmazie, Volume 359, Issue 9, September 2026.
Production and biochemical characterization of a new β‐carbonic anhydrase from the probiotic Bifidobacterium longum, one of the main players of human gut microbiota. ABSTRACT The microbiota comprises communities of microorganisms that establish complex relationships with the host and play key roles in physiology, metabolism, and immunity.
Simone Giovannuzzi, Andrea Ammara, Simone Carradori, Viviana De Luca, Marialucia Gallorini, Damiano Iacovozzi, Amelia Cataldi, Ilaria D'Agostino, Davide Moi, Valentina Onnis, Claudiu T. Supuran, Clemente Capasso   +11 more
wiley   +1 more source

Review of ”Bioinformatics for vaccinology“ edited by Darren R. Flower [PDF]

, 2009
Book review of "Bioinformatics for vaccinology" edited by Darren R. Flower.
Hong-Seog Park, Park Hong-Seog, Kim Dae-Won, Hong-Seog Park, Dae-Won Kim   +4 more
core   +1 more source

Bacterial Lysis Observation Over Time Assay (BLOTS) for High‐Throughput Isolation, Sequencing, and Characterization of Bacteriophages

Current Protocols, Volume 6, Issue 9, September 2026.
Abstract Phages remain severely under‐sampled, largely due to the limitations of current isolation methods, which are labor‐intensive, low‐throughput, and often restricted to a narrow set of bacterial hosts. To address this gap, we developed a robust and scalable field‐to‐genome workflow that leverages laboratory automation to screen environmental ...
Sean Jia Le Pang, Soon Keong Wee, Bobby Guo Wei Lee, Odelia Yap, Eric Peng Huat Yap   +4 more
wiley   +1 more source

Functional antibodies as immunological endpoints to evaluate protective immunity against Shigella

Human Vaccines & Immunotherapeutics, 2020
The development, clinical advancement and licensure of vaccines, and monitoring of vaccine effectiveness could be expedited and simplified by the ability to measure immunological endpoints that can predict a favorable clinical outcome.
Esther Ndungo, Marcela F. Pasetti
doaj   +1 more source

Use of Dried Blood Spots for Identifying Hepatitis E Infections in an Outbreak Setting

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Accurate and accessible diagnostics for hepatitis E virus (HEV) are essential for outbreak preparedness and surveillance, particularly in low‐resource settings. Dried blood spots (DBS) are a scalable alternative to serum, but their diagnostic performance for HEV remains poorly characterised.
Catia Alvarez, Robin Nesbitt, Kinya Vincent Asilaza, Pascale Sattonnet‐Roche, Joseph Wamala, Shimul Das, Melat Haile, Monica Rull, Etienne Gignoux, Manuel Albela, John Rumunu, Isabella Eckerle, Iza Ciglenecki, Andrew S. Azman, Benjamin Meyer   +14 more
wiley   +1 more source

Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi, Shengbin Liu, Danni Dai, Shanhui Jiang, Tingchen Tian, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Fang Liu, Xue Tang, Xin Jiang, Xiangrong Song   +11 more
wiley   +1 more source