Results 11 to 20 of about 118,548,268 (167)

In vivo evaluation of the neurogenotoxic effects of exposure to validamycin A in neuroblasts of Drosophila melanogaster larval brain [PDF]

Journal of Applied Toxicology, Volume 44, Issue 3, Page 355-370, March 2024., 2023
Abstract Agriculture commonly utilizes crop protection products to tackle infestations from fungi, parasites, insects, and weeds. Validamycin A, an inhibitor of trehalase, possesses antibiotic and antifungal attributes. Epidemiological evidence has led to concerns regarding a potential link between pesticide usage and neurodegenerative diseases.
Fatma Turna Demir, Eşref Demir
wiley   +2 more sources

Validamycin Inhibits the Synthesis and Metabolism of Trehalose and Chitin in the Oriental Fruit Fly, Bactrocera dorsalis (Hendel). [PDF]

Insects, 2023
The oriental fruit fly, Bactrocera dorsalis (Hendel), is a notorious invasive pest that has raised concerns worldwide. Validamycin has been demonstrated to be a very strong inhibitor against trehalase in a variety of organisms.
Li Y, Xu Y, Wu S, Wang B, Li Y, Liu Y, Wang J.   +6 more
europepmc   +2 more sources

Validamycin Ingestion: A Rare Case of Poisoning With a Surprisingly Benign Outcome - Our Experience in a Resource-Limited Emergency Setting. [PDF]

Clin Case Rep
ABSTRACT Validamycin ingestion is a rare encounter in emergency settings. There is no specific antidote, with management being largely symptomatic. Overzealous treatment and referral to higher centers are not necessary, as consumption of even large doses of Validamycin is non‐toxic to humans; rather, addressing the intention behind ingestion is more ...
Luitel A, Dahal S, Yadav K, Budhathoki B, Chaudary C, Poudel R.   +5 more
europepmc   +2 more sources

Trehalase Inhibitor Validamycin May Have Additional Mechanisms of Toxicology against Rhizoctonia cerealis. [PDF]

J Fungi (Basel), 2023
Sharp eyespot is a crucial disease affecting cereal plants, such as bread wheat (Triticum aestivum) and barley (Hordeum vulgare), and is primarily caused by the pathogenic fungus Rhizoctonia cerealis.
Yang X, Shu Y, Cao S, Sun H, Zhang X, Zhang A, Li Y, Ma D, Chen H, Li W.   +9 more
europepmc   +2 more sources

Unlocking the Bioactive Potential of Streptomyces: A Multidisciplinary Approach to Strain Improvement. [PDF]

Microbiologyopen
This paper aims to address critical gaps in the literature by providing a comprehensive, integrative synthesis of recent advances in Streptomyces strain improvement, with a particular focus on optimizing secondary metabolite production through a multidisciplinary approach.
Goraya A, Fariq A, Fatima A, Abidi SHI, Marwat SA, Abdi G.   +5 more
europepmc   +2 more sources

Determination of the Fungicide Validamycin A by Capillary Zone Electrophoresis with Indirect UV Detection

, 2016
Validamycin A, a main component of the antibiotic validamycin complex, which is widely used to control sheath blight disease of rice plants, can be determined by capillary zone electrophoresis with indirect UV detection.
Jin He (341320), Jun Yao (9646), Zi-Niu Yu (22300), Li-Fang Ruan (2728924), Shou-Wen Chen (2728921), Li-Li Cao (2728927)   +5 more
core   +4 more sources

Hazard Assessment of the Effects of Acute and Chronic Exposure to Permethrin, Copper Hydroxide, Acephate, and Validamycin Nanopesticides on the Physiology of Drosophila: Novel Insights into the Cellular Internalization and Biological Effects. [PDF]

Int J Mol Sci, 2022
New insights into the interactions between nanopesticides and edible plants are required in order to elucidate their impacts on human health and agriculture. Nanopesticides include formulations consisting of organic/inorganic nanoparticles.
Demir E, Kansız S, Doğan M, Topel Ö, Akkoyunlu G, Kandur MY, Turna Demir F.   +6 more
europepmc   +2 more sources

Validamycin Inhibits the Reproductive Capacity of Spodoptera frugiperda (Lepidoptera: Noctuidae) by Suppressing the Activity of Trehalase. [PDF]

Insects
Spodoptera frugiperda (J. E. Smith, 1797), an omnivorous crop pest worldwide, reproduces prolifically. Validamycin, a competitive natural inhibitor of trehalase, is regarded as an effective and safe insecticide.
Zhong F, Wan S, Hu S, Ge Y, Han Y, Zhang X, Zhou M, Li Y, Tang B.   +8 more
europepmc   +2 more sources

Ralstonia solanacearum and Xanthomonas perforans as Causal Agents of Bacterial Disease of Tomato. [PDF]

Microbiologyopen
An extensive review of Xanthomonas perforans and Ralstonia solanacearum, two important tomato pathogens, with a focus on disease progression and new methods of management. ABSTRACT Tomatoes are produced worldwide, and in South Africa, they are cultivated in all provinces.
Modiba MP, Bell T, Glick B, Babalola OO.
europepmc   +2 more sources

Comparative genomic and metabolomic study of three Streptomyces sp. differing in biological activity

MicrobiologyOpen, Volume 12, Issue 6, December 2023., 2023
This work demonstrates that the analysis of the metabolomes and the genomes of phylogenetically closely related strains which show different phenotypes can lead in a straightforward way to elucidate the compounds responsible for the observed phenotypes.
Alisson Gillon, Ola Abdelrahman, Eliane Abou‐Mansour, Floriane L'Haridon, Laurent Falquet, Pierre‐Marie Allard, Laure Weisskopf   +6 more
wiley   +1 more source