Results 21 to 30 of about 1,435,723 (230)

Efficacy and Action of the Dapivirine Vaginal Ring as Understood by Women Participating in an Open Label Extension Study. [PDF]

AIDS Behav, 2023
Naidoo K, T ME, Katz AW, Morgan G, Krishnaveni R, Lydia ST, Sarita N, Leila ME.   +7 more
europepmc   +2 more sources

Introducing the Dapivirine Vaginal Ring in Sub-Saharan Africa: What Can We Learn from Oral PrEP? [PDF]

Curr HIV/AIDS Rep, 2021
Clinical trials have found that the dapivirine vaginal ring (DVR) is safe to use and effective at reducing women’s risk of acquiring HIV infection. As countries prepare for the introduction of this novel long-acting, woman-controlled prevention method ...
Bhavaraju N, Shears K, Schwartz K, Mullick S, Jeckonia P, Murungu J, Persaud U, Vij A, Torjesen K.   +8 more
europepmc   +2 more sources

DELIVER: A Safety Study of a Dapivirine Vaginal Ring and Oral PrEP for the Prevention of HIV During Pregnancy. [PDF]

J Acquir Immune Defic Syndr, 2023
Supplemental Digital Content is Available in the Text. Background: Pregnancy represents a period of high HIV acquisition risk. Safety data for the monthly dapivirine vaginal ring (DVR) during pregnancy are limited.
Bunge K, Balkus JE, Fairlie L, Mayo AJ, Nakabiito C, Mgodi N, Gadama L, Matrimbira M, Chappell CA, Piper J, Chakhtoura N, Szydlo DW, Richardson B, Hillier SL.   +13 more
europepmc   +2 more sources

Contraceptive rings promote vaginal lactobacilli in a high bacterial vaginosis prevalence population: A randomised, open-label longitudinal study in Rwandan women. [PDF]

PLoS ONE, 2018
BACKGROUND:Hormonal contraception has been associated with a reduced risk of vaginal dysbiosis, which in turn has been associated with reduced prevalence of sexually transmitted infections (STIs), including HIV.
Tania Crucitti, Liselotte Hardy, Janneke van de Wijgert, Stephen Agaba, Jozefien Buyze, Evelyne Kestelyn, Thérèse Delvaux, Lambert Mwambarangwe, Irith De Baetselier, Vicky Jespers, Ring Plus study group   +10 more
doaj   +1 more source

Safety of a silicone elastomer vaginal ring as potential microbicide delivery method in African women: A Phase 1 randomized trial. [PDF]

PLoS ONE, 2018
Women in sub-Saharan Africa are in urgent need of female-initiated human immunodeficiency virus (HIV) preventative methods. Vaginal rings are one dosage form in development for delivery of HIV microbicides.
Annaléne Nel, Janine Martins, Linda-Gail Bekker, Gita Ramjee, Gileard Masenga, Helen Rees, Neliëtte van Niekerk   +6 more
doaj   +1 more source

Refining the in vitro release test method for a dapivirine-releasing vaginal ring to match in vivo performance. [PDF]

Drug Deliv Transl Res, 2023
Previously reported in vitro release test methods for drug-releasing vaginal rings containing poorly water-soluble drugs have described use of water-alcohol systems or surfactant solutions in efforts to maintain sink conditions.
Murphy DJ, Lim D, Armstrong R, McCoy CF, Bashi YHD, Boyd P, Derrick T, Spence P, Devlin B, Malcolm RK.   +9 more
europepmc   +2 more sources

Randomized, placebo controlled phase I trial of the safety, pharmacokinetics, pharmacodynamics and acceptability of a 90 day tenofovir plus levonorgestrel vaginal ring used continuously or cyclically in women: The CONRAD 138 study

PLoS ONE, 2022
Multipurpose prevention technologies (MPTs), which prevent sexually transmitted infection(s) and unintended pregnancy, are highly desirable to women.
A. Thurman, V. Brache, L. Cochón, Louise A. Ouattara, N. Chandra, T. Jacot, Nazita Yousefieh, M. Clark, M. Peet, Homaira Hanif, J. Schwartz, Susan Ju, M. Marzinke, D. Erikson, U. Parikh, B. Herold, R. Fichorova, E. Tolley, G. Doncel   +18 more
semanticscholar   +1 more source

Acceptability of the Dapivirine Vaginal Ring for HIV-1 Prevention and Association with Adherence in a Phase III Trial

Aids and Behavior, 2021
We evaluated the acceptability of the 25 mg dapivirine vaginal ring (DVR) as an HIV prevention intervention and its influence on DVR adherence in the MTN-020/ASPIRE phase III trial.
Ashley J. Mayo, E. N. Browne, E. Montgomery, Kristine Torjesen, T. Palanee-Phillips, Nitesha Jeenarain, Linly Seyama, K. Woeber, Ishana Harkoo, K. Reddy, Tchangani Tembo, Prisca Mutero, T. Tauya, Miria Chitukuta, Brenda Gati Mirembe, L. Soto‐torres, Elizabeth R. Brown, Jared M. Baeten, A. van der Straten, Jared Thesla Elizabeth Lydia Katie Bonus Francis Linda-G Baeten Palanee-Phillips Brown Soto-Torres Schwartz, Jared M. Baeten, Elizabeth R. Brown, L. Soto‐torres, Katie D. Schwartz, B. Makanani, F. Martinson, L. Bekker, Vaneshree Govender, Samantha S. Siva, Zakir Gaffoor, Logashvari Naidoo, Arendevi Pather, Nitesha Jeenarain, G. Nair, F. Matovu, N. Mgodi, F. Mhlanga   +36 more
semanticscholar   +1 more source

“It’s already in your body and it’s preventing”: a qualitative study of African female adolescent’s acceptability and preferences for proxy HIV prevention methods in Cape Town, South Africa

BMC Public Health, 2023
Background Advances in biomedical HIV prevention will soon offer young women a choice of HIV prevention methods, including various pre-exposure prophylaxis (PrEP) modalities such as daily oral pills, dapivirine vaginal ring, and long-acting injectable ...
Lauren Fynn, Katherine Gill, Melissa Wallace, Millicent Atujuna, Menna Duyver, Penelope Ngcobo, Hans Spiegel, Alex Rinehart, Sybil Hosek, Linda-Gail Bekker   +9 more
doaj   +1 more source

Safety, Acceptability and Adherence of Dapivirine Vaginal Ring in a Microbicide Clinical Trial Conducted in Multiple Countries in Sub-Saharan Africa. [PDF]

PLoS ONE, 2016
BACKGROUND:This was the first microbicide trial conducted in Africa to evaluate an antiretroviral-containing vaginal ring as an HIV prevention technology for women.
Annalene Nel, Linda-Gail Bekker, Elizabeth Bukusi, Elizabeth Hellstrӧm, Philip Kotze, Cheryl Louw, Francis Martinson, Gileard Masenga, Elizabeth Montgomery, Nelisiwe Ndaba, Ariane van der Straten, Neliëtte van Niekerk, Cynthia Woodsong   +12 more
doaj   +1 more source