Does monthly self-management of vaginal ring pessaries reduce the rate of adverse events? A clinical audit [PDF]
European Journal of Obstetrics & Gynecology and Reproductive Biology: X, 2022 Objective: To determine the rate of adverse events (AE) in women who self-manage their vaginal ring pessary on a monthly basis. We hypothesised that the AE rate would be lower compared to previously published traditional management protocols.
Kate H. Moore +4 more
doaj +2 more sources
Rationale and Safety Assessment of a Novel Intravaginal Drug-Delivery System with Sustained DL-Lactic Acid Release, Intended for Long-Term Protection of the Vaginal Microbiome. [PDF]
PLoS ONE, 2016 Bacterial vaginosis is a prevalent state of dysbiosis of the vaginal microbiota with wide-ranging impact on human reproductive health. Based on recent insights in community ecology of the vaginal microbiome, we hypothesize that sustained vaginal DL ...
Hans Verstraelen +2 more
doaj +9 more sources
Participant experiences with a multipurpose vaginal ring for HIV and pregnancy prevention during a phase 1 clinical trial: learning from users to improve acceptability [PDF]
Frontiers in Reproductive Health, 2023 IntroductionWith high concurrent global rates of HIV incidence and unintended pregnancy, there is a need to provide options beyond condoms to enable users to simultaneously prevent HIV acquisition and pregnancy.
Mary Kate Shapley-Quinn +11 more
doaj +2 more sources
The Vaginal Microbiota, Bacterial Biofilms and Polymeric Drug-Releasing Vaginal Rings [PDF]
Pharmaceutics, 2021 The diversity and dynamics of the microbial species populating the human vagina are increasingly understood to play a pivotal role in vaginal health. However, our knowledge about the potential interactions between the vaginal microbiota and vaginally ...
Louise Carson +6 more
doaj +5 more sources
Advances in contraception: vaginal contraceptive rings
Therapeutic Advances in Reproductive Health, 2023 The vaginal contraceptive ring is very effective and user dependent. In this article, we will discuss the different types of vaginal contraceptive rings, namely, the etonogestrel/ethinyl estradiol (ENG/EE) ring (NuvaRing, Merck, Rahway, NJ, USA) and the ...
Sara Al-Haddad +2 more
doaj +3 more sources
Self-reported removal and expulsion of the dapivirine vaginal ring: qualitative reports from female ring users and their male partners in the Ring Study (IPM 027) [PDF]
BMC Public HealthBackground/aims The dapivirine vaginal ring is a self-administered, women-initiated, discreet, long-acting HIV-1 prevention option for women. It was found to be safe and effective in healthy HIV-negative women who adhered to product use instructions, and
Cecilia Milford +6 more
doaj +2 more sources
Preferred product attributes of a multipurpose vaginal ring: Findings from a phase 1 trial [PDF]
Frontiers in Reproductive Health, 2023 IntroductionMost women face multiple and co-occurring risks from unwanted pregnancy, human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs) at some point during their lifetime. While a range of contraceptive methods exist and
Elizabeth E. Tolley +4 more
doaj +2 more sources
Acceptability of a dapivirine levonorgestrel vaginal ring in two Phase 1 trials (MTN-030/IPM 041 and MTN-044/IPM 053/CCN019): Implications for multipurpose prevention technology development. [PDF]
PLoS ONEEnd-user feedback early in product development is important for optimizing multipurpose prevention technologies for HIV and pregnancy prevention. We evaluated the acceptability of the 90-day dapivirine levonorgestrel ring (DPV-LNG ring) used for 14 days ...
Barbara A Friedland +22 more
doaj +2 more sources
High adherence to intermittent and continuous use of a contraceptive vaginal ring among women in a randomized controlled trial in Kigali, Rwanda [PDF]
Frontiers in Global Women's HealthBackgroundThe introduction of female-initiated drug-delivery methods, including vaginal rings, have proven to be a promising avenue to address sexually transmitted infections and unintended pregnancies, which disproportionally affects women and girls in ...
Evelyne Kestelyn +15 more
doaj +2 more sources
Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel [PDF]
International Journal of Pharmaceutics: X, 2021 A dapivirine-releasing silicone elastomer vaginal ring for reducing women's risk of HIV acquisition has recently been approved. A next-generation multipurpose vaginal ring releasing dapivirine and levonorgestrel is currently in development, offering ...
Yahya H. Dallal Bashi +13 more
doaj +2 more sources