Results 41 to 50 of about 6,125,000 (281)

An information architecture for validating courseware [PDF]

, 2007
Courseware validation should locate Learning Objects inconsistent with the courseware instructional design being used. In order for validation to take place it is necessary to identify the implicit and explicit information needed for validation.
Melia, Mark, Pahl, Claus
core  

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Consistent Calibration of VIRR Reflective Solar Channels Onboard FY-3A, FY-3B, and FY-3C Using a Multisite Calibration Method

Remote Sensing, 2018
The FengYun-3 (FY-3) Visible Infrared Radiometer (VIRR), along with its predecessor, the Multispectral Visible Infrared Scanning Radiometer (MVISR), onboard the FY-1C and FY-1D, has collected continuous daily global observations for 18 years.
Ling Wang, Xiuqing Hu, Lin Chen, Lingli He   +3 more
doaj   +1 more source

Multiplicative local linear hazard estimation and best one-sided cross-validation [PDF]

, 2017
This paper develops detailed mathematical statistical theory of a new class of cross-validation techniques of local linear kernel hazards and their multiplicative bias corrections.
Gámiz Pérez, M. L., Martinez-Miranda, M. D., Nielsen, J. P.   +2 more
core   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

CRISPR-mediated promoter editing of a cis-regulatory element of OsNAS2 increases Zn uptake/translocation and plant yield in rice

Frontiers in Genome Editing
Developing nutritious rice with a higher yield is one approach to alleviating the problem of micronutrient deficiency in developing countries, especially human malnutrition involving zinc and iron (Fe) deficiency, and achieving better adoption.
Yvonne Ludwig, Conrado Dueñas, Erwin Arcillas, Reena Jesusa Macalalad-Cabral, Ajay Kohli, Russell Reinke, Inez H. Slamet-Loedin   +6 more
doaj   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Validation of suply chain integration scales and the effect that size, level of vertical integration, industry and country have on their value [PDF]

, 2012
Academic literature would appear to indicate that supply chain integration is a major factor in explaining the performance of companies. The results are nevertheless inconclusive.
Alfalla Luque, Rafaela, Marín García, Juan Antonio, Medina López, Carmen   +2 more
core  

Validation of Voting Committees [PDF]

, 1997
This article contains a method to bound the test errors of voting committees with members chosen from a pool of trained classifiers. There are so many prospective committees that validating them directly does not achieve useful error bounds.
Bax, Eric
core   +4 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source