Results 41 to 50 of about 2,250 (114)
Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.Abstract INTRODUCTION Faulty autolysosome acidification leads to dystrophic neurites—an early event propelling Alzheimer's disease (AD) progression—yet the underlying mechanism remains elusive. METHODS To elucidate the physiological functions of neuronal ATP citrate lyase (ACLY) expression, its impact on amyloid beta (Aβ) pathology, and molecular ...
Anlan Lin +10 more
wiley +1 more source
Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy
Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan +5 more
wiley +1 more source
Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro +5 more
wiley +1 more source
Plant Direct, Volume 9, Issue 11, November 2025.ABSTRACT SnRK1 is an evolutionarily conserved protein kinase belonging to the SNF1/AMPK family of protein kinases that is central to adjusting growth in response to the energy status. Numerous studies have shown adaptive and developmental roles of SnRK1, but the understanding of the SnRK1 signaling network in monocots is limited.
Maria C. Faria‐Bates +3 more
wiley +1 more source
Cryo‐EM single‐particle analysis expanding towards increasingly native samples
Acta Crystallographica Section D, Volume 81, Issue 11, Page 587-597, November 2025.Cryo‐EM single‐particle analysis has revolutionized structural biology by allowing high‐resolution analysis of large molecular assemblies that are not amenable to crystallography or NMR. Combination of this technology with innovative sample‐preparation protocols further expands the range of potential targets.The explosion of cryo‐electron microscopy ...
Jonas Moecking, Tzviya Zeev-Ben-Mordehai
wiley +1 more source
The FASEB Journal, Volume 39, Issue 20, 31 October 2025.Drug‐induced gingival overgrowth involves dysregulation of intracellular collagen degradation. The mechanisms that are involved in the regulation of lysosomal collagenolytic activity are poorly understood. Here, we focus on how cathepsins, Rabs, and V‐ATPases regulate intracellular collagen degradation and, in particular, the vesicular trafficking and ...
Wing Hei Wong +3 more
wiley +1 more source
The Journal of biological chemistry, 2006 Vacuolar proton-translocating ATPase pumps consist of two domains, V(1) and V(o). Subunit d is a component of V(o) located in a central stalk that rotates during catalysis. By generating mutations, we showed that subunit d couples ATP hydrolysis and proton transport.
Margaret A, Owegi +13 more
openaire +1 more source
Vacuolar proton-translocating ATPase is required for antifungal resistance and virulence of Candida glabrata長崎大学学位論文 [学位記番号]博（医歯薬）甲第1170号 [学位授与年月日]令和元年6月5日 (2019-06-05)
openaire +1 more source
Bone-in-bone and sandwich vertebrae in a 6-month-old infant with genetically confirmed fatal osteopetrosis: A case report. [PDF]
Medicine (Baltimore)Hou F, Zhang J.
europepmc +1 more source
V-ATPase Disassembly at the Yeast Lysosome-Like Vacuole Is a Phenotypic Driver of Lysosome Dysfunction in Replicative Aging. [PDF]
Aging CellHashmi F, Kane PM.
europepmc +1 more source