Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Microwave Vacuum Drying Characteristics of Noni Fruits (Morinda Citrifolia L.) and Their Effects on Scopoletin Content [PDF]
The main objective of this study was to investigate microwave-vacuum drying characteristics of Morinda citrifolia fruit slices and drying effects on Scopoletin content.
Asr, Mina Habibi
core
Electrostatically driven vacuum-encapsulated polysilicon resonators part I. design and fabrication [PDF]
Basic design issues and a fabrication process based on surface-micromachining techniques for electrostatically driven vacuum-encapsulated polysilicon resonators are presented.
Legtenberg, Rob, Tilmans, Harrie A.C.
core +4 more sources
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Научно–практические основы энергосберегающего термовакуумного процесса сушки дисперсных материалов [PDF]
Проведена научно-практические исследования энергосберегающего метода термовакуумного процесса сушки дисперсных материалов, который продемонстрирован на примере сушки отходов деревообрабатывающей промышленностиHeld a scientific-practical research of ...
Кутовой, В. А. +2 more
core +1 more source
Pengeringan Beku Vakum Bengkuang dengan Memanfaatkan Panas Buang Kondensor untuk Proses Sublimasi [PDF]
Vacuum Freeze Drying is one of the best ways of drying products as freeze drying vacuum drying or preserving materials without a change in physical and chemical properties of materials. This study was a continuation of previous studies that
Brama, J. (Jaka), Martin, A. (Awaludin)
core
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
The Effects of Freeze-Drying on the Strength Characteristics of Naturally Aged Book Papers [PDF]
Libraries occasionally have water main breaks, fires and floods. These disasters cause considerable water damage to thousands of books. Books that are left wet on the shelves will grow mold.
Sarokin, Steven D.
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source

