Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy [PDF]
Cells, 2019 Acute myeloid leukemia (AML) is an aggressive malignancy, and many elderly/unfit patients cannot receive intensive and potentially curative therapy. These patients receive low-toxicity disease-stabilizing treatment.
Bruserud, Øystein +4 more
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Improving basic and translational science by accounting for litter-to-litter variation in animal models [PDF]
BMC Neuroscience 2013, 14:37, 2013 Background: Animals from the same litter are often more alike compared with animals from different litters. This litter-to-litter variation, or "litter effects", can influence the results in addition to the experimental factors of interest.
Essioux, Laurent, Lazic, Stanley E.
core +3 more sources
Nomogram for the prediction of valproic acid induced platelet decline: a nested case–control study [PDF]
Scientific ReportsPlatelet decline is a frequent side effect of valproic acid, a medication commonly prescribed to prevent seizures in neurosurgical patients. However, the risk factors for valproic acid-associated platelet decline remain poorly understood, and it remains ...
Gang Cheng +6 more
doaj +2 more sources
Valproic Acid-induced Agranulocytosis
International Journal of Gerontology, 2009 SummaryValproic acid is considered to be the most well-tolerated antiepileptic drug. However, few cases of neutropenia or leukopenia caused by valproic acid have been reported. We present a patient who took valproic acid to treat a complication of brain surgery and in whom severe agranulocytosis occurred after 2.5 months.
Hsiang-Kuang Tseng +4 more
openaire +4 more sources
High Blood Ammonia Levels Associated with Long-term Valproic Acids Therapy in Epileptic Children [PDF]
MCBS (Molecular and Cellular Biomedical Sciences), 2020 Background: Valproic acid is an effective drug for controlling seizure in children with epilepsy and it is usually used for treatment as long as two years or more.
Sidiartha, I Gusti Lanang +3 more
core +4 more sources
Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines [PDF]
Cancer Cell International, 2006 BACKGROUND: Among the epigenetic alterations occurring in cancer, DNA hypermethylation and histone hypoacetylation are the focus of intense research because their pharmacological inhibition has shown to produce antineoplastic activity in a variety of ...
Cabrera, Gustavo +11 more
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Retrospective Analysis of 2 992 Times of Therapeutic Drug Monitoring of Valproic Acid from 2019 to 2021 [PDF]
Zhongguo quanke yixue, 2023 Background Valproic acid, as a mood stabilizer, has been extensively used for the treatment of bipolar disorder and other psychiatric conditions. Although therapeutic drug monitoring (TDM) of valproic acid has been carried out at home and abroad for many
DING Jing, MENG Zhuocheng, ZHANG Yan, CUI Xiaohua, LIU Jiarui, HE Jiao, ZHANG Yang, LI Yajuan, YANG Liu
doaj +1 more source
Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats [PDF]
, 2023 Valproic acid, one of the most used drugs for epilepsy patients, has some known side effects. Chard extract has many pharmacological activities. The study aims to evaluate whether valproic acid might interfere with oxidative metabolism in gastric tissue ...
Alev Tüzüner, Burçin +7 more
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Use of valproic acid in long stay units of psychiatry [PDF]
Farmacia Hospitalaria, 2015 Objective: Valproic acid is often used in psychiatry to treat schizophrenia and other conditions outside of indication (“off-label”). However, its effectiveness has not been sufficiently demonstrated and its use is not exempt of adverse effects.
Mª Teresa Martínez-Lazcano +5 more
doaj +1 more source