Results 21 to 30 of about 118,548,268 (167)

The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective

The Journal of Physiology, Volume 601, Issue 20, Page 4491-4538, 15 October 2023., 2023
Abstract figure legend Acute and chronic stress exert wide‐ranging effects across the gut–brain axis. In the case of acute stress, the enteric nervous system may be activated and gut contractility modified. This is associated with altered serotonin metabolism in the gastrointestinal tract as well as activation of the innate immune system and ...
Sarah‐Jane Leigh, Friederike Uhlig, Lars Wilmes, Paula Sanchez‐Diaz, Cassandra E. Gheorghe, Michael S. Goodson, Nancy Kelley‐Loughnane, Niall P. Hyland, John F. Cryan, Gerard Clarke   +9 more
wiley   +1 more source

Analysis of validamycin as a potential antifungal compound against Candida albicans [PDF]

, 2013
Validamycin A has been successfully applied in the fight against phytopathogenic fungi. Here, the putative antifungal effect of this pseudooligosaccharide against the prevalent human pathogen Candida albicans was examined.
Martínez-Esparza Alvargonzález, María Concepción, Valentín, Eulogio, Martínez-Esparza, María, Guirao Abad, José P., Argüelles, Juan-Carlos, Argüelles, Juan Carlos, Sánchez-Fresneda, Ruth, Sánchez Fresneda, Ruth, Guirao-Abad, José P.   +8 more
core   +1 more source

Enhanced Antifungal Efficacy of Validamycin A Co-Administered with Bacillus velezensis TCS001 against Camellia anthracnose. [PDF]

Plants (Basel)
Anthracnose, a fungal disease harming fruit trees and crops, poses a threat to agriculture. Traditional chemical pesticides face issues like environmental pollution and resistance.
Chen Z, Cao H, Jin J, Li Z, Zhang S, Chen J.   +5 more
europepmc   +2 more sources

New Active Ingredients for Sustainable Modern Chemical Crop Protection in Agriculture. [PDF]

ChemSusChem
To ensure sustainability in crop protection, development of modern agrochemicals with improved selectivity, efficacy and environmental profile is essential. This ambitious goal can be achieved, for example, by considering halogen‐containing motifs or sterogenic centers in an active ingredient, having a significant influence on its physico‐chemical ...
Jeschke P.
europepmc   +2 more sources

Modeling, virtual screening, and enzymatic docking of trehalose 6-phosphate phosphatase and evaluation of the insecticidal effect of phthalimide, N-(p-tolylsulfonyl) on Aedes aegypti (Diptera: Culicidae). [PDF]

Pest Manag Sci
Schematic diagram of the experimental procedures used to perform the bioinformatic steps and insecticidal assays using trehalose 6‐phosphate phosphatase of Aedes aegypti and the molecule phthalimide, N‐(p‐tolylsulfonyl). Abstract BACKGROUND Aedes aegypti Linnaeus is a medically important vector because of its role in transmitting several arboviruses ...
Lima RJV, Zanchi FB, Guimarães RMS, E Silva AA.   +3 more
europepmc   +2 more sources

Catalytic Analysis of the Validamycin Glycosyltransferase (ValG) and Enzymatic Production of 4′′-epi-Validamycin A

, 2016
ValG is a glycosyltransferase (GT) that is responsible for the glucosylation of validoxylamine A to validamycin A. To explore the potential utilization of ValG as a tool for the production of validamycin analogues, a number of nucleotidyldiphosphate ...
Linquan Bai (331158), Taifo Mahmud (307800), Kazuyuki Minagawa (2428333), Zixin Deng (31222), Hui Xu (9203)   +4 more
core   +1 more source

Structural and functional analysis of validoxylamine A 7'-phosphate synthase ValL involved in validamycin A biosynthesis. [PDF]

, 2012
Validamycin A (Val-A) is an effective antifungal agent widely used in Asian countries as crop protectant. Validoxylamine A, the core structure and intermediate of Val-A, consists of two C(7)-cyclitol units connected by a rare C-N bond.
Linquan Bai, Zhang Huaidong, Lei Li, Houjin Zhang, Zhou Xiang, Bai Linquan, Ji Xiaofeng, Li Lei, Xiang Zhou, Huang Lin, Zheng Lina, Xiaofeng Ji, Huaidong Zhang, Lina Zheng, Lin Huang, Zhang Houjin   +15 more
core   +1 more source

Assessment of the Novel Anti-Seizure Potential of Validamycin A Using Zebrafish Epilepsy Model. [PDF]

Molecules
Epilepsy is a prevalent neurological disorder characterized by recurrent seizures. Validamycin A (VA) is an antibiotic fungicide that inhibits trehalase activity and is widely used for crop protection in agriculture.
Lee E, Banik A, Lee KB, Sim SM, Kil AH, Hwang BJ, Kee Y.   +6 more
europepmc   +2 more sources

Salicylic acid: a key natural foundation for next‐generation plant defense stimulators

Pest Management Science, Volume 82, Issue 3, Page 2165-2176, March 2026.
Salicylic acid is emerging as a key natural molecule in sustainable crop protection, supporting diverse strategies to stimulate and sustain plant immunity for a greener agricultural future. Abstract The field of crop protection is undergoing a major transition.
Ruth Oussou, Sylvain La Camera, Cécile Marivingt‐Mounir, Jean‐François Chollet   +3 more
wiley   +1 more source

Extracellular Particles Derived From Mesenchymal Stromal Cells Reduce Pseudomonas aeruginosa Lung Infection and Inflammation in Mice

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT The World Health Organization and the U.S. Centre for Disease Control and Prevention have reported that antibiotic‐resistant infections with Pseudomonas aeruginosa present a significant health risk worldwide. In the genetic disease Cystic Fibrosis (CF), chronic antibiotic‐resistant Pseudomonas lung infections and persistent inflammation remain
Sharanya Sarkar, Roxanna Barnaby, Zachary Faber, Lily Taub, Carolyn Roche, Lily A. Charpentier, Thomas H. Hampton, Brad Vietje, Douglas J. Taatjes, Byoung‐Kyu Cho, Young Ah Goo, Matthew J. Wargo, Daniel J. Weiss, Tracey L. Bonfield, Thomas J. Kelley, Bruce A. Stanton   +15 more
wiley   +1 more source