Results 71 to 80 of about 9,445,211 (322)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
BioTechniques, 2010 Antibodies are among the most frequently used tools in basic science research and in clinical assays, but there are no universally accepted guidelines or standardized methods for determining the validity of these reagents. Furthermore, for commercially available antibodies, it is clear that what is on the label does not necessarily correspond to what ...
Jennifer Bordeaux +7 more
openaire +3 more sources
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Endothelial sensitivity to pro-fibrotic signals links systemic exposure to pulmonary fibrosis
Cell Death and DiseasePulmonary fibrosis (PF) is a life-threatening condition characterised by excessive extracellular matrix deposition and tissue scarring. While much of PF research has focused on alveolar epithelial cells and fibroblasts, endothelial cells have emerged as ...
Lena Möbus +7 more
doaj +1 more source
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids
Nucleic Acids Res., 2007 MolProbity is a general-purpose web server offering quality validation for 3D structures of proteins, nucleic acids and complexes. It provides detailed all-atom contact analysis of any steric problems within the molecules as well as updated dihedral ...
Ian W. Davis +11 more
semanticscholar +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
An Adaptive Dark-Target Algorithm for Retrieving Land AOD Applied to FY-4B/AGRI Data
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingThe Fengyun 4B (FY-4B) as an operational satellite was launched on 3 June 2021. The advanced geostationary radiation imager (AGRI) aboard on the FY-4B has ability to monitor aerosols information.
Yidan Si +9 more
doaj +1 more source
Remote Sensing, 2013 Based on simulated reflectance, deep convective clouds (DCC) can be used as an invariant target to monitor the radiometric response degradation of the FY-3A/MERSI (Medium Resolution Spectral Imager) reflective solar bands (RSBs).
Lin Chen, Xiuqing Hu, Na Xu, Peng Zhang
doaj +1 more source
Fast Cross-Validation via Sequential Testing [PDF]
, 2015 With the increasing size of today's data sets, finding the right parameter configuration in model selection via cross-validation can be an extremely time-consuming task.
Braun, Mikio +2 more
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