Results 41 to 50 of about 2,391,391 (303)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The effect of refrigeration and room temperature storage conditions on the physico-chemical characteristics of hybrid and freeze-dried blueberries

Journal of Agriculture and Food Research
In order to preserve the nutritional properties of fruits after dehydration, it is necessary to use appropriate storage methods. The traditional freeze-dried and combination-dried i. e. vacuum pre- and freeze post-dried, freeze pre- and vacuum post-dried,
Tamás Antal
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Drying Characteristics of Moutan Cortex by Rotary Wheel Microwave Vacuum Drying and Its Influence on Quality

Agriculture
To enhance the quality of Moutan Cortex for medicinal purposes, this study was conducted to analyze the impact of rotary microwave vacuum drying on its drying characteristics and overall quality. Experimental variables including drying temperature, rotor
Jianwei Shang, Guojun Ma, Fangxin Wan, Zepeng Zang, Yanrui Xu, Qian Zhang, Tongxun Wang, Xiaopeng Huang   +7 more
doaj   +1 more source

Influence of vacuum microwave drying parameters on the physicochemical properties of red beetroots

Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького. Серія: Харчові технології, 2021
In recent years, the consumption of red beetroots has increased significantly due to its good taste, high nutritional value and abundant active compounds. Red beetroot is prone to spoilage due to its high moisture content, making it perishable.
Yan Liu, Sergey Sabadash, Dan Gao, Feifei Shang, Zhenhua Duan   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Effect of Different Drying Processes on the Quality of Edible Bird's Nest

Shipin gongye ke-ji, 2022
In this experiment, the effects of hot air drying, microwave drying, vacuum freeze drying and supercritical CO2 drying on the quality of edible bird's nests were investigated by comparing and analyzing the sensory quality, drying rate, rise times, color,
Longwei FU, Jianmei LIAN, Shuxian YE, Qunyan FAN   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Effects of Different Drying Methods on The Quality of Dried Yellow Peach Slices

Shipin gongye ke-ji, 2023
The aim of this study was to investigate the effects of different drying methods on the quality of dried yellow peach slices. Yellow peach slices were used as the research object, and vacuum freeze-drying (FD) and FD combined with microwave vacuum drying
Xiaofan XING, Haonan LIU, Fei YAO, Changhong LIU, Lei ZHENG   +4 more
doaj   +1 more source

Effect of multi-mode dual-frequency ultrasound pretreatment on the vacuum freeze-drying process and quality attributes of the strawberry slices

Ultrasonics sonochemistry, 2021
Highlights • Ultrasound osmotic pretreatment improved vacuum freeze-drying of strawberry slices.• Dual-frequency ultrasound shortened drying time more than single-frequency.• Dual-frequency ultrasound in sequential mode exhibited the best quality ...
Baoguo Xu, Jianan Chen, Essodézam Sylvain Tiliwa, Weiqiang Yan, S. M. Roknul Azam, Jun Yuan, Benxi Wei, Cunshan Zhou, Haile Ma   +8 more
semanticscholar   +1 more source