Results 91 to 100 of about 6,428,897 (326)

Who Validates the Validators?

, 2022
Given a fip:Metadata-schema and a validator for it, such as a sh:Validator or a JSON Schema, how do you determine that the validator is…valid? That it speaks the desired fip:Knowledge-representation-language, that it knows all the terms in a desired fip:Structured-vocabulary and checks their usage against a desired fip:Semantic-model?
openaire   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Uniform: The Form Validation Language [PDF]

, 2016
Digital forms are becoming increasingly more prevalent but the ease of creation is not. Web Forms are difficult to produce and validate. This design project seeks to simplify this process.
Novak, Sawyer, Palmquist, Reid, Parker, Douglas   +2 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Integrative network analysis suggests prioritised drugs for atopic dermatitis

Journal of Translational Medicine
Background Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease whose pathophysiology involves the interplay between genetic and environmental factors, ultimately leading to dysfunction of the epidermis.
Antonio Federico, Lena Möbus, Zeyad Al-Abdulraheem, Alisa Pavel, Vittorio Fortino, Giusy del Giudice, Harri Alenius, Nanna Fyhrquist, Dario Greco   +8 more
doaj   +1 more source

Effects of turbulent heat diffusion and viscosity on the simulation of turbulent mixing in autonomous PWR subchannel analysis software

International Journal of Advanced Nuclear Reactor Design and Technology
In this paper the turbulent mixing models of several domestic autonomous PWR subchannel software under review by the national nuclear safety administration were evaluated and studied.
Bin Jia, Jie-Ru An, Guang-Yu Zhu, Xin-Li Gao, Xue-Dong Qiao, Xiao-Qiang He   +5 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Optimal Data Split Methodology for Model Validation [PDF]

, 2011
The decision to incorporate cross-validation into validation processes of mathematical models raises an immediate question - how should one partition the data into calibration and validation sets?
Bryant, Corey, Miki, Kenji, Morrison, Rebecca, Prudhomme, Serge, Terejanu, Gabriel   +4 more
core  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Identification of damage based on frequency response function (FRF) data

MATEC Web of Conferences, 2017
Mechanical joints, particularly fasteners such as bolted joints have a complex non-linear behaviour. The non-linearity might emerge from the material, geometry or by the contacts in the joints.
Sulaiman M. S. A., Yunus M. A., Bahari A. R., Abdul Rani M. N.   +3 more
doaj   +1 more source