Results 81 to 90 of about 9,445,211 (322)

Validation of Geant4-based Radioactive Decay Simulation

, 2013
Radioactive decays are of concern in a wide variety of applications using Monte-Carlo simulations. In order to properly estimate the quality of such simulations, knowledge of the accuracy of the decay simulation is required.
Batič, Matej, Bell, Zane W., Hauf, Steffen, Hoffmann, Dieter H. H., Kuster, Markus, Lang, Philipp M., Neff, Stephan, Pia, Maria Grazia, Weidenspointner, Georg, Zoglauer, Andreas   +9 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Behavioural study of PEMFC during start-up/shutdown cycling for aeronautic applications

Materials for Renewable and Sustainable Energy, 2019
The deployment of proton exchange membrane fuel cell (PEMFC) for aeronautic applications is a value-added energy supply alternative that not only generates useful byproducts (oxygen-depleted air, water and heat) but addresses sensitive issues such as ...
Noluntu Dyantyi, Adrian Parsons, Piotr Bujlo, Sivakumar Pasupathi   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Asprosin Aggravates Tubular Epithelial Cell Injury and Phenotypic Transformation via Mitochondrial Dynamics Disorder Mediated by Excessive Drp1 SUMOylation in Diabetic Nephropathy Mice

Advanced Science
Epidemiological studies show that some diabetic patients develop end‐stage renal dysfunction without significant proteinuria or glomerulopathy, underscoring the role of renal tubular epithelial cell (TEC) impairment in diabetic kidney disease (DKD ...
Qianqian Huang, Xiaowei Xiong, Sheng Chen, Yuan Wang, Li Wang, Wentao Liu, Chen Liu, Guohua Zeng, Qiren Huang   +8 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Synthesizing Short-Circuiting Validation of Data Structure Invariants

, 2015
This paper presents incremental verification-validation, a novel approach for checking rich data structure invariants expressed as separation logic assertions. Incremental verification-validation combines static verification of separation properties with
Chang, Bor-Yuh Evan, Coughlin, Devin, Rival, Xavier, Tsai, Yi-Fan   +3 more
core   +1 more source

Model validation of spatiotemporal systems using correlation function tests [PDF]

, 2006
Model validation is an important and essential final step in system identification. Although model validation for nonlinear temporal systems has been extensively studied, model validation for spatiotemporal systems is still an open question.
Billings, S.A., Pan, Y.
core  

On Regularization Parameter Estimation under Covariate Shift

, 2016
This paper identifies a problem with the usual procedure for L2-regularization parameter estimation in a domain adaptation setting. In such a setting, there are differences between the distributions generating the training data (source domain) and the ...
Kouw, Wouter M., Loog, Marco
core   +1 more source